In Situ Vaccination Via Hypochlorous Acid-Activatable Nanoassemblies for Synergistic Cancer Immunotherapy

Published: Jan. 1, 2025

Language: Английский

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Evaluation and In Situ Library Expansion of Small Molecule MHC-I Inducers

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

ABSTRACT Immunotherapy has emerged as a powerful strategy for combating cancer by harnessing the patient immune system to recognize and eliminate malignant cells. The major histocompatibility complex class I (MHC-I) pivotal role in recognition step. These surface proteins present cancer-specific neoantigens CD8+ T cells, which triggers activation cell-mediated killing. However, cells can often evade detection downregulating MHC-I expression, renders response less effective. In turn, this resistance mechanism offers an opportunity bolster expression via therapeutic interventions. Here, we conducted initial comprehensive evaluation of previously purported small molecule inducers identified heat shock protein 90 (Hsp90) inhibitors privileged expression. With core scaffold hand, employed situ click chemistry-based derivatization generate 380 novel compounds same family. New agents from library showed high levels induction, with one triazole-based analogs, CliMB-325 , also enhancing cell exhibiting lower toxicity, could potentiate some immunotherapeutic modalities. Moreover, demonstrated potential diversification discovery molecules counter evasion.

Language: Английский

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The Dynamic Role of Ferroptosis in Cancer Immunoediting: Implications for Immunotherapy

Pharmacological Research, Journal Year: 2025, Volume and Issue: 214, P. 107674 - 107674

Published: Feb. 27, 2025

Currently, cancer immunotherapy strategies are primarily formulated based on the patient's present condition, representing a "static" treatment approach. However, progression is inherently "dynamic," as immune environment not fixed but undergoes continuous changes. This dynamism characterized by ongoing interactions between tumor cells and cells, which ultimately lead to alterations in microenvironment. process can be effectively elucidated concept of immunoediting, divides development into three phases: "elimination," "equilibrium," "escape." Consequently, adjusting regimens these distinct phases may enhance patient survival improve prognosis. Targeting ferroptosis an emerging area immunotherapy, our findings reveal that antioxidant systems associated with possess dual roles, functioning differently across immunoediting. Therefore, this review delve role system progression. It also propose targeting at different stages, aiming illuminate significant implications various for immunotherapy.

Language: Английский

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Peto’s paradox: 2 problems 2 answers

Frontiers in Ecology and Evolution, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 26, 2025

Peto’s paradox throws down the gauntlet to researchers explain why larger animals have same cancer risk as more diminutive species, notwithstanding much higher cellularity of former. Any explanation must also contend with fact that a greater longevity and thus longer for their number cells undergo mutagenesis. The Paradox comprises two questions. first is exhibit tumor smaller animals. second those do not than ephemeral species. has appeared so elusive it been often assumed any single account both phenomena simultaneously. In reality problems distinct solutions.

Language: Английский

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T cell exhaustion: early or late in tumour progression?

Nature reviews. Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

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Positive sentinel lymph node biopsy on promotion of metastasis: An unexpected effect?

Medical Hypotheses, Journal Year: 2025, Volume and Issue: unknown, P. 111624 - 111624

Published: April 1, 2025

Language: Английский

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Molecular Strategies for Constructing Epoxy‐Type Afterglow Probes in Disease Diagnosis and Treatment

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract Epoxy‐type afterglow luminescence is a cascade reaction of photochemical defects caused as result the formation and release epoxy intermediates, exhibiting continuous phenomenon that remains intrinsic after excitation, with extremely impressive signal‐to‐background ratio (SBR) level in vivo. Afterglow based on this epoxy‐type mechanism ideally suited for applications developments diagnosis treatment biological diseases. In tutorial review, work aims to deeply elaborate mechanisms materials present application imaging Lastly, future perspectives potential challenges technology preclinical diagnostic, therapeutic, predictive analyses, well clinical translations are discussed.

Language: Английский

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