IL-1β+ macrophages and the control of pathogenic inflammation in cancer

Trends in Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Blocking S100A9-signaling is detrimental to the initiation of anti-tumor immunity

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 21, 2024

S100A9, a multifunctional protein mainly expressed by neutrophils and monocytes, poses an immunological paradox. In virus infections or sterile inflammation, it functions as alarmin attracting innate immune cells, well mediating proinflammatory effects through TLR4 signaling. However, in cancer, S100A9 levels have been shown to associate with poor prognosis lack of response immunotherapy. Its expression myeloid cells has related suppressive phenotype, the so-called derived suppressor (MDSCs). Targeting cancer therefore proposed potential way relieve myeloid-mediated suppression. Surprisingly, we found that blocking extracellular signaling from using inhibitor Paquinimod, resulted increased tumor growth detrimental effect on anti-PD-L1 efficacy CT26 model. This was caused reduction infiltration about half untreated controls, made up 5-fold decrease Ly6C high monocytic cells. The Ly6G + compartment not reduced Paquinimod treatment, suggesting alternative mechanisms which contributes Intratumoral injection recombinant early after mice inoculation had anti-tumor effect. These findings indicate important yet understudied role stimulatory signal settings, highlight exploit such signals promote beneficial responses.

Language: Английский

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The Intersection of Trauma and Immunity: Immune Dysfunction Following Hemorrhage

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2889 - 2889

Published: Dec. 19, 2024

Hemorrhagic shock is caused by rapid loss of a significant blood volume, which leads to insufficient flow and oxygen delivery organs tissues, resulting in severe physiological derangements, organ failure, death. Physiologic derangements after hemorrhage are due large part the body’s strong inflammatory response, immune dysfunction, secondary complications such as chronic immunosuppression, increased susceptibility infection, coagulopathy, multiple unregulated inflammation. Immediate management hemorrhagic includes timely control source bleeding, restoring intravascular preferably with whole blood, prevention ischemia failure optimizing tissue oxygenation. However, currently, there no clinically effective treatments available that can stabilize response reinstate homeostatic conditions. In this review, we will discuss what known about immunologic dysfunction following potential therapeutic strategies.

Language: Английский

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Preeclampsia-specific immune cell network in placenta revealed by Cytometry by time of flight and single-cell RNA-seq

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 8, 2024

Abstract Preeclampsia (PE), a major cause of maternal and perinatal mortality with highly heterogeneous causes symptoms, is usually complicated by gestational diabetes mellitus (GDM). However, comprehensive understanding the immune microenvironment in placenta PE differences between GDM still lacking. In this study, Cytometry time flight (CyTOF) indicated that frequencies memory-like Th17 cells (CD45RA - CCR7 + IL-17A CD4 ), CD8 T (CD38 CXCR3 Helios CD127 ) pro-inflam Macs (CD206 CD163 CD38 mid CD107a low CD86 HLA-DR CD14 were increased, while anti-inflam CD33 granulocyte myeloid-derived suppressor (gMDSCs, CD11b CD15 hi decreased compared NP, but not or GDM&PE. The positively correlated negatively gMDSCs. Single-cell RNA sequencing revealed transferring F4/80 CD206 Folr2 Ccl7 Ccl8 C1qa C1qb C1qc phenotype from uterus mice to normal pregnant induced production IL-17a Rora Il1r1 TNF Cxcr6 S100a4 CD44 via IGF1-IGF1R, which contributed development recurrence PE. Pro-inflam also inhibited Ly6g S100a8 S100a9 Retnlg Wfdc21 gMDSCs at maternal-fetal interface, leading PE-like symptoms mice. conclusion, study PE-specific cell network, was regulated Macs, providing new ideas about pathogenesis

Language: Английский

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Preeclampsia-specific immune cell network in placenta revealed by Cytometry by time of flight and single-cell RNA-seq

eLife, Journal Year: 2024, Volume and Issue: 13

Published: Sept. 11, 2024

Preeclampsia (PE), a major cause of maternal and perinatal mortality with highly heterogeneous causes symptoms, is usually complicated by gestational diabetes mellitus (GDM). However, comprehensive understanding the immune microenvironment in placenta PE differences between GDM still lacking. In this study, cytometry time flight indicated that frequencies memory-like Th17 cells (CD45RA − CCR7 + IL-17A CD4 ), CD8 T (CD38 CXCR3 Helios CD127 ) pro-inflam Macs (CD206 CD163 CD38 mid CD107a low CD86 HLA-DR CD14 were increased, while anti-inflam CD33 granulocyte myeloid-derived suppressor (gMDSCs, CD11b CD15 hi decreased compared normal pregnancy (NP), but not or GDM&PE. The positively correlated negatively gMDSCs. Single-cell RNA sequencing revealed transferring F4/80 CD206 Folr2 Ccl7 Ccl8 C1qa C1qb C1qc phenotype from uterus mice to pregnant induced production IL-17a Rora Il1r1 TNF Cxcr6 S100a4 CD44 via IGF1–IGF1R, which contributed development recurrence PE. Pro-inflam also inhibited Ly6g S100a8 S100a9 Retnlg Wfdc21 gMDSCs at maternal–fetal interface, leading PE-like symptoms mice. conclusion, study PE-specific cell network, was regulated Macs, providing new ideas about pathogenesis

Language: Английский

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The myelopoiesis in cancer

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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