Veterinary Quarterly,
Journal Year:
2024,
Volume and Issue:
44(1), P. 1 - 23
Published: July 7, 2024
Mastitis
is
an
inflammatory
condition
that
affects
dairy
cow's
mammary
glands.
Traditional
treatment
approaches
with
antibiotics
are
increasingly
leading
to
challenging
scenarios
such
as
antimicrobial
resistance.
In
order
mitigate
the
unwanted
side
effects
of
antibiotics,
alternative
strategies
those
harness
host
immune
system
response,
also
known
immunotherapy,
have
been
implemented.
Immunotherapy
treat
bovine
mastitis
aims
enhance
response
against
pathogens
by
promoting
pathogen
clearance,
and
facilitating
tissue
repair.
Various
studies
demonstrated
potential
immunotherapy
for
reducing
incidence,
duration
severity
mastitis.
Nevertheless,
majority
reported
therapies
lacking
in
specificity
hampering
their
broad
application
Meanwhile,
advancements
hold
great
promise
industry,
provide
effective
sustainable
alternatives
traditional
antibiotic-based
approaches.
This
review
synthesizes
strategies,
current
understanding
future
perspectives.
The
perspectives
should
focus
on
development
precision
immunotherapies
tailored
address
individual
pathogens/group
pathogens,
combination
resistance,
integration
nano-
omics
technologies.
By
addressing
research
gaps,
field
can
make
significant
strides
control,
prevention
mastitis,
ultimately
benefiting
both
animal
human
health/welfare,
environment
health.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Nov. 26, 2024
Epigenetics
governs
a
chromatin
state
regulatory
system
through
five
key
mechanisms:
DNA
modification,
histone
RNA
remodeling,
and
non-coding
regulation.
These
mechanisms
their
associated
enzymes
convey
genetic
information
independently
of
base
sequences,
playing
essential
roles
in
organismal
development
homeostasis.
Conversely,
disruptions
epigenetic
landscapes
critically
influence
the
pathogenesis
various
human
diseases.
This
understanding
has
laid
robust
theoretical
groundwork
for
developing
drugs
that
target
epigenetics-modifying
pathological
conditions.
Over
past
two
decades,
growing
array
small
molecule
targeting
such
as
methyltransferase,
deacetylase,
isocitrate
dehydrogenase,
enhancer
zeste
homolog
2,
have
been
thoroughly
investigated
implemented
therapeutic
options,
particularly
oncology.
Additionally,
numerous
epigenetics-targeted
are
undergoing
clinical
trials,
offering
promising
prospects
benefits.
review
delineates
epigenetics
physiological
contexts
underscores
pioneering
studies
on
discovery
implementation
drugs.
include
inhibitors,
agonists,
degraders,
multitarget
agents,
aiming
to
identify
practical
challenges
avenues
future
research.
Ultimately,
this
aims
deepen
epigenetics-oriented
strategies
further
application
settings.
Molecular Cancer,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Aug. 30, 2024
Drug
resistance
in
cancer
cells
significantly
diminishes
treatment
efficacy,
leading
to
recurrence
and
metastasis.
A
critical
factor
contributing
this
is
the
epigenetic
alteration
of
gene
expression
via
RNA
modifications,
such
as
N6-methyladenosine
(m6A),
N1-methyladenosine
(m1A),
5-methylcytosine
(m5C),
7-methylguanosine
(m7G),
pseudouridine
(Ψ),
adenosine-to-inosine
(A-to-I)
editing.
These
modifications
are
pivotal
regulating
splicing,
translation,
transport,
degradation,
stability.
Governed
by
"writers,"
"readers,"
"erasers,"
impact
numerous
biological
processes
progression,
including
cell
proliferation,
stemness,
autophagy,
invasion,
apoptosis.
Aberrant
can
lead
drug
adverse
outcomes
various
cancers.
Thus,
targeting
modification
regulators
offers
a
promising
strategy
for
overcoming
enhancing
efficacy.
This
review
consolidates
recent
research
on
role
prevalent
resistance,
with
focus
m6A,
m1A,
m5C,
m7G,
Ψ,
A-to-I
Additionally,
it
examines
regulatory
mechanisms
linked
underscores
existing
limitations
field.
The EMBO Journal,
Journal Year:
2025,
Volume and Issue:
44(3), P. 613 - 638
Published: Jan. 9, 2025
Dysregulation
of
RNA
processing
has
in
recent
years
emerged
as
a
significant
contributor
to
neurodegeneration.
