Context dependence in assembly code for supramolecular peptide materials and systems

Nature Reviews Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Language: Английский

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Self-Assembly of Polymers and Their Applications in the Fields of Biomedicine and Materials

Polymers, Journal Year: 2024, Volume and Issue: 16(15), P. 2097 - 2097

Published: July 23, 2024

Polymer self-assembly can prepare various shapes and sizes of pores, making it widely used. The complexity diversity biomolecules make them a unique class building blocks for precise assembly. They are particularly suitable the new generation biomaterials integrated with life systems as they possess inherent characteristics such accurate identification, self-organization, adaptability. Therefore, many excellent methods developed have led to practical results. At same time, development advanced science technology has also expanded application scope synthetic polymers. By utilizing this technology, materials properties be prepared applied in field tissue engineering. Nanomaterials transparent conductive fields electronic displays smart glass. Multi-dimensional, controllable, multi-level between nanostructures been achieved through quantitative control polymer dosage combination, chemical modification, composite methods. Here, we list classic applications natural- artificially synthesized biomedicine materials, introduce cutting-edge technologies involved these applications, discuss in-depth advantages, disadvantages, future directions each type self-assembly.

Language: Английский

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Rapid, efficient and highly selective separation and enrichment of glycoprotein by surface-imprinted MOF nanoparticles loaded with high-density boric acid

Separation and Purification Technology, Journal Year: 2024, Volume and Issue: 354, P. 128911 - 128911

Published: July 24, 2024

Language: Английский

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A glycan foldamer that uses carbohydrate–aromatic interactions to perform catalysis

Nature Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Language: Английский

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Direct Imaging of Chirality Transfer Induced by Glycosidic Bond Stereochemistry in Carbohydrate Self-Assemblies

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Carbohydrates, essential biological building blocks, exhibit functional mechanisms tied to their intricate stereochemistry. Subtle stereochemical differences, such as those between the anomers maltose and cellobiose, lead distinct properties due differing glycosidic bonds; former is digestible by humans, while latter not. This underscores importance of precise structural determination individual carbohydrate molecules for deeper insights. However, complexity conformational flexibility, combined with high spatial resolution needed, have hindered direct imaging Here, we employ noncontact atomic force microscopy integrated a data-efficient, multifidelity structure search approach accelerated machine learning integration determine 3D coordinates two on Au(111). We observe that stereochemistry bond regulates on-surface chiral selection in self-assemblies. The reconstructed models, validated against experimental data, provide reliable atomic-scale evidence, uncovering origin chirality from anomerism. Our study confirms nc-AFM technique real-space discrimination at single-molecule level, providing pathway bottom-up investigations into structure-property relationships carbohydrates research materials science.

Language: Английский

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Controlling Glycan Folding with Ionic Functional Groups

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Glycans are intrinsically flexible molecules that can adopt many conformations. These often carry ionic functional groups influence glycan's conformational preferences, dynamics, and aggregation tendencies. Inspired by these mechanisms, we have engineered a glycan sequence whose secondary structure be precisely manipulated using groups. We strategically incorporated substituents into adopting hairpin conformation. Complementary stabilized the closed conformers, while repulsions shifted populations toward open forms. External stimuli, such as pH variations or enzyme addition, enabled us to dynamically control hairpin's opening closing. Additionally, changes in protonation states led aggregation, suggesting opportunities for creation of responsive glycan-based materials.

Language: Английский

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Light-responsive glycosidase inhibitors: Tuning enzyme selectivity and switching factors through integrated chemical and optoglycomic strategies

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108575 - 108575

Published: May 1, 2025

Language: Английский

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An integrated platform for decoding hydrophilic peptide fingerprints of hepatocellular carcinoma using artificial intelligence and two-dimensional nanosheets

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(31), P. 7532 - 7542

Published: Jan. 1, 2024

Hydrophilic peptides (HPs) play a critical role in the pathogenesis of hepatocellular carcinoma (HCC). However, comprehensive and in-depth high-throughput analysis specific changes HPs associated with HCC remains unrealized, due to complex nature biological fluids challenges mining patterns large data sets. The clinical diagnosis still lacks non-destructive accurate classification method, given limited specificity widely used biomarkers. To address these challenges, we have established multifunctional platform that integrates artificial intelligence computation, hydrophilic interaction extraction HPs, MALDI-MS testing. This aims achieve highly sensitive HP fingerprinting for HCC. method not only facilitates efficient detection but also achieves remarkable 100.00% diagnostic accuracy test cohort, supported by machine learning algorithms. By constructing panel 10 characteristic features, achieved 98% cohort rapid identified 62 deeply involved pathways related liver diseases. integrated strategy provides new research directions future biomarker studies as well early individualized treatment

Language: Английский

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High-sensitivity detection of glycoproteins by high-density boric acid modified metal–organic framework surface molecularly imprinted polymers resonant light scattering sensor

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 322, P. 124813 - 124813

Published: July 14, 2024

Language: Английский

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Atomically resolved imaging of the conformations and adsorption geometries of individual β-cyclodextrins with non-contact AFM

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 2, 2024

Glycans, consisting of covalently linked sugar units, are a major class biopolymers essential to all known living organisms. To better understand their biological functions and further applications in fields from biomedicine materials science, detailed knowledge structure is essential. However, due the extraordinary complexity conformational flexibility glycans, state-of-the-art glycan analysis methods often fail provide structural information with atomic precision. Here, we combine electrospray deposition ultra-high vacuum non-contact force microscopy theoretical calculations unravel β-cyclodextrin, cyclic glucose oligomer, atomic-scale detail. Our results, established on single-molecule level, reveal different adsorption geometries conformations β-cyclodextrin. The position individual hydroxy groups location stabilizing intramolecular H-bonds deduced atomically resolved images, enabling unambiguous assignment molecular demonstrating potential method for analysis.

Language: Английский

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