Vermutete Histaminintoleranz – Wie vorgehen?

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Der "Histaminintoleranz" liegt häufig eine Selbstdiagnose zugrunde. Aufgrund der bekannten Bandbreite an Reaktionen, die durch endogen produziertes, gespeichertes und freigesetztes Histamin als Botenstoff vermittelt werden kann, wird postuliert, dass Nahrungshistamin Auslöser für entsprechende Reaktionen sein könne. Ergebnisse von Untersuchungen mit doppelblinden, placebokontrollierten Provokationstests bestätigen das nicht, sondern zeigen vielmehr, oral verabreichtes keine reproduzierbaren auslöst andererseits nach Placebo auftreten, was auf einen starken Noceboeffekt hinweist. Ohne Reproduzierbarkeit ist Definition einer Unverträglichkeit allerdings nicht erfüllt. Da viele Betroffene stark unter ihrer leiden, weil Speiseauswahl Lebensqualität soziales Miteinander massiv einschränkt, haben deutschsprachigen allergologischen Fachgesellschaften Leitlinie herausgegeben, ein pragmatisches diagnostisches therapeutisches Vorgehen beschreibt. Dabei geht es vorrangig darum, über Optimierung Verdauungsvoraussetzungen Symptome zu lindern erweitern, weniger um Entkräftigung Verdachtsdiagnose. Die Zusammenarbeit allergologisch versierten Ernährungsfachkraft daher dringend anzuraten.

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The Role of Ultra-Processed Foods in Inflammation and Aging

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Processed foods are that undergo physical, chemical, or biological processes to enhance durability, extend shelf life, improve taste and texture, alter nutritional content, facilitate consumption. While traditional processed preserved packaged through methods such as canning salting, ultra-processed (UPFs) industrially produced formulations ready-to-eat ready-to-heat typically contain little no whole food ingredients. Recent evidence suggests the adverse health effects of UPFs may not only be due nutrients they provide but also non-nutritive components their impact on gut health. Diets rich in associated with cellular changes leading oxidative stress, which turn contributes inflammation aging processes. In this context, reducing consumption UPFs, limiting refined carbohydrates, modifying meal timing frequency recommended for improving

Language: Английский

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Ultra-processed food consumption affects structural integrity of feeding-related brain regions independent of and via adiposity

npj Metabolic Health and Disease, Journal Year: 2025, Volume and Issue: 3(1)

Published: April 8, 2025

Consumption of ultra-processed foods (UPFs) increases overall caloric intake and is associated with obesity, cardiovascular disease, brain pathology. There scant evidence as to why UPF consumption leads increased whether the negative health consequences are due adiposity or characteristics UPFs. Using UK Biobank sample, we probed associations between consumption, adiposity, metabolism, structure. Our analysis reveals that high linked adverse metabolic profiles, alongside cellularity changes in feeding-related subcortical areas. These partially mediated by dyslipidemia, systemic inflammation body mass index, suggesting UPFs exert effects on beyond just contributing obesity. This dysregulation network structures may create a self-reinforcing cycle consumption.

Language: Английский

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Associations between phthalate metabolites and two novel systemic inflammatory indexes: a cross-sectional analysis of NHANES data

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: April 24, 2025

The potentially risky effects of metabolites phthalates (mPAEs) on inflammation and immune function have attracted much attention in recent years. However, direct studies the relationship between these systemic inflammatory index (SII) response (SIRI) are limited. This cross-sectional study used generalized linear regression models (GLM), restricted cubic splines (RCS), weighted quantile sum (WQS), Bayesian kernel-machine (BKMR) to analyze data from 2,763 U.S. adults aged 20 80 years, obtained National Health Nutrition Examination Survey (NHANES) conducted 2013 2018. aimed investigate urine samples nine mPAEs levels SII/SIRI a single, nonlinear, mixed explored robustness findings under single using two sensitivity analyses for completeness. In addition, six variables (age, sex, BMI, percentage total daily energy intake ultra-processed foods (UPFs), vegetable intake, dietary supplements) association results were through subgroup identify important confounders. exposure analyses, mono-n-butyl phthalate (MnBP), mono-ethyl (MEP), monobenzyl (MBzP) positively associated with SII/SIRI. demonstrated positive collective concentrations SII/SIRI, MBzP being identified as significant contributor urinary mPAEs. analysis exposures show that is more females, overweight/obese populations, young/middle-aged populations high UPFs. Positive associations was determined most impact. significantly influenced by female groups, young middle-aged overweight obese individuals, well those higher

Language: Английский

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Prehabilitation in surgery – an update with a focus on nutrition

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Purpose of the review Since introduction prehabilitation concept for optimizing functional capacity before surgery 20 years ago, evidence and interest has grown considerably. This summarizes recent proposes questions with special regard to nutritional component. Recent findings Several meta-analyses multimodal (exercise, nutrition, psychological support) have been published recently. These reviews suggest that preoperative conditioning can improve reduce complication rate many patient groups (risk bias: moderate low). A prerequisite is identification high-risk patients using suitable screening assessment tools. Additionally, there are currently no standardized, clear recommendations organization implementation programs. The programs vary greatly in duration, content, outcome measurement. Although nutrition interventions enhanced outcomes consistently, was which intervention should be applied whom over consistent time frame four six weeks (timeframe most programs). Summary To advance our understanding work best, how they work, additional low risk bias adequately powered trials required. Nevertheless, presents offered major on a risk-stratified basis.

