Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 17, 2023
Dendritic
cells
(DCs),
central
participants
in
the
allergic
immune
response,
can
capture
and
present
allergens
leading
to
inflammation
immunopathogenesis
of
rhinitis
(AR).
In
addition
initiating
antigen-specific
responses,
DCs
induce
tolerance
modulate
homeostasis.
As
a
special
type
DCs,
tolerogenic
(tolDCs)
achieve
mainly
by
suppressing
effector
T
cell
responses
inducing
regulatory
(Tregs).
TolDCs
suppress
modulating
tolerance,
thereby
reducing
symptoms
AR.
Activation
TLR4/IRAK4/NF-κB
signaling
pathway
contributes
release
inflammatory
cytokines,
inhibitors
this
production
tolDCs
alleviate
responses.
This
review
focuses
on
relationship
between
with
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(36), P. 24650 - 24681
Published: Aug. 26, 2024
Multiple
vaccine
platforms
have
been
employed
to
develop
the
nasal
SARS-CoV-2
vaccines
in
preclinical
studies,
and
dominating
pipelines
are
viral
vectored
as
protein-based
vaccines.
Among
them,
several
vectored-based
entered
clinical
development.
Nevertheless,
some
unsatisfactory
results
were
reported
these
studies.
In
face
of
such
urgent
situations,
it
is
imperative
rapidly
next-generation
intranasal
COVID-19
utilizing
other
technologies.
Nanobased
emerged
an
approach
against
respiratory
infectious
diseases.
Harnessing
power
nanotechnology,
offer
a
noninvasive
yet
potent
defense
pathogens,
including
threat
COVID-19.
The
improvements
made
mucosal
delivery
technologies
based
on
nanoparticles,
lipid
polymeric
inorganic
nanoparticles
etc.,
not
only
provide
stability
controlled
release
but
also
enhance
adhesion,
effectively
overcoming
limitations
conventional
Hence,
this
review,
we
overview
evaluation
highlight
current
barriers.
Next,
modern
systems
nanoplatforms
summarized.
challenges
application
nanoplatform
finally
discussed.
European Journal of Immunology,
Journal Year:
2023,
Volume and Issue:
53(10)
Published: July 25, 2023
Antigen-specific
T
lymphocytes
are
the
central
regulators
of
tolerance
versus
immune
pathology
against
otherwise
innocuous
antigens
and
key
targets
antigen-specific
therapy.
Recent
advances
in
understanding
cells
allergy
resulted
from
improved
technologies
to
directly
characterize
allergen-specific
by
multiparameter
flow
cytometry
or
single-cell
sequencing.
This
unravelled
phenotypically
functionally
distinct
populations,
such
as
Type
2a
helper
(Th2a),
follicular
Th
(Tfh),
regulatory
(Treg),
1
(Tr1),
cells.
Here
we
will
discuss
role
different
Th-cell
subsets
healthy
state,
during
sensitization
development
allergy,
induction
allergen
immunotherapy
(AIT).
To
date,
mechanisms
AIT
only
causal
treatment
not
completely
understood.
The
analyses
ex
vivo
support
concept
specific-Th2(a)
cell
deletion
rather
than
an
expansion
Tr1
Treg
underlying
mechanism.
Allergy,
Journal Year:
2023,
Volume and Issue:
78(12), P. 3136 - 3153
Published: Sept. 13, 2023
Abstract
Background
The
nature
of
epitopes
on
Bet
v
1
recognized
by
natural
IgG
antibodies
birch
pollen
allergic
patients
and
pollen‐exposed
but
non‐sensitized
subjects
has
not
been
studied
in
detail.
Objective
To
investigate
IgE
recognition
to
study
the
effects
1‐specific
1‐induced
basophil
activation.
Methods
Sera
from
(BPA,
n
=
76),
without
allergy
(NBPA,
40)
non‐allergic
individuals
(NA,
48)
were
tested
for
IgE,
as
well
4
reactivity
folded
recombinant
1,
two
unfolded
fragments
comprising
N‐terminal
(F1)
C‐terminal
half
(F2)
peptides
spanning
corresponding
sequences
apple
allergen
Mal
d
ELISA
or
micro‐array
analysis.
ability
serum
inhibit
binding
rBet
1‐derivatives
was
assessed
competition
ELISAs.
Furthermore,
modulate
activation
investigated
using
rat
basophilic
leukaemia
cells
expressing
human
FcεRI
which
had
loaded
with
BPA
patients.
Results
react
almost
exclusively
conformational
whereas
IgG,
BPA,
NBPA
NA
recognize
mainly
sequential
epitopes.
studies
show
that
specific
unfolded/sequential
is
inhibited
hence
latter
seem
represent
cryptic
did
correlate
therefore
does
be
a
result
primary
sensitization
PR10
allergen‐containing
food.
Natural
only
poorly
could
even
enhance
Conclusion
different
These
findings
explain
why
allergen‐specific
do
protect
against
symptoms
suggest
have
clonal
origin.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 17, 2023
Dendritic
cells
(DCs),
central
participants
in
the
allergic
immune
response,
can
capture
and
present
allergens
leading
to
inflammation
immunopathogenesis
of
rhinitis
(AR).
In
addition
initiating
antigen-specific
responses,
DCs
induce
tolerance
modulate
homeostasis.
As
a
special
type
DCs,
tolerogenic
(tolDCs)
achieve
mainly
by
suppressing
effector
T
cell
responses
inducing
regulatory
(Tregs).
TolDCs
suppress
modulating
tolerance,
thereby
reducing
symptoms
AR.
Activation
TLR4/IRAK4/NF-κB
signaling
pathway
contributes
release
inflammatory
cytokines,
inhibitors
this
production
tolDCs
alleviate
responses.
This
review
focuses
on
relationship
between
with
