Nature reviews. Cancer, Journal Year: 2025, Volume and Issue: unknown
Published: June 3, 2025
Language: Английский
Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(8), P. 523 - 539
Published: July 8, 2024
Language: Английский
Citations
65
Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(6), P. 453 - 469
Published: April 4, 2024
Language: Английский
Citations
27
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(24)
Published: April 3, 2024
Abstract Glioblastoma (GBM) is the most aggressive and prevalent primary malignant tumor of central nervous system. Traditional chemotherapy has poor therapeutic effects significant side due to drug resistance, natural blood‐brain barrier (BBB), nonspecific distribution, leading a lack clinically effective drugs. Here, 1430 small molecule compounds are screened based on high‐throughput screening platform novel anti‐GBM drug, lomitapide (LMP) obtained. Furthermore, bionic nanodrug delivery system (RFA NPs) actively targeting GBM constructed, which mainly consists tetrahedral DNA nanocages (tFNA loaded with LMP as core folate‐modified erythrocyte–cancer cell–macrophage hybrid membrane (FRUR) shell. FRUR camouflage conferred unique features tFNA NPs, including excellent biocompatibility, improved pharmacokinetic profile, efficient BBB permeability, ability. The results show that RFA NPs exhibited superior specific activities, reduced off‐target delivery, prolonged lifespan, negligible in tumor‐bearing mice. This study combines biomimetic technology provide theoretical practical basis for development optimization clinical treatment strategies treatment.
Language: Английский
Citations
20
Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123136 - 123136
Published: Jan. 1, 2025
Language: Английский
Citations
4
International Journal of Surgery, Journal Year: 2024, Volume and Issue: 110(10), P. 6748 - 6762
Published: June 21, 2024
The advent of personalized bone prosthesis materials and their integration into orthopedic surgery has made a profound impact, primarily as result the incorporation three-dimensional (3D) printing technology. By leveraging digital models additive manufacturing techniques, 3D enables creation customized, high-precision implants tailored to address complex anatomical variabilities challenging defects. In this review, we highlight significant progress in utilizing printed prostheses across wide range procedures, including pelvis, hip, knee, foot, ankle, spine surgeries, tumor resections. preoperative planning, surgical navigation, postoperative rehabilitation not only enhances treatment outcomes but also reduces risks, accelerates recovery, optimizes cost-effectiveness. Emphasizing potential for care improved patient outcomes, review underscores pivotal role advancing practice towards precision, efficiency, patient-centric solutions. evolving landscape holds promise revolutionizing approaches, enhancing ultimately improving quality patients.
Language: Английский
Citations
10
Science Advances, Journal Year: 2024, Volume and Issue: 10(29)
Published: July 19, 2024
Current in vitro models struggle to balance the complexity of human diseases with suitability for large-scale drug tests. While 3D cultures simulate tissues, they lack cellular intricacy, and integrating these high-throughput screening remains a challenge. Here, we introduce method that uses self-assembling nucleic acid nanostructures decorated living cells, termed NACs, create spheroids customizable layout. To demonstrate its uniqueness, our effectively creates designer by combining parenchymal stromal immune leading heightened physiological relevance detailed modeling complex chronic immune-stromal interactions. Our approach achieves high level biological fidelity while being standardized straightforward construct potential discovery applications. By merging precision DNA nanotechnology advanced cell culture techniques, are streamlining human-centric models, striking between standardization, boost efficiency.
Language: Английский
Citations
7
Cells, Journal Year: 2025, Volume and Issue: 14(1), P. 38 - 38
Published: Jan. 2, 2025
Haematological malignancies comprise a diverse group of life-threatening systemic diseases, including leukaemia, lymphoma, and multiple myeloma. Currently available therapies, chemotherapy, immunotherapy, CAR-T cells, are often associated with important side effects the development drug resistance and, consequently, disease relapse. In last decades, it was largely demonstrated that tumor microenvironment significantly affects cancer cell proliferation response to treatment. The biomimetic, in vitro models may promote investigation interactions between cells help better understand mechanisms leading resistance. Although advanced have been explored field solid tumors, due complex nature blood microenvironment, mimicking haematological mostly relies on simpler systems, limited two-dimensional culture, which intrinsically excludes microenvironmental niche, or ethically debated animal models. This review aims at reporting an updated overview state-of-the-art hematological 3D models, emphasizing key features limitations existing systems inspire further research this underexplored field.
Language: Английский
Citations
1
Oncogene, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 25, 2025
Genome-wide functional genetic screening has been widely used in the biomedicine field, which makes it possible to find a needle haystack at level. In cancer research, gene mutations are closely related tumor development, metastasis, and recurrence, use of state-of-the-art powerful technologies, such as clustered regularly interspaced short palindromic repeat (CRISPR), search for most critical genes or coding products provides us with new possibility further refine mapping provide possibilities treatment patients. The CRISPR refined atlas provided Immunotherapy, highly promising method, validated clinic, but could only meet needs small proportion Finding immunotherapy targets is key future immunotherapy. Here, we revisit application immunology from different perspectives, selection diverse vitro vivo models potential immune checkpoints potentiating CAR-T cells. data will offer fresh therapeutic clues
Language: Английский
Citations
1
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: April 26, 2025
Gastric cancer (GC) is a prevalent digestive system tumor, the fifth most diagnosed worldwide, and leading cause of deaths. GC distinguished by its pronounced heterogeneity dynamically evolving tumor microenvironment (TME). The lack accurate disease models complicates understanding mechanisms impedes discovery novel drugs. A growing body evidence suggests that organoids, developed using organoid culture technology, preserve genetic, phenotypic, behavioral characteristics. organoids hold significant potential for predicting treatment responses in individual patients. This review provides comprehensive overview current clinical strategies GC, as well history, construction applications organoids. focus on role simulating TME to explore immune evasion intratumoral microbiota their guiding drug therapy facilitating screening. Furthermore, we summarize limitations underscore need continued technological advancements benefit both basic translational oncological research.
Language: Английский
Citations
1
Cellular Oncology, Journal Year: 2024, Volume and Issue: 47(4), P. 1113 - 1126
Published: March 23, 2024
Cancer immunotherapy is receiving worldwide attention for its induction of an anti-tumor response. However, it has had limited efficacy in some patients who acquired resistance. The dynamic and sophisticated complexity the tumor microenvironment (TME) leading contributor to this clinical dilemma. Through recapitulating physiological features TME, 3D bioprinting a promising research tool cancer immunotherapy, which preserves vivo malignant aggressiveness, heterogeneity, cell-cell/matrix interactions. It been reported that application holds potential address challenges resistance facilitate personalized medication.
Language: Английский
Citations
6