Coordinated changes in thymic stromal and hematopoietic cells that define the perinatal to juvenile transition

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

SUMMARY T cells in the perinatal thymus have distinct phenotypes and functions that may be instructed by age-specific features of microenvironment. We evaluated molecular cellular profiles thymic stromal cells, including epithelial (TECs), mesenchyme, endothelium, hematopoietic antigen presenting (hAPCs), from birth through one-month age mice. Single-cell transcriptional profiling, flow cytometry, immunohistochemistry revealed coordinated changes accompanied altered thymocyte differentiation at defined transitional ages during shift growth to juvenile homeostasis, which was mirrored humans. These analyses link diminished IGF2 expression mesenchymal with activation RB pathway TECs transition. Moreover, a increase type I interferon signaling stroma across transition is associated processing presentation signatures hAPCs. Collectively, these datasets provide resource interrogate

Language: Английский

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Sterile production of interferons in the thymus

The Journal of Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract T-cell central tolerance is controlled by thymocyte TCR recognition of self-peptides presented thymic APCs. While epithelial cells are essential for tolerance, a variety other traditional APCs also play critical roles in selection. Similar to how peripheral require activation become effective, tolerogenic. Recent studies have identified IFNs as an factor the and generation optimally tolerogenic environment. In this review, we focus on interferon (IFN) production within thymus its effects developing thymocytes. We examine importance IFN itself well interferon-stimulated proteins generated during immune responses.

Language: Английский

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Thymic physiology and pathophysiology in Myasthenia Gravis

International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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