Veterinary Quarterly,
Journal Year:
2024,
Volume and Issue:
44(1), P. 1 - 23
Published: July 7, 2024
Mastitis
is
an
inflammatory
condition
that
affects
dairy
cow's
mammary
glands.
Traditional
treatment
approaches
with
antibiotics
are
increasingly
leading
to
challenging
scenarios
such
as
antimicrobial
resistance.
In
order
mitigate
the
unwanted
side
effects
of
antibiotics,
alternative
strategies
those
harness
host
immune
system
response,
also
known
immunotherapy,
have
been
implemented.
Immunotherapy
treat
bovine
mastitis
aims
enhance
response
against
pathogens
by
promoting
pathogen
clearance,
and
facilitating
tissue
repair.
Various
studies
demonstrated
potential
immunotherapy
for
reducing
incidence,
duration
severity
mastitis.
Nevertheless,
majority
reported
therapies
lacking
in
specificity
hampering
their
broad
application
Meanwhile,
advancements
hold
great
promise
industry,
provide
effective
sustainable
alternatives
traditional
antibiotic-based
approaches.
This
review
synthesizes
strategies,
current
understanding
future
perspectives.
The
perspectives
should
focus
on
development
precision
immunotherapies
tailored
address
individual
pathogens/group
pathogens,
combination
resistance,
integration
nano-
omics
technologies.
By
addressing
research
gaps,
field
can
make
significant
strides
control,
prevention
mastitis,
ultimately
benefiting
both
animal
human
health/welfare,
environment
health.
Nucleic Acids Research,
Journal Year:
2024,
Volume and Issue:
52(15), P. 9230 - 9246
Published: July 2, 2024
Abstract
In
higher
eukaryotes,
tRNA
methyltransferase
10A
(TRMT10A)
is
responsible
for
N1-methylguanosine
modification
at
position
nine
of
various
cytoplasmic
tRNAs.
Pathogenic
mutations
in
TRMT10A
cause
intellectual
disability,
microcephaly,
diabetes,
and
short
stature
humans,
generate
cytotoxic
fragments
cultured
cells;
however,
it
not
clear
how
supports
codon
translation
or
brain
functions.
Here,
we
generated
Trmt10a
null
mice
showed
that
tRNAGln(CUG)
initiator
methionine
levels
were
universally
decreased
tissues;
the
same
was
true
a
human
cell
line
lacking
TRMT10A.
Ribosome
profiling
mouse
revealed
dysfunction
causes
ribosome
slowdown
Gln(CAG)
increases
Atf4
due
to
frequency
leaky
scanning
its
upstream
open
reading
frames.
Broadly
speaking,
subset
mRNAs,
especially
those
neuronal
structures,
perturbed
mutant
brain.
Despite
showing
discernable
defects
pancreas,
liver,
kidney,
lower
body
weight
smaller
hippocampal
postsynaptic
densities,
which
associated
with
defective
synaptic
plasticity
memory.
Taken
together,
our
study
provides
mechanistic
insight
into
roles
brain,
exemplifies
importance
universal
during
specific
codons.
European Heart Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 25, 2024
Vascular
smooth
muscle
cell
(VSMC)
phenotype
switching
is
a
pathological
hallmark
in
various
cardiovascular
diseases.
N4-acetylcytidine
(ac4C)
catalyzed
by
N-acetyltransferase
10
(NAT10)
well
conserved
the
enzymatic
modification
of
ribonucleic
acid
(RNA).
NAT10-mediated
ac4C
acetylation
involved
physiological
and
processes,
including
cardiac
remodelling.
However,
biological
functions
underlying
regulatory
mechanisms
mRNA
modifications
vascular
diseases
remain
elusive.
Veterinary Quarterly,
Journal Year:
2024,
Volume and Issue:
44(1), P. 1 - 23
Published: July 7, 2024
Mastitis
is
an
inflammatory
condition
that
affects
dairy
cow's
mammary
glands.
Traditional
treatment
approaches
with
antibiotics
are
increasingly
leading
to
challenging
scenarios
such
as
antimicrobial
resistance.
In
order
mitigate
the
unwanted
side
effects
of
antibiotics,
alternative
strategies
those
harness
host
immune
system
response,
also
known
immunotherapy,
have
been
implemented.
Immunotherapy
treat
bovine
mastitis
aims
enhance
response
against
pathogens
by
promoting
pathogen
clearance,
and
facilitating
tissue
repair.
Various
studies
demonstrated
potential
immunotherapy
for
reducing
incidence,
duration
severity
mastitis.
Nevertheless,
majority
reported
therapies
lacking
in
specificity
hampering
their
broad
application
Meanwhile,
advancements
hold
great
promise
industry,
provide
effective
sustainable
alternatives
traditional
antibiotic-based
approaches.
This
review
synthesizes
strategies,
current
understanding
future
perspectives.
The
perspectives
should
focus
on
development
precision
immunotherapies
tailored
address
individual
pathogens/group
pathogens,
combination
resistance,
integration
nano-
omics
technologies.
By
addressing
research
gaps,
field
can
make
significant
strides
control,
prevention
mastitis,
ultimately
benefiting
both
animal
human
health/welfare,
environment
health.
