Biological functions and therapeutic applications of human mucosal-associated invariant T cells DOI Creative Commons

Ying Fang,

Yuning Chen,

Shaoqiang Niu

et al.

Journal of Biomedical Science, Journal Year: 2025, Volume and Issue: 32(1)

Published: March 1, 2025

Abstract Mucosal-associated invariant T (MAIT) cells are a unique subset of innate-like lymphocytes that bridge innate and adaptive immunity. Characterized by their semi-invariant cell receptor (TCR) abundant localization in mucosal tissues, MAIT recognize microbial metabolites, primarily derived from the riboflavin biosynthesis pathway, presented major histocompatibility complex (MHC)-related protein 1 (MR1). This interaction, along with co-stimulatory signals, triggers rapid immune responses, including cytokine secretion cytotoxic activity, highlighting importance maintaining homeostasis combating infections. review provides an in-depth overview biology, development, activation pathways, functional diversity, protective roles immunity, contributions to diseases like cancer inflammatory bowel disease (IBD), context-dependent dual functions health pathology. also highlights emerging therapeutic potential immunotherapy. Their TCR specificity, abundance, tissue-homing properties make them ideal candidates for engineering novel therapies, such as chimeric antigen (CAR)-MAIT cells, targeting infections, cancers, autoimmune diseases. Challenges escape, exhaustion, CAR design optimization must be addressed enhance clinical efficacy. In summary, integral function, presents exciting opportunities treatment wide range Further research is essential unlock full these versatile cells.

Language: Английский

Immune cell-mediated features of non-alcoholic steatohepatitis DOI Creative Commons
Thierry Huby, Emmanuel L. Gautier

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 22(7), P. 429 - 443

Published: Nov. 5, 2021

Non-alcoholic fatty liver disease (NAFLD) includes a range of hepatic manifestations, starting with steatosis and potentially evolving towards non-alcoholic steatohepatitis (NASH), cirrhosis or even hepatocellular carcinoma. NAFLD is major health burden, its incidence increasing worldwide. Although it primarily disturbed metabolism, involves several immune cell-mediated inflammatory processes, particularly when reaching the stage NASH, at which point inflammation becomes integral to progression disease. The cell landscape diverse steady state further evolves during NASH direct consequences for severity. In this Review, we discuss current concepts related role cells in onset NASH. A better understanding mechanisms by contribute pathogenesis should aid design innovative drugs target therapeutic options are limited. (NASH) serious chronic disorder prevalence Metabolic nature, also mobilizes system. Here, Huby Gautier knowledge regarding how subsets affect progression.

Language: Английский

Citations

391
Hepatic inflammatory responses in liver fibrosis DOI
Linda Hammerich, Frank Tacke

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 20(10), P. 633 - 646

Published: July 3, 2023

Language: Английский

Citations

322
Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease – novel insights into cellular communication circuits DOI Creative Commons
Moritz Peiseler, Robert F. Schwabe, Jochen Hampe

et al.

Journal of Hepatology, Journal Year: 2022, Volume and Issue: 77(4), P. 1136 - 1160

Published: June 22, 2022

Language: Английский

Citations

312
An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH DOI Open Access
Frank Tacke, Tobias Puengel, Rohit Loomba

et al.

Journal of Hepatology, Journal Year: 2023, Volume and Issue: 79(2), P. 552 - 566

Published: April 14, 2023

Language: Английский

Citations

165
Immunological mechanisms and therapeutic targets of fatty liver diseases DOI Creative Commons
Hua Wang, Wajahat Z. Mehal, Laura E. Nagy

et al.

