The immunomodulatory mechanisms for acupuncture practice DOI Creative Commons
Meng Wang, Weili Liu,

Jiayi Ge

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 6, 2023

The system physiology approaches that emerge in western countries recent years echo the holistic view of ancient Traditional Chinese Medicine (TCM) practices deal with root, rather than only symptoms diseases. Particularly, TCM practices, including acupuncture, emphasize mobilization self-healing mechanisms to bring back body homeostasis. Acupuncture has been practiced for over two thousand modulate via stimulation at specific regions (acupoints). With development various research on acupuncture therapy, its regulatory effect immune gradually recognized, especially immunological diseases, infectious and allergic In this study, we reviewed immunomodulatory mechanism systematically integrates existing respectively elucidate modulatory innate system, adaptive well-known neuroanatomical mechanisms, intact somatosensory-autonomic reflex pathway. advances made systems studies, now have a great opportunity gain insight into how modulates immunity, subsequently improves efficacy.

Language: Английский

NK cells for cancer immunotherapy DOI
Noriko Shimasaki, Amit Jain, Dario Campana

et al.

Nature Reviews Drug Discovery, Journal Year: 2020, Volume and Issue: 19(3), P. 200 - 218

Published: Jan. 6, 2020

Language: Английский

Citations

973
The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies DOI
Tobias Bald, Matthew F. Krummel, Mark J. Smyth

et al.

Nature Immunology, Journal Year: 2020, Volume and Issue: 21(8), P. 835 - 847

Published: July 20, 2020

Language: Английский

Citations

375
NK Cell Metabolism and Tumor Microenvironment DOI Creative Commons
Iñigo Terrén, Ane Orrantia, Joana Vitallé

et al.

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: Sept. 24, 2019

Natural Killer (NK) cells are characterized by their potential to kill tumor different means without previous sensitization and therefore, they have become a valuable tool in cancer immunotherapy. However, efficacy against solid tumors is still poor further studies required improve it. One of the major restrictions for NK cell activity immunosuppressive microenvironment (TME). There, other immune create appropriate conditions proliferation while, among others, preventing activation. Furthermore, metabolism impaired TME, presumably due nutrient oxygen deprivation, higher concentration tumor-derived metabolic end products, such as lactate. This restriction limits effector functions, it could represent target focus on cell-based therapies tumors. In this review, we discuss effect TME into its influence functions.

Language: Английский

Citations

371
Influence of the Tumor Microenvironment on NK Cell Function in Solid Tumors DOI Creative Commons
Ombretta Melaiu, Valeria Lucarini, Loredana Cifaldi

et al.

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 10

Published: Jan. 20, 2020

Natural killer (NK) cells are a population of innate lymphoid playing pivotal role in host immune responses against infection and tumor growth. These have powerful cytotoxic activity orchestrated by an intricate network inhibitory activating signals. The importance NK controlling growth mediating robust anti-metastatic effect has been demonstrated different experimental mouse cancer models. Consistently, high density tumor-infiltrating linked with good prognosis multiple human solid tumors. However, there also tumors that appear to be refractory cell-mediated killing for the presence immunosuppressive microenvironment affecting cell function. Immunotherapeutic strategies aimed at restoring increasing tumors, including adoptive transfer CAR-NK cells, currently employed preclinical clinical studies. In this review, we outline recent advances supporting direct expansion their prognostic value cancers. We summarize mechanisms adopted affect function, finally evaluate current augment antitumor function treatment

Language: Английский

Citations

339
Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity DOI Creative Commons
Zhu Huang, Robert Blum,

Davide Bernareggi

et al.

Cell stem cell, Journal Year: 2020, Volume and Issue: 27(2), P. 224 - 237.e6

Published: June 11, 2020

Language: Английский

Citations

246
Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance DOI
Xiaohu Zheng, Yeben Qian, Binqing Fu

et al.

Nature Immunology, Journal Year: 2019, Volume and Issue: 20(12), P. 1656 - 1667

Published: Oct. 21, 2019

Language: Английский

Citations

216
Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19 DOI Creative Commons
Can Liu, Andrew J. Martins, William Lau

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(7), P. 1836 - 1857.e22

Published: Feb. 10, 2021

Language: Английский

Citations

208
Immunometabolism in the Brain: How Metabolism Shapes Microglial Function DOI
Louis‐Philippe Bernier, Elisa M. York, Brian A. MacVicar

et al.

Trends in Neurosciences, Journal Year: 2020, Volume and Issue: 43(11), P. 854 - 869

Published: Sept. 18, 2020

Language: Английский

Citations

181
The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity DOI Creative Commons
Yuan Xiong, Bobin Mi, Ze Lin

et al.

Military Medical Research, Journal Year: 2022, Volume and Issue: 9(1)

Published: Nov. 19, 2022

Abstract Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting variety of cell types, whose activity interplay must be precisely mediated for effective healing post-injury. Although extensive strides have been made in the understanding immune microenvironment processes governing bone, regeneration, clinical translation these mechanisms remains challenge. Regulation increasingly becoming favorable target regeneration; therefore, an in-depth communication between cells functional would valuable. Herein, we review regulatory role promotion maintenance stem states context repair regeneration. We discuss roles various subsets introduce novel strategies, example, biomaterial-targeting activity, aimed at regulating healing. Understanding crosstalk pathways may shed light on new therapeutic opportunities enhancing through regulation microenvironment.

Language: Английский

Citations

179
COVID-19 and Obesity: Dangerous Liaisons DOI Open Access
Grazia Caci, Adriana Albini, Mario Malerba

et al.

Journal of Clinical Medicine, Journal Year: 2020, Volume and Issue: 9(8), P. 2511 - 2511

Published: Aug. 4, 2020

Besides advanced age and the presence of multiple comorbidities as major contributors to increased risk severe disease fatal outcome from Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) (COVID-19), there is now emerging evidence that overweight obesity predispose symptoms negative prognosis. Remarkably, severity COVID-19 appears rise with increasing body mass index (BMI). The association between outcomes overweight/obesity has biological physiological plausibility. Potential pathophysiological mechanisms may explain this strong include chronic pro-inflammatory state, excessive oxidative stress response, impaired immunity commonly reported in these individuals. role cytokines, mammalian target rapamycin (mTOR), altered natural killer cell polarization dangerous liaison are discussed here. These pathways can favor accelerate deleterious downstream cellular effects SARS-CoV-2. Moreover, well known be associated reduced lung function poor response mechanical ventilation, thus placing individuals at high illness mortality COVID-19. Furthermore, lead other complications, such renal failure, cardiovascular dysfunction, hypertension, vascular damage, which turn further clinical Obese should shielded against any potential viral exposure SARS-CoV-2 consequential considerations for compulsory protection devices social distancing. Health care providers aware predisposes prognosis patients.

Language: Английский

Citations

176