Decidual stromal cells: fibroblasts specialized in immunoregulation during pregnancy

Trends in Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Exploring Potential Biomarkers in Recurrent Pregnancy Loss: A Literature Review of Omics Studies to Molecular Mechanisms

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2263 - 2263

Published: March 4, 2025

Recurrent pregnancy loss (RPL) is characterized by the occurrence of three or more consecutive spontaneous losses before 20-24 weeks gestation. Despite significant progress in investigation biological pathways associated with unexplained RPL, precise molecular mechanisms remain elusive. Recent advances multi-omics approaches have identified numerous biomarkers that offer potential avenues for understanding underlying complexities RPL. The aim this comprehensive literature review was to investigate functional roles these candidate markers and explore possible key may contribute We also aimed elucidate networks predicted omics analyses, which hold promise providing invaluable insights into novel diagnostic therapeutic strategies women experiencing Furthermore, expands on clinical implications applications, highlighting those currently moving towards use ongoing studies developing direction.

Language: Английский

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Enhancing understanding of endometrial function in patients with PCOS: clinical and immunological insights

Journal of Ovarian Research, Journal Year: 2025, Volume and Issue: 18(1)

Published: March 12, 2025

To evaluate the pregnancy and perinatal outcomes of different phenotypes polycystic ovary syndrome (PCOS) patients during frozen embryo transfer (FET) cycles. Additionally, to analyze T cell balance in endometrium PCOS explore its relationship with various phenotypes. Retrospective cohort study. A single academically affiliated reproductive medicine center. 21,074 FET cycles were included divided into two groups based on diagnosis PCOS. Patients further categorized four phenotypic groups: PCOM + HA OA, HA, OA. Endometrial biopsies from 21 26 controls obtained subsets. Pregnancy outcomes, as well subset abundance compared between women without Multiple logistic regression models employed adjust for confounding factors impacting pregnancy-related outcomes. Flow cytometry was utilized assessed. subsets including CD4+CD8−T cells, CD4−CD8+T Th1, Th2, Th17 Treg cells determined by flow cytometry. There a significantly increased incidence miscarriage, hypertensive disorders (HDP), preterm birth (PTB), even fetal malformations across women, especially those hyperandrogenic phenotype. Th1 decreased while Th2 endometrium. The unfavorable imbalance both suggest endometrial dysfunction patients,

Language: Английский

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Ethical considerations for advancing research using organoid models derived from the placenta

Human Reproduction Update, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract BACKGROUND The advent of organoid culture systems has revolutionized our ability to model and study complex tissues in vitro. placenta is one the last human organs have a functional developed: trophoblast organoids. These 3-dimensional structures, derived from placental tissue, offer researchers valuable tool for studying previously inaccessible processes that occur within womb play significant role determining health offspring. While primarily used research, organoids hold promise clinical applications, including prenatal diagnostics therapeutic interventions, both which may commercial interest. However, ensure research with models conducted responsibly, relevant ethics these need be addressed. OBJECTIVE AND RATIONALE Ethical considerations related placenta, such as are important but remain unexplored literature. Therefore, goal this review explore ethical SEARCH METHODS Since there no specifically addressing date, we based findings on discussions other involving fetal or umbilical cord blood. We employed scoping method search PubMed, Embase, Medline (all), Bioethics Research Library, Google Scholar articles, books, correspondence issues regarding indicated topics, date limits. OUTCOMES can divided into three distinct categories. First, assess moral value organoids, their potential relational symbolic dimensions. Second, it understand associated ownership commercialization Last, appropriate informed consent procedures. It worth noting categories interconnected, second third being largely dependent attributed Future should perspectives various stakeholders, parents who donate tissue research. WIDER IMPLICATIONS This offers insights landscape surrounding derivation products pregnancies, further application, highlighting areas require attention discussion scientific community broader society. REGISTRATION NUMBER N/A.

Language: Английский

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The revolutionary role of placental derivatives in biomedical research

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 456 - 485

Published: March 19, 2025

Language: Английский

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