Animal exposure to microplastics and health effects: A review DOI Creative Commons

Eunju Jeong,

Jin‐Yong Lee, Mostafa Redwan

et al.

Emerging contaminants, Journal Year: 2024, Volume and Issue: 10(4), P. 100369 - 100369

Published: May 14, 2024

Microplastic (MP) contamination has become a pervasive global issue, affecting terrestrial and aquatic environments, its potential health hazards are of widespread concern. This review examined the intricate relationship between animal exposure to MPs their effects, revealing that MP affects broad spectrum species across habitats. Crucially, interspecies differences in ingestion, accumulation, responses emerge as central themes arising from various factors, including feeding behavior, physiology, ecological niches. The implications multifarious; animals may suffer physical harm, endure chemical adsorbed contaminants, provoke inflammatory responses, undergo behavioral modifications. Chronic raises concerns about long-term consequences, ability adsorb transport chemicals for bioaccumulation pollutants within food webs. ramifications profound, impacting population dynamics, ecosystem processes. interplay underscores need interdisciplinary research unites fields such biology, ecology, chemistry, toxicology. Recognizing effects significant implications, particularly enter human chain through on risks.

Language: Английский

Osteoarthritis: pathogenic signaling pathways and therapeutic targets DOI Creative Commons
Qing Yao, Xiaohao Wu, Chu Tao

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Feb. 3, 2023

Abstract Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide. OA was believed be caused by the wearing tearing of articular cartilage, but it now commonly referred as whole-joint initiated with biochemical cellular alterations in synovial tissues, which histological structural changes ends up whole tissue dysfunction. Currently, there no cure for OA, partly due lack comprehensive understanding pathological mechanism initiation progression disease. Therefore, better signaling pathways key molecules involved pathogenesis crucial therapeutic target design drug development. In this review, we first summarize epidemiology including its prevalence, incidence burdens, risk factors. We then focus on roles regulation pathways, such Wnt/β-catenin, NF-κB, focal adhesion, HIFs, TGFβ/ΒΜP FGF regulators AMPK, mTOR, RUNX2 onset development OA. addition, factors associated MMPs, ADAMTS/ADAMs, PRG4, are discussed detail. Finally, provide updates current clinical therapies trials biological treatments drugs Research advances basic knowledge cartilage biology will have significant impact translational value developing strategies.

Language: Английский

Citations

580
Mechanisms of action of the erector spinae plane (ESP) block: a narrative review DOI Open Access
Ki Jinn Chin, Kariem El‐Boghdadly

Canadian Journal of Anesthesia/Journal canadien d anesthésie, Journal Year: 2021, Volume and Issue: 68(3), P. 387 - 408

Published: Jan. 6, 2021

Language: Английский

Citations

353
Neuromodulation by the immune system: a focus on cytokines DOI
Andrea Francesca Salvador, Kalil Alves de Lima, Jonathan Kipnis

et al.

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(8), P. 526 - 541

Published: March 1, 2021

Language: Английский

Citations

282
The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes DOI Creative Commons

Amanda Jacobson,

Daping Yang,

Madeleine Vella

et al.

Mucosal Immunology, Journal Year: 2021, Volume and Issue: 14(3), P. 555 - 565

Published: Feb. 4, 2021

The gastrointestinal tract is densely innervated by a complex network of neurons that coordinate critical physiological functions. Here, we summarize recent studies investigating the crosstalk between gut-innervating neurons, resident immune cells, and epithelial cells at homeostasis during infection, food allergy, inflammatory bowel disease. We introduce neuroanatomy tract, detailing gut-extrinsic neuron populations from spinal cord brain stem, intrinsic enteric nervous system. highlight roles these play in regulating functions innate adaptive intestinal cells. discuss consequences such signaling for mucosal immunity. Finally, how microbiota integrated into neuro-immune axis tuning neuronal interactions. Understanding molecular events governing axes will enhance our knowledge physiology may provide novel therapeutic targets to treat diseases.

Language: Английский

Citations

217
Neuro-immune Interactions in the Tissues DOI Creative Commons
Coco Chu, David Artis, Isaac M. Chiu

et al.

Immunity, Journal Year: 2020, Volume and Issue: 52(3), P. 464 - 474

Published: March 1, 2020

Language: Английский

Citations

212
Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons DOI
Chen Ouyang, Christopher R. Donnelly, Ru‐Rong Ji

et al.

Current Opinion in Neurobiology, Journal Year: 2019, Volume and Issue: 62, P. 17 - 25

Published: Dec. 3, 2019

Language: Английский

Citations

207
Tumor Necrosis Factor Receptors: Pleiotropic Signaling Complexes and Their Differential Effects DOI Creative Commons
Portia Gough, Ian A. Myles

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: Nov. 25, 2020

Since its discovery in 1975, TNFα has been a subject of intense study as it plays significant roles both immunity and cancer. Such attention is well deserved unique engagement pleiotropic signaling via two receptors: TNFR1 TNFR2. Extensive research yielded mechanistic insights into how single cytokine can provoke disparate range cellular responses, from proliferation survival to apoptosis necrosis. Understanding the intracellular pathways induced by this receptors key further revelation exact functions many disease states immune responses which role. In review, we describe complexes formed TNFR2 that lead each potential response, namely, canonical non-canonical NF-κB activation, This followed discussion data vivo mouse human studies examine differential impacts versus signaling.

Language: Английский

Citations

203
Neuronal regulation of immunity: why, how and where? DOI
Maya Schiller, Tamar L. Ben-Shaanan, Asya Rolls

et al.

Nature reviews. Immunology, Journal Year: 2020, Volume and Issue: 21(1), P. 20 - 36

Published: Aug. 18, 2020

Language: Английский

Citations

180
STING controls nociception via type I interferon signalling in sensory neurons DOI
Christopher R. Donnelly, Changyu Jiang, Amanda S. Andriessen

et al.

Nature, Journal Year: 2021, Volume and Issue: 591(7849), P. 275 - 280

Published: Jan. 13, 2021

Language: Английский

Citations

171
What causes hidradenitis suppurativa ?—15 years after DOI
Christos C. Zouboulis, Farida Benhadou, Angel S. Byrd

et al.

Experimental Dermatology, Journal Year: 2020, Volume and Issue: 29(12), P. 1154 - 1170

Published: Oct. 15, 2020

The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from 1st International Hidradenitis Suppurativa Research Symposium held March 30-April 2, 2006 Dessau, Germany with 33 participants were prophetic when they wrote "Hopefully, this heralds a welcome new tradition: to get molecular heart HS pathogenesis, which can only be achieved by renaissance solid basic research, as key developing more effective therapy." (Kurzen et al. What causes suppurativa? Exp Dermatol 2008;17:455). Fifteen years later, there is no doubt that desired research progressing rapid steps and has developed deep roots among inflammatory diseases Dermatology beyond, recognized "the skin disease than healed". This anniversary 43 research-performing all around globe official journal European Foundation e.V. (EHSF e.V.) Foundation, Inc (HSF USA) summarizes evidence intense clinical experimental during last 15 aspects provides information developments come near future.

Language: Английский

Citations

150