Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Cancer Cell, Journal Year: 2024, Volume and Issue: 42(11), P. 1825 - 1863
Published: Oct. 10, 2024
Language: Английский
Citations
57
Cell Reports, Journal Year: 2025, Volume and Issue: 44(1), P. 115206 - 115206
Published: Jan. 1, 2025
Language: Английский
Citations
3
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Abstract The cGAS‐STING pathway is pivotal in initiating antitumor immunity. However, tumor metabolism, particularly glycolysis, negatively regulates the activation of pathway. Herein, Mn galvanic cells (MnG) are prepared via liquid‐phase exfoliation and situ replacement to modulate thereby enhancing for bidirectional synergistic H 2 ‐immunotherapy. obtained MnG can be etched by water, enabling efficient sustained generation gas 2+ . not only activated amplified through release but also regulated glucose metabolism inhibit expression three prime repair exonuclease (TREX2), synergistically injection into tumors resulted a robust immune response, providing favorable support therapy. Consequently, combination with checkpoint blockade therapy significant suppression both primary distant tumors. Furthermore, MnG‐lipiodol dispersion exhibited remarkable efficacy transarterial embolization (TAE)‐gas‐immunotherapy rabbit orthotopic liver model. present study underscores significance employing metal cell strategy enhanced immunotherapy, offering novel approach rational design bioactive materials augment immunotherapeutic effectiveness.
Language: Английский
Citations
1
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: Jan. 30, 2025
The progression of bladder cancer (BC) from non-muscle-invasive (NMIBC) to muscle-invasive (MIBC) significantly increases disease severity. Although the tumor microenvironment (TME) plays a pivotal role in this process, heterogeneity cells and TME components remains underexplored. We characterized transcriptomes single 11 BC samples, including 4 NMIBC, MIBC, 3 adjacent normal tissues. Bulk RNA-seq data were used validate clinical features characteristic cells, protein levels these further confirmed through immunohistochemistry (IHC) multiplex immunofluorescence. Bladder was associated with distinct transcriptomic TME. Tumor MIBC displayed enhanced glycolytic activity downregulation chemokines MHC-II molecules, reducing immune cell recruitment facilitating evasion. This highlights glycolysis as potential therapeutic target for disrupting progression. identified T exhaustion pathway naive CD8 + (CD8 TCF7) terminally exhausted STMN1 progressively declining surveillance. Targeting intermediate states may restore function improve anti-tumor immunity. Macrophages polarized toward pro-tumorigenic phenotype, while VEGFA mast promoted angiogenesis early-stage BC, suggesting their targets intervention NMIBC. Furthermore, conventional dendritic (DCs) transformed into LAMP3 DCs, contributing an immunosuppressive enabling study reveals dynamic changes during progression, glycolysis, exhaustion, remodeling, which contribute evasion These findings identify critical pathways populations targets, offering new strategies treatment outcomes patients.
Language: Английский
Citations
1
Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
1
Methods in cell biology, Journal Year: 2025, Volume and Issue: unknown, P. 109 - 118
Published: Jan. 1, 2025
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2025, Volume and Issue: 33(1), P. 200933 - 200933
Published: Jan. 14, 2025
Metabolic features are crucial in tumor immune interactions, but their relationship with antitumor responses is not yet fully understood. This study used Mendelian randomization analysis to identify the causal relationships between blood metabolites and cells evaluate effects of metabolic pathways reactions on various cancers. Levels 156 exhibited significant associations selected cells. enrichment indicated laurate, propionyl-carnitine, carnitine l-acetylcarnitine enriched fatty acid (FA) metabolism pathways. These significantly correlated CD8+ T cell function signatures environment favor better prognostic outcomes. contributing immunotherapy were identified establish immuno-metabolic reaction score (IMRS). IMRS infiltration levels signature scores either 10× Visium spatial transcriptomic or RNA-seq samples. Finally, could predict favorable survival outcomes different cancer patients treated immunotherapy. Our revealed a link certain related landscape functions. results promote accurate stratification before treatment improve efficacy
Language: Английский
Citations
0
World Journal of Gastrointestinal Oncology, Journal Year: 2025, Volume and Issue: 17(2)
Published: Jan. 18, 2025
The nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome is a critical modulator in inflammatory disease. Activation mutation of NLRP3 can cause severe inflammation diseases such as chronic infantile neurologic cutaneous articular syndrome, Muckle-Wells familial cold autoinflammatory syndrome 1. To date, great effort has been made to decode the underlying mechanisms activation. priming activation drive maturation release active interleukin (IL)-18 IL-1β pyroptosis, which significantly trigger many including diseases, immune disorders, metabolic neurodegenerative diseases. investigation therapeutic target for disease treatment hot topic both preclinical studies clinical trials. Developing potent inhibitors downstream IL-1 attracts wide-spectrum attention research pharmaceutical fields. In this minireview, we first updated molecular involved associated signaling pathways. We then reviewed cellular pathways obesity, diabetes, other addition, briefly roles cancer growth relative checkpoint therapy. Finally, trials with treatments targeting its were summarized.
Language: Английский
Citations
0
Published: Feb. 5, 2025
Trastuzumab resistance remains a challenge for HER2 positive breast cancer treatment. Targeting metabolic reprogramming would provide novel insights therapeutic strategies. Here, we integrated metabolomics, transcriptomics and epigenomics data of trastuzumab sensitive primary resistant to identify alterations. Aberrant cysteine metabolism was discovered in at both circulating intracellular levels. The inhibition SLC7A11 starvation could synergize with induce ferroptosis. Mechanistically, increased H3K4me3 decreased DNA methylation enhanced transcription cystine uptake cancer. regulation epigenetic modifications modulated ferroptosis sensitivity. These results revealed an innovative approach overcoming by targeting specific amino acid metabolism.
Language: Английский
Citations
0
Published: Feb. 5, 2025
Trastuzumab resistance remains a challenge for HER2 positive breast cancer treatment. Targeting metabolic reprogramming would provide novel insights therapeutic strategies. Here, we integrated metabolomics, transcriptomics and epigenomics data of trastuzumab sensitive primary resistant to identify alterations. Aberrant cysteine metabolism was discovered in at both circulating intracellular levels. The inhibition SLC7A11 starvation could synergize with induce ferroptosis. Mechanistically, increased H3K4me3 decreased DNA methylation enhanced transcription cystine uptake cancer. regulation epigenetic modifications modulated ferroptosis sensitivity. These results revealed an innovative approach overcoming by targeting specific amino acid metabolism.
Language: Английский
Citations
0