Cell-Type-Specific Transposable Element Demethylation and TAD Remodeling in the Aging Mouse Brain

Published: Jan. 1, 2025

Language: Английский

Retrotransposon Protein L1 ORF1p Expression in Aging Central Nervous System

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4368 - 4368

Published: May 4, 2025

The long-interspersed elements (LINE-1; L1) represent the main active family of retrotransposons in human organism, comprising approximately 17% its content. L1 sequence codifies for two proteins involved retrotransposition: ORF1p, an RNA binding protein, and ORF2p, endowed with endonuclease reverse transcriptase activity. vast majority copies are inactive, only a small percentage retaining their retrotransposition capacity, posing threat to organism due mutagenic potential. To mitigate such risks, mammals have evolved intricate regulatory mechanisms, including heterochromatin formation degradation pathways. Age-related diminution these pathways may be particularly important within Central Nervous System (CNS), where cellular regeneration is limited, genomic integrity critical lifelong function. Here, we describe age-associated upregulation ORF1p mouse brain, indicating potential role activity aging. We further demonstrate presence across diverse CNS cell types, neurons, oligodendrocytes microglia. Notably, observe correlation between microglial activation, hallmark neuroinflammation, during This study advances our understanding dynamics underscores significance age-related neurological changes.

Language: Английский

Epitranscriptome–epigenome interactions in development and disease mechanisms

Trends in Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский