Metabolic Reprogramming of Tumor Microenviroment by Engineered Bacteria DOI
Heng Wang, Fang Xu, Chao Wang

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Activation of pyroptosis and immunogenic cell death by targeted liposomal cisplatin for enhanced chemo-immunotherapy for osteosarcoma DOI

Jingyou Bi,

Yuchen Han,

Xin-Li Han

et al.

Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102717 - 102717

Published: March 19, 2025

Language: Английский

Citations

0
CTHRC1: a key player in colorectal cancer progression and immune evasion DOI Creative Commons

Qingjie Chen,

Haohao Wang, Qinghua Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 25, 2025

The multifunctional secreted protein, collagen triple helix repeat containing 1 (CTHRC1), has recently emerged as a significant focus within oncology research. CTHRC1 expression in tumors is governed by complex interplay of regulatory signals, including methylation, glycosylation, and notably, non-coding RNAs, which constitute its predominant mechanism. Colorectal cancer (CRC), highly prevalent epithelial malignancy, sees influencing tumor progression metastasis through modulation several downstream signaling cascades, such Wnt/PCP, TGF-β/Smad, MEK/ERK pathways. Furthermore, contributes to immune evasion CRC via diverse mechanisms. It intricately associated with macrophage phenotypic switching the microenvironment (TME), favoring M2 polarization facilitating infiltration T cells neutrophils. also instrumental escape driving remodeling extracellular matrix interactions cancer-associated fibroblasts. Additionally, CTHRC1’s roles extend regulation hypoxia-related pathways, metabolism glycolysis fatty acids, involvement angiogenesis, all support evasion. Considering multifaceted activities, emerges promising therapeutic target CRC, potential enhance outcomes existing radiotherapeutic immunotherapeutic regimens. This review endeavors delineate mechanistic landscapes CRC. Through comprehensive discussion functions, we aim provide insights that could pave way for innovative approaches therapy.

Language: Английский

Citations

0
Type III interferon primes pDCs for TLR7 activation and antagonizes immune suppression mediated by TGF-β and PGE2 DOI Creative Commons
Candice Sakref,

Alexis Saby,

Céline Rodriguez

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 28, 2025

Conventional dendritic cell and plasmacytoid (pDC) subsets have specialized functions that can be modulated by the tumor microenvironment, produce different interferons are central to antitumor immune responses. While function of type I in immunity is well characterized, III produced 1 conventional cells microenvironment remains unclear. Here we demonstrate vitro orchestrate pDC survival, activation TLR7 expression blood, thereby enhancing responses a ligand. Moreover, show tumor-associated pDCs express highest level IFNLR1, these most responsive IFN-III. Importantly, prevent inhibition induced TGF-β or PGE2 soluble milieu from patients restores production IFN-α pDCs. With having pleotropic regulation, our results thus implicate IFN-III-mediated modulation broad impact on various pathological situations.

Language: Английский

Citations

0
Therapeutically targeting endometrial cancer in preclinical models by ICAM1 antibody-drug conjugates DOI

Hanfei Xie,

Lu Sun,

Shili Yao

et al.

Gynecologic Oncology, Journal Year: 2025, Volume and Issue: 196, P. 16 - 27

Published: March 28, 2025

Language: Английский

Citations

0
Metabolic Reprogramming of Tumor Microenviroment by Engineered Bacteria DOI
Heng Wang, Fang Xu, Chao Wang

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0