Language: Английский

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Association of ultra-processed foods with phenotypic age acceleration in US adults: a mediation analysis of body mass index in the NHANES

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 24, 2025

Background The rising intake of ultra-processed foods (UPFs) has been linked to adverse health outcomes, yet its impact on aging acceleration remains unclear. Objective This study aimed examine the association between percentage total daily calories (%Kcal) and grams (%Gram) from UPFs phenotypic age (PhenoAgeAccel). Methods Data 12,079 adults in NHANES 2005–2010 cycles were analyzed. relationship PhenoAgeAccel was assessed using multivariable linear regression restricted cubic splines, with adjustments for relevant covariates. mediating role body mass index (BMI) also explored. Results A significant positive observed PhenoAgeAccel, highest quartile showing an increase 0.60 (95% CI: 0.15, 1.05; p trend = 0.039), but no found PhenoAgeAccel. Mediation analysis indicated that BMI mediated 27.5% Sensitivity analyses confirmed robustness results. Conclusion Higher is positively associated playing a role.

Language: Английский

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Ultra-Processed Food Consumption and Cardiometabolic Risk Factors in Children Living in Northeastern Brazil

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3944 - 3944

Published: Nov. 19, 2024

To analyze the association between ultra-processed food (UPF) consumption and cardiometabolic, biochemical, inflammatory risk factors in children a metropolis Northeast Brazil.

Language: Английский

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Ultra-Processed Foods and the Impact on Cardiometabolic Health: The Role of Diet Quality

Diabetes & Metabolism Journal, Journal Year: 2024, Volume and Issue: 48(6), P. 1047 - 1055

Published: Nov. 22, 2024

The consumption of ultra-processed foods (UPFs) has surged globally, raising significant public health concerns due to their associations with a range adverse outcomes. This review aims elucidate potential impacts UPF intake and underscore the importance considering diet quality when interpreting study findings. group, as classified by Nova system based on extent industrial processing, contains numerous individual food items wide spectrum nutrient profiles, well differential reflected effects. given may misalign processing levels so that can be nutritious healthful whereas non-UPF low excess which lead consequences. current argues it is critical focus nutritional content role within overall dietary pattern rather than only level processing. Further research should dissect effects investigate ingredients render categorization, understand roles metabolomics gut microbiome in mediating modulating consider environmental sustainability studies. Emphasizing nutrient-dense patterns shall remain pivotal strategy for promoting preventing chronic diseases.

Language: Английский

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The effects of food-based versus supplement-based very low-energy diets on gut microbiome composition and health outcomes in women with high body mass index (The MicroFit Study): a randomised controlled trial

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 12, 2024

Abstract Objective To compare the effects of consuming food-based versus supplement-based very low-energy diet (VLED) programs on gut microbiome composition in women with a high body mass index (BMI). Design An investigator-initiated, single-blind, two-arm, parallel-group randomised controlled-feeding trial computer-generated 1:1 randomisation. From May 2021 to February 2022, aged 30– 65 years BMI 30–45 kg/m 2 were recruited from southwest Victoria, Australia, and three-week or VLED program. The primary outcome was between-group differential change faecal alpha diversity (Shannon index) baseline week three, assessed using shotgun metagenomics. Outcome assessors, study investigators, analysing statisticians blinded group allocation until analysis completion. Allocation concealment managed by an independent researcher computer software system. Modified intention-to-treat (mITT) analyses linear mixed-effects regression models estimated mean changes, reported as beta-coefficient point estimates (β) 95% confidence intervals (95%CI), adjusted for multiple comparisons. Results Forty-seven participants (food-based: n=23, supplement-based: n=24). Of 45 analysed, there Shannon (mITT β: 0.37, 95%CI: 0.15 0.60) greater increase (mean change: 0.26, 0.09 0.44; n=23) −0.10, −0.25 0.05; n=22). There 27 non-serious adverse events 8, 19), all non-serious. Conclusion A VLED, more whole food components fewer highly processed industrial ingredients, increases than VLED. Summary Box What is already known this topic Dietary interventions can alter composition, but impact processing, including nutritionally balanced low energy diets (VLEDs), less understood. adds This shows that How might affect research, practice, policy. Summarise implications Our findings underscore need further research into how specific attributes diets, both beyond nutritional influence microbiome.

Language: Английский

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