Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis

Allergy, Journal Year: 2023, Volume and Issue: 78(5), P. 1169 - 1203

Published: Feb. 17, 2023

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach links between upper- lower-airway allergic diseases. With new data, it time to reassess concept. This article reviews (i) observations led Allergic Rhinitis its Impact on Asthma (ARIA), (ii) insights into polysensitization multimorbidity, (iii) advances mHealth for novel phenotype definitions, (iv) confirmation canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, (vii) concepts onset rhinitis multimorbidity. One recent concept, bringing together diseases with skin, gut, neuropsychiatric multimorbidities, "Epithelial Barrier Hypothesis." review determined "one-airway-one-disease" does not always hold true several disease can be defined. These include an extreme "allergic" (asthma) combining asthma, conjunctivitis. alone asthma multimorbidity represent two distinct following differences: transcriptomic background (Toll-Like Receptors IL-17 as local disease; IL-33 IL-5 non-allergic systemic disease), allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), severity symptoms, response. In conclusion, (local disease) (systemic should considered diseases, possibly modulated by microbiome, may model understanding epidemics chronic autoimmune

Language: Английский

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A precision environmental health approach to prevention of human disease

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: April 28, 2023

Abstract Human health is determined by the interaction of our environment with genome, epigenome, and microbiome, which shape transcriptomic, proteomic, metabolomic landscape cells tissues. Precision environmental an emerging field leveraging system-level (‘omic) data to understand underlying causes disease, identify biomarkers exposure response, develop new prevention intervention strategies. In this article we provide real-life illustrations utility precision approaches, current challenges in field, outline opportunities promote through a framework.

Language: Английский

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The Devastation of Waste Plastic on the Environment and Remediation Processes: A Critical Review

Sustainability, Journal Year: 2023, Volume and Issue: 15(6), P. 5233 - 5233

Published: March 15, 2023

The devastating effect of plastic waste on the ecosystem due to rapid increase in population has been a concern. Although stakeholders and governments invested efforts mitigate waste, their exertions have limited no effects as demand for increases annually. Emerging practical advancements recycling critical achieving sustainable circular economy. This study reviews adverse environment inhabiting creature, regulation managing limitations. scoping review also provides information current route reducing by defining its sources applications. After identifying generation polymers are categorized according hazard ranking monomers environmental toxicity, damaging creature. discharge pathways into aquatic systems leading white pollution climate change were determined. Conversion through remedial channel manufacturing value-added products using techniques such reusing, recycling, energy recovery, disposal landfills is outlined. processes provided this will help reduce from environment. In addition, correctly applying these suggestions may death creations. Further research necessary convert raw materials high-value achieve

Language: Английский

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Akkermansia muciniphila exacerbates food allergy in fibre-deprived mice

Nature Microbiology, Journal Year: 2023, Volume and Issue: 8(10), P. 1863 - 1879

Published: Sept. 11, 2023

Abstract Alterations in the gut microbiome, including diet-driven changes, are linked to rising prevalence of food allergy. However, little is known about how specific bacteria trigger breakdown oral tolerance. Here we show that depriving specific-pathogen-free mice dietary fibre leads a microbiota signature with increases mucin-degrading bacterium Akkermansia muciniphila . This associated intestinal barrier dysfunction, increased expression type 1 and 2 cytokines IgE-coated commensals colon, which result an exacerbated allergic reaction allergens, ovalbumin peanut. To demonstrate causal role A. , employed tractable synthetic human gnotobiotic mice. The presence within microbiota, combined deprivation, resulted stronger anti-commensal IgE coating innate type-2 immune responses, worsened symptoms Our study provides important insights into microbes can regulate pathways allergy diet-dependent manner.

Language: Английский

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Decoding the genetic and epigenetic basis of asthma

Allergy, Journal Year: 2023, Volume and Issue: 78(4), P. 940 - 956

Published: Feb. 2, 2023

Abstract Asthma is a complex and heterogeneous chronic inflammatory disease of the airways. Alongside environmental factors, asthma susceptibility strongly influenced by genetics. Given its high prevalence our incomplete understanding mechanisms underlying susceptibility, frequently studied in genome‐wide association studies (GWAS), which have identified thousands genetic variants associated with development. Virtually all these reside non‐coding genomic regions, has obscured functional impact asthma‐associated their translation into disease‐relevant mechanisms. Recent advances genomics technology epigenetics now offer methods to link gene regulatory elements embedded within started unravel molecular (epi)genetics asthma. Here, we provide an integrated overview (epi)genetic asthma, focusing on efforts associations biological insight pathophysiology using state‐of‐the‐art methodology. Finally, perspective as how decoding epigenetic basis potential transform clinical management predict risk

Language: Английский

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