Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 16, 2024
Language: Английский
Trends in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
5
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 484 - 484
Published: Jan. 8, 2025
Alzheimer's disease (AD) remains a leading cause of cognitive decline and mortality worldwide, characterized by neurodegeneration, synaptic deficiencies, neuroinflammation. Despite advancements in early detection, diagnosis, treatment, AD presents substantial challenges due to its complex pathology, heterogeneity, the limited efficacy current therapies. Consequently, there is pressing need for novel therapeutic agents target multifaceted aspects enhance treatments, minimize adverse effects. AdipoRon, an adiponectin receptor agonist, has garnered interest potential neuroprotective effects, including reducing neuroinflammation, improving mitochondrial function, mitigating tau hyperphosphorylation. This review aimed evaluate effects AdipoRon-based replacement therapy against AD, using comprehensive approach grounded PICO framework-Population, Intervention, Comparison, Outcomes. A total six studies were reviewed, vitro vivo investigations examining AdipoRon's impact on various models. These involved different cell lines transgenic mouse models, assessing outcomes such as phosphorylation, relevant molecular pathways. By synthesizing data from these studies, our thoroughly explains mechanisms action, agent AD. analysis aims highlight state knowledge, identify gaps research, suggest directions future clinical applications.
Language: Английский
Citations
2
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 14, 2025
The potential of utilizing the Triglyceride Glucose Index (TyG), along with its combination obesity indicators, for predicting risk coronary heart disease (CHD) in middle-aged and elderly population remains uncertain. This research aims to conduct a cohort study assess predictive capacity TyG indicators forecasting 10-year incidence new-onset CHD among Luzhou region. was derived from China Cardiometabolic Disease Cancer Cohort (4C) Study, comprising 8647 ordinary residents meeting specific criteria. subjects were grouped based on quartiles TyG, TyG-WC, TyG-WtHR, TyG-BMI, TyG-WHR, occurrence observed over period. comprised participants, 484 developing CHD, resulting an rate 5.5% overall follow-up population. comparison across different revealed statistically significant difference (P < 0.001), order being 4th quartile > 3rd 2nd 1st quartile. Cox proportional hazards regression analysis results indicated that, after adjusting multiple influencing factors, gradually increased 5 indicators. Specifically, when according TyG-WC quartiles, 0.05) between compared ROC curve demonstrate that (area under 0.608, P 0.001) TyG-WtHR exhibit superior value 0.568, TyG-BMI 0.576, TyG-WHR 0.595, 0.001). 1. varying degrees correlation 2. may serve as factor
Language: Английский
Citations
1
Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Neutrophils, as essential component of the innate immune response, form a crucial part in defence mechanisms through release extracellular traps (NETs). These web-like structures, composed chromatin and antimicrobial proteins, are for entrapment inactivation pathogens. However, either constitutive formation or inefficient clearance NETs leads to adverse effects such fibrosis, thrombosis, delayed wound healing tissue damage multiple diseases associated with sterile inflammation. This dichotomy casts both protective agents harmful factors several autoimmune diseases, metabolic syndromes, systemic infections, malignancies. Besides microbes their products, variety stimulants including pro-inflammatory cytokines induce NETs. The complex interactions cross talk among IL-8, IL-6, GM-CSF, TNF-α, IFNs, IL-1β activate neutrophils also contributes vicious circle inflammatory cascade, leading increased inflammation, oxidative stress, thrombotic events. Emerging evidence indicates that dysregulated cytokine milieus diabetes mellitus, obesity, atherosclerosis, stroke, rheumatoid arthritis, lupus erythematosus, potentiate release, thereby promoting disease development. Thus, represent critical effectors potential therapeutic targets, underscoring importance context cytokine-mediated therapies spectrum diseases. In present review, we describe various signalling pathways activating different human pathologies. Further, review identifies strategies pharmacologically modulate reduce
Language: Английский
Citations
6
Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 273 - 273
Published: Jan. 23, 2025
Background/Objectives: Crohn's disease (CD), a chronic inflammatory gastrointestinal illness, is the result of genetics and environmental factors. Adipose tissue has recently been found to play significant role in CD. Methods: here, we examined relationship between adiponectin, HMW oligomers, CD 92 patients. Results: first, verified that patients' therapies had no influence on nutritional biochemical variables. Correlation analysis adiponectin parameters relationship; therefore, investigated its with severity markers. Based divided patients into tertiles CDAI was lowest second third tertile [I: <19.3 (n = 31); II: 19.3-22.2 III: >22.2 30)]. Furthermore, IL-6 CRP were higher tertile, while lymphocytes lower tertile. showed both oligomers inversely related directly CRP. A ROC curve evidenced carrying values ≤ 19 performed well predicting worse lymphocyte (AUCs: 0.826 0.806). Next, based finding highest Lymphocytes substantially higher. Conclusions: altogether, these data suggest biological for status. However, molecular effects remain unclear further studies are needed clarify applicability as biomarker.
