International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2369 - 2369
Published: Feb. 17, 2024
Inflammasomes
are
multimeric
protein
complexes,
sensors
of
intracellular
danger
signals,
and
crucial
components
the
innate
immune
system,
with
NLRP3
inflammasome
being
best
characterized
among
them.
The
increasing
scientific
interest
in
mechanisms
interconnecting
inflammation
tumorigenesis
has
led
to
study
setting
various
neoplasms.
Despite
a
plethora
data
regarding
solid
tumors,
inflammasome’s
implication
pathogenesis
hematological
malignancies
only
recently
gained
attention.
In
this
review,
we
investigate
its
role
normal
lymphopoiesis
lymphomagenesis.
Considering
that
lymphomas
comprise
heterogeneous
group
hematologic
neoplasms,
both
tumor-promoting
tumor-suppressing
properties
were
attributed
inflammasome,
affecting
neoplastic
cells
tumor
microenvironment.
inflammasome-related
proteins
associated
disease
characteristics,
response
treatment,
prognosis.
Few
studies
assess
efficacy
therapeutic
targeting
encouraging
results,
though
most
still
at
preclinical
level.
Further
understanding
regulating
activation
during
lymphoma
development
progression
can
contribute
investigation
novel
treatment
approaches
cover
unmet
needs
therapeutics.
Nature,
Journal Year:
2023,
Volume and Issue:
622(7982), P. 339 - 347
Published: Oct. 4, 2023
Integrating
human
genomics
and
proteomics
can
help
elucidate
disease
mechanisms,
identify
clinical
biomarkers
discover
drug
targets1-4.
Because
previous
proteogenomic
studies
have
focused
on
common
variation
via
genome-wide
association
studies,
the
contribution
of
rare
variants
to
plasma
proteome
remains
largely
unknown.
Here
we
associations
between
protein-coding
2,923
protein
abundances
measured
in
49,736
UK
Biobank
individuals.
Our
variant-level
exome-wide
study
identified
5,433
genotype-protein
associations,
which
81%
were
undetected
a
same
cohort5.
We
then
looked
at
aggregate
signals
using
gene-level
collapsing
analysis,
revealed
1,962
gene-protein
associations.
Of
691
from
protein-truncating
variants,
99.4%
associated
with
decreased
levels.
STAB1
STAB2,
encoding
scavenger
receptors
involved
clearance,
emerged
as
pleiotropic
loci,
77
41
respectively.
demonstrate
utility
our
publicly
accessible
resource
through
several
applications.
These
include
detailing
an
allelic
series
NLRC4,
identifying
potential
for
fatty
liver
disease-associated
variant
HSD17B13
bolstering
phenome-wide
by
integrating
quantitative
trait
loci
analyses.
Finally,
uncover
distinct
proteomic
consequences
clonal
haematopoiesis
(CH),
including
TET2-CH
increased
FLT3
results
highlight
considerable
role
abundance
value
proteogenomics
therapeutic
discovery.
New England Journal of Medicine,
Journal Year:
2024,
Volume and Issue:
390(22), P. 2047 - 2060
Published: June 12, 2024
The
risk
of
second
tumors
after
chimeric
antigen
receptor
(CAR)
T-cell
therapy,
especially
the
neoplasms
related
to
viral
vector
integration,
is
an
emerging
concern.
Annual Review of Immunology,
Journal Year:
2024,
Volume and Issue:
42(1), P. 455 - 488
Published: Feb. 16, 2024
Ten-eleven
translocation
(TET)
proteins
are
iron-dependent
and
α-ketoglutarate-dependent
dioxygenases
that
sequentially
oxidize
the
methyl
group
of
5-methylcytosine
(5mC)
to
5-hydroxymethylcytosine
(5hmC),
5-formylcytosine
(5fC)
5-carboxylcytosine
(5caC).
All
three
epigenetic
modifications
intermediates
in
DNA
demethylation.
TET
recruited
by
transcription
factors
RNA
polymerase
II
modify
5mC
at
enhancers
gene
bodies,
thereby
regulating
expression
during
development,
cell
lineage
specification,
activation.
It
is
not
yet
clear,
however,
how
established
biochemical
activities
enzymes
oxidizing
mediating
demethylation
relate
known
association
deficiency
with
inflammation,
clonal
hematopoiesis,
cancer.
There
hints
ability
promote
proliferation
a
signal-dependent
manner
may
be
harnessed
for
cancer
immunotherapy.
In
this
review,
we
draw
upon
recent
findings
cells
immune
system
illustrate
as
well
emerging
ideas
influence
cellular
function.
Nature,
Journal Year:
2023,
Volume and Issue:
618(7966), P. 834 - 841
Published: June 7, 2023
Tumours
most
often
arise
from
progression
of
precursor
clones
within
a
single
anatomical
niche.
In
the
bone
marrow,
clonal
progenitors
can
undergo
malignant
transformation
to
acute
leukaemia,
or
differentiate
into
immune
cells
that
contribute
disease
pathology
in
peripheral
tissues
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 24, 2023
Multicellular
organisms
are
constantly
subjected
to
pathogens
that
might
be
harmful.
Although
insects
lack
an
adaptive
immune
system,
they
possess
highly
effective
anti-infective
mechanisms.
Bacterial
phagocytosis
and
parasite
encapsulation
some
forms
of
cellular
responses.
Insects
often
defend
themselves
against
infections
through
a
humoral
response.
This
phenomenon
includes
the
secretion
antimicrobial
peptides
into
hemolymph.
Specific
receptors
for
detecting
infection
required
recognition
foreign
such
as
proteins
recognize
glucans
peptidoglycans,
together
referred
PGRPs
βGRPs.
Activation
these
leads
stimulation
signaling
pathways
which
further
activates
genes
encoding
peptides.
Some
instances
JAK-STAT,
Imd,
Toll.
The
host
response
frequently
accompanies
has,
however,
been
circumvented
by
diseases,
may
have
assisted
evolve
their
own
complicated
systems.
role
ncRNAs
in
insect
immunology
has
discussed
several
notable
studies
reviews.
paper
examines
most
recent
research
on
regulatory
function
during
insect-pathogen
crosstalk,
including
insect-
pathogen-encoded
miRNAs
lncRNAs,
provides
overview
important
effector
mechanisms
activated
diverse
pathogen
invaders.
Science,
Journal Year:
2024,
Volume and Issue:
386(6718)
Published: Oct. 10, 2024
Epigenetic
reinforcement
of
T
cell
exhaustion
is
known
to
be
a
major
barrier
limiting
responses
during
immunotherapy.
However,
the
core
epigenetic
regulators
restricting
antitumor
immunity
prolonged
antigen
exposure
are
not
clear.
We
investigated
three
commonly
mutated
that
promote
clonal
hematopoiesis
determine
whether
they
affect
stemness
and
response
checkpoint
blockade
CD8
cells
lacking
Dnmt3a,
Tet2,
or
Asxl1
preserved
progenitor-exhausted
(Tpex)
population
for
more
than
1
year
chronic
without
undergoing
malignant
transformation.
controlled
self-renewal
capacity
reduced
differentiation
through
H2AK119
ubiquitination
modification
polycomb
group–repressive
deubiquitinase
pathway.
Asxl1-deficient
synergized
with
anti–PD-L1
immunotherapy
improve
tumor
control
in
experimental
models
conferred
survival
advantage
from
treated
patients.