Cellular and Molecular Immunology, Journal Year: 2020, Volume and Issue: 18(1), P. 73 - 91

Published: Dec. 2, 2020

Abstract Alcoholic liver disease (ALD) and nonalcoholic fatty (NAFLD) are the two major types of chronic worldwide. Inflammatory processes play key roles in pathogeneses diseases, continuous inflammation promotes progression alcoholic steatohepatitis (ASH) (NASH). Although both ALD NAFLD closely related to inflammation, their respective developmental mechanisms differ some extent. Here, we review multiple immunological therapeutic targets associated with diseases differences ASH NASH. Multiple cell liver, including macrophages, neutrophils, other immune hepatocytes, involved inflammation. In addition, microRNAs (miRNAs), extracellular vesicles (EVs), complement also contribute inflammatory process, as does intertissue crosstalk between intestine, adipose tissue, nervous system. We point out that plays important promoting repair controlling bacterial infections. Understanding complex regulatory process disrupted homeostasis during development may lead improved targeted intervention strategies.

Language: Английский

Citations

157
MAIT Cell Development and Functions: the Microbial Connection DOI Creative Commons
François Legoux, Marion Salou, Olivier Lantz

et al.

Immunity, Journal Year: 2020, Volume and Issue: 53(4), P. 710 - 723

Published: Oct. 1, 2020

Language: Английский

Citations

149
γδ T cells: origin and fate, subsets, diseases and immunotherapy DOI Creative Commons
Yi Hu,

Qinglin Hu,

Yongsheng Li

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 22, 2023

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential renormalization as a promising strategy in disease treatment. In recent years, our primary focus has centered on γδ T cell-based immunotherapy, particularly pioneering use allogeneic Vδ2

Language: Английский

Citations

113
T Cell Responses to the Microbiota DOI
Ivaylo I. Ivanov, Timur Tuganbaev, Ashwin N. Skelly

et al.

Annual Review of Immunology, Journal Year: 2022, Volume and Issue: 40(1), P. 559 - 587

Published: Feb. 3, 2022

The immune system employs recognition tools to communicate with its microbial evolutionary partner. Among all the methods of perception, T cells enable widest spectrum resolution, ranging from crudest detection whole groups microbes finest specific antigens. application this capability crucial task combatting infections has been focus classical immunology. We now appreciate that coevolution and microbiota led development a lush immunological decision tree downstream recognition, which an inflammatory response is but one branch. In review we discuss known cell-microbe interactions in gut place them context algorithmic framework context-dependent interpretation, circuits across multiple levels resolution. malleability presents opportunity edit cellularity, identity, functionality by utilizing microbiota-controlled pathways promote human health.

Language: Английский

Citations

84
Liver fibrosis in NAFLD/NASH: from pathophysiology towards diagnostic and therapeutic strategies DOI Creative Commons
Maurizio Parola, Massimo Pinzani

Molecular Aspects of Medicine, Journal Year: 2023, Volume and Issue: 95, P. 101231 - 101231

Published: Dec. 5, 2023

Liver fibrosis, as an excess deposition of extracellular matrix (ECM) components, results from chronic liver injury well persistent activation inflammatory response and fibrogenesis. fibrosis is a major determinant for disease (CLD) progression in the last two decades our understanding on molecular cellular mechanisms underlying fibrogenic CLD has dramatically improved, boosting pre-clinical studies clinical trials designed to find novel therapeutic approaches. From these several critical concepts have emerged, starting reveal complexity pro-fibrotic microenvironment which involves very complex, dynamic interrelated interactions between different hepatic extrahepatic cell populations. This review will offer first recapitulation established pathophysiological basic principles by intentionally focus attention NAFLD/NASH, metabolic-related form with high impact general population emerging leading cause worldwide. NAFLD/NASH-related pro-inflammatory profibrogenic be analysed information cells, mediators signalling pathways taken advantage methodological approaches techniques (single genomics, imaging mass cytometry, vitro two- three-dimensional models, etc.). We next overview recent advancement diagnostic prognostic tools, including serum biomarkers polygenic scores, support analysis biopsies. Finally, this provide current therapies treatment NAFLD/NASH patients.

Language: Английский

Citations

70
Innate lymphoid cells and innate-like T cells in cancer — at the crossroads of innate and adaptive immunity DOI
Benjamin Ruf, Tim F. Greten, Firouzeh Korangy

et al.

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(6), P. 351 - 371

Published: April 20, 2023

Language: Английский

Citations

52