The
diverse
mechanisms
and
molecular
functions
underlying
underscore
the
essential
role
regulation
maintaining
neuronal
health
function.
molecules
are
bound
by
RNA-binding
proteins
(RBPs),
interactions
between
RNAs
RBPs
commonly
affected
In
this
review,
we
highlight
progress
understanding
dysregulated
RNA-processing
pathways
causes
RBP
dysfunction
across
various
neurodegenerative
diseases.
We
discuss
both
established
emerging
RNA-mediated
neuropathogenesis
rapidly
evolving
field.
Furthermore,
explore
development
potential
RNA-targeting
therapeutic
approaches
for
treatment
Journal of Pharmacy & Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
27
Published: April 19, 2024
Unhealthy
sources
of
fats,
ultra-processed
foods
with
added
sugars,
and
a
sedentary
lifestyle
make
humans
more
susceptible
to
developing
overweight
obesity.
While
lipids
constitute
an
integral
component
the
organism,
excessive
abnormal
lipid
accumulation
that
exceeds
storage
capacity
droplets
disrupts
intracellular
composition
fatty
acids
results
in
release
deleterious
species,
thereby
giving
rise
pathological
state
termed
lipotoxicity.
This
condition
induces
endoplasmic
reticulum
stress,
mitochondrial
dysfunction,
inflammatory
responses,
cell
death.
Recent
advances
omics
technologies
analytical
methodologies
clinical
research
have
provided
novel
insights
into
mechanisms
lipotoxicity,
including
gut
dysbiosis,
epigenetic
epitranscriptomic
modifications,
dysfunction
droplets,
post-translational
altered
membrane
composition.
In
this
review,
we
discuss
recent
knowledge
on
underlying
development
lipotoxicity
lipotoxic
cardiometabolic
disease
obesity,
particular
focus
diabetic
cardiomyopathy.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: April 9, 2024
Abstract
Innovative
approaches
to
controlled
nucleobase-modified
RNA
synthesis
are
urgently
needed
support
biology
exploration
and
synthesize
potential
therapeutics.
Here
we
present
a
strategy
for
enzymatic
construction
of
based
on
primer-dependent
engineered
thermophilic
DNA
polymerases
–
SFM4-3
TGK.
We
demonstrate
introduction
one
or
several
different
base-modified
nucleotides
in
strand
including
hypermodified
containing
all
four
modified
bearing
substituents,
as
well
primer
segment
removal.
also
show
facile
site-specific
segmented
fluorophores
other
functional
groups
at
defined
positions
variety
molecules,
structured
long
mRNA.
Intriguing
translation
efficacy
single-site
mRNAs
underscores
the
necessity
study
isolated
modifications
placed
designer
disentangle
their
biological
effects
enable
development
improved
mRNA
Our
toolbox
paves
way
more
precise
dissecting
structures
functions,
diverse
types
base-functionalized
therapeutic
applications
diagnostics.
Experimental & Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
56(6), P. 1293 - 1321
Published: June 14, 2024
Abstract
The
exponential
growth
of
big
data
in
RNA
biology
(RB)
has
led
to
the
development
deep
learning
(DL)
models
that
have
driven
crucial
discoveries.
As
constantly
evidenced
by
DL
studies
other
fields,
successful
implementation
RB
depends
heavily
on
effective
utilization
large-scale
datasets
from
public
databases.
In
achieving
this
goal,
encoding
methods,
algorithms,
and
techniques
align
well
with
biological
domain
knowledge
played
pivotal
roles.
review,
we
provide
guiding
principles
for
applying
these
concepts
various
problems
demonstrating
examples
associated
methodologies.
We
also
discuss
remaining
challenges
developing
suggest
strategies
overcome
challenges.
Overall,
review
aims
illuminate
compelling
potential
ways
apply
powerful
technology
investigate
intriguing
more
effectively.
Cell chemical biology,
Journal Year:
2024,
Volume and Issue:
31(6), P. 1101 - 1117
Published: June 1, 2024
RNA-targeting
small
molecules
(rSMs)
have
become
an
attractive
modality
to
tackle
traditionally
undruggable
proteins
and
expand
the
druggable
space.
Among
many
innovative
concepts,
chimeras
(RNATACs)
represent
a
new
class
of
multispecific,
induced
proximity
that
act
by
chemically
bringing
RNA
targets
into
with
endogenous
effector,
such
as
ribonuclease
(RNase).
Depending
on
RNATACs
can
alter
stability,
localization,
translation,
or
splicing
target
RNA.
Although
still
in
its
infancy,
this
has
potential
for
broad
applications
future
treat
diseases
high
unmet
need.
In
review,
we
discuss
advantages
RNATACs,
recent
progress
field,
challenges
cutting-edge
technology.