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 149, P. 114273 - 114273
Published: Feb. 10, 2025
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 22, 2025
Abstract Obesity is a prevalent health issue among adolescents, characterized by chronic low-grade inflammation, which increases the risk of developing various diseases in future. The systemic immune-inflammation index (SII) serves as an indicator inflammation and immune response. This study conducted cross-sectional analysis using data from National Health Nutrition Examination Survey (NHANES) 2007 to 2016, including 5,676 participants. A multivariate logistic regression model, Generalized Additive Models (GAM), subgroup were used examine relationship between obesity SII. results revealed significant positive correlation log SII adolescent (1.254 [1.024–1.537]). Furthermore, increased with higher quartiles Subgroup interaction tests showed that this association persisted across factors, female gender, race (Non-Hispanic White Mexican American), non-hyperlipidemia, normal white blood cell count, PIR < 1. Additionally, U-shaped was observed, turning point at 6.410. findings suggest increase significantly associated adolescents. However, further validation through large-scale prospective studies needed.
Language: Английский
Citations
0
Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)
Published: March 8, 2025
Obesity and abnormal lipid metabolism increase the risk of various cardiometabolic diseases, including diabetes, heart disease, stroke. However, impact abdominal obesity (AO) non-traditional parameters on multimorbidity (CMM) remains unclear. This study aims to investigate separate combined effects AO incidence CMM. enrolled 7,597 eligible participants from China health retirement longitudinal (CHARLS). Cox proportional hazards models were used perform adjusted regression analyses mediation analyses, with Kaplan-Meier analysis for cumulative hazards. Restricted cubic splines utilized evaluate nonlinear relationship between CMM among AO. Subgroup conducted stratification by age, gender, BMI, smoking status, drinking hypertension interaction across different populations. Additionally, sensitivity further performed subgroups During 7-year follow-up period, a total 699 (9.20%) newly diagnosed curves revealed that subgroup both high levels had highest hazard developing In fully model, exhibited confirmed robustness these findings, showing consistent results demographic groups under analytical conditions. Furthermore, was found significantly mediated associations The associated Notably, may induce partially mediating serum lipids in human metabolism. findings highlighted importance joint evaluation primary prevention
Language: Английский
Citations
0
Endocrines, Journal Year: 2025, Volume and Issue: 6(1), P. 13 - 13
Published: March 11, 2025
Introduction: Early-life neurological and inflammatory disorders significantly affect long-term cognitive, social, emotional development. The ‘Developmental Origins of Health Disease’ hypothesis states that an adverse intrauterine environment may predispose offspring to chronic health conditions due altered growth Factors measured in umbilical cord blood can provide information about the status utero during Evidence indicates adipokines, namely leptin adiponectin, influence fetal programming could be useful predicting outcomes. Leptin adiponectin are crucial energy homeostasis, immune response, placental function, some studies suggest concentrations increase risk developing later life. Further, limited have demonstrated sex-specific differences adipokine disease risk. Conclusions: Understanding role adipokines offer new insights into early prediction intervention strategies, promoting better outcomes for children at diseases maternal pregnancy.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 14, 2025
Peripheral arterial disease (PAD) is a common complication associated with diabetes, which can lead to foot ischemia. The condition often accompanied by infection and necrosis, ultimately leading diabetic ulcers the risk of amputation. Brown adipose tissue (BAT) its secreted cytokines play an essential role in regulation glucose homeostasis, modulation inflammatory responses, vascular endothelial cell proliferation. transplantation BAT into ischemic regions may offer therapeutic benefits alleviating symptoms PAD. A mouse model was established via intraperitoneal administration streptozocin. Subsequently, lower limb ulcer constructed transection femoral artery ligation vein. harvested from subscapular region employed as graft. research utilized Laser Doppler monitoring, Western blot analysis, hematoxylin-eosin (HE) staining, immunofluorescence enzyme-linked immunosorbent assay (ELISA) evaluate blood flow recovery regions, histopathological changes, angiogenesis remodeling, M1/M2 macrophage polarization. significantly enhanced mice while concurrently reducing necrotic tissue. Pathological analyses demonstrate that mitigates damage, stimulates angiogenesis, supports remodeling. Furthermore, blotting, immunofluorescence, ELISA results revealed reduces levels tissues, increases expression angiogenic factors, promotes polarization macrophages M1 M2 phenotype. has demonstrated mitigate injury mice, attenuate facilitate restoration flow. These effects be linked alterations
Language: Английский
Citations
0