npj Biofilms and Microbiomes,
Journal Year:
2021,
Volume and Issue:
7(1)
Published: Nov. 10, 2021
Abstract
Biofilms
are
organised
heterogeneous
assemblages
of
microbial
cells
that
encased
within
a
self-produced
matrix.
Current
estimates
suggest
up
to
80%
bacterial
and
archaeal
reside
in
biofilms.
Since
biofilms
the
main
mode
life,
understanding
their
biology
functions
is
critical,
especially
as
controlling
biofilm
growth
essential
industrial,
infrastructure
medical
contexts.
Here
we
discuss
both
collections
individual
cells,
multicellular
biological
individuals,
introduce
concept
unique
incubators
diversity
for
world.
Frontiers in Microbiology,
Journal Year:
2020,
Volume and Issue:
11
Published: Oct. 29, 2020
Pathogenic
microorganisms
and
their
chronic
pathogenicity
are
significant
concerns
in
biomedical
research.
Biofilm-linked
persistent
infections
not
easy
to
treat
due
resident
multidrug-resistant
microbes.
Low
efficiency
of
various
treatments
in-vivo
toxicity
available
antibiotics
drives
the
researchers
towards
discovery
many
effective
natural
anti-biofilm
agents.
Natural
extracts,
product-based
agents
more
efficient
than
chemically
synthesized
counterparts
with
lesser
side
effects.
The
present
review
primarily
focuses
on
agents,
i.e.
phytochemicals,
biosurfactants,
antimicrobial
peptides
microbial
enzymes
along
sources,
mechanism
action
via
interfering
quorum-sensing
pathways,
disruption
extracellular
polymeric
substance,
adhesion
inhibitory
concentrations
existing
literature
so
far.
This
study
provides
a
better
understanding
that
particular
molecule
exhibit
different
mode
actions
biofilm
activity
against
one
pathogenic
species.
information
can
be
exploited
further
improve
therapeutic
strategy
by
combination
compounds
from
diverse
sources.
Periodontology 2000,
Journal Year:
2021,
Volume and Issue:
86(1), P. 32 - 56
Published: March 10, 2021
Abstract
The
extracellular
matrix
is
a
critical
component
of
microbial
biofilms,
such
as
dental
plaque,
maintaining
the
spatial
arrangement
cells
and
coordinating
cellular
functions
throughout
structure.
polymeric
substances
that
comprise
include
carbohydrates,
nucleic
acids,
proteins,
lipids,
which
are
frequently
organized
into
macromolecular
complexes
and/or
associated
with
surfaces
within
biofilm.
Cariogenic
plaque
rich
in
glucan
fructan
polysaccharides
derived
from
metabolism
dietary
sucrose.
By
contrast,
subgingival
complex
mixture
macromolecules
still
not
well
understood.
Components
escape
during
lysis
by
active
secretion
or
through
shedding
vesicles
serve
to
anchor
tooth
surface.
biofilm
close
association
host
tissues,
facilitates
interactions
between
microorganisms
host.
outcome
these
may
be
maintenance
health
development
disease,
caries
periodontitis.
affords
protection
against
chemical
physical
insults
hinders
eradication
pathogenic
plaque.
Therefore,
strategies
control
maintain
oral
health.
This
review
discusses
recent
advances
our
understanding
composition,
origins,
function
matrix,
focus
on
New
based
targeting
also
considered.
Nature Microbiology,
Journal Year:
2021,
Volume and Issue:
6(2), P. 151 - 156
Published: Jan. 4, 2021
Abstract
Biofilms
are
microbial
communities
that
represent
a
highly
abundant
form
of
life
on
Earth.
Inside
biofilms,
phenotypic
and
genotypic
variations
occur
in
three-dimensional
space
time;
microscopy
quantitative
image
analysis
therefore
crucial
for
elucidating
their
functions.
Here,
we
present
BiofilmQ—a
comprehensive
cytometry
software
tool
the
automated
high-throughput
quantification,
visualization
numerous
biofilm-internal
whole-biofilm
properties
time.
Antibiotics,
Journal Year:
2023,
Volume and Issue:
12(2), P. 328 - 328
Published: Feb. 4, 2023
Most
bacteria
attach
to
biotic
or
abiotic
surfaces
and
are
embedded
in
a
complex
matrix
which
is
known
as
biofilm.
Biofilm
formation
especially
worrisome
clinical
settings
it
hinders
the
treatment
of
infections
with
antibiotics
due
facilitated
acquisition
antibiotic
resistance
genes
(ARGs).
Environmental
now
considered
pivotal
for
driving
biofilm
formation,
biofilm-mediated
development
dissemination.
Several
studies
have
demonstrated
that
environmental
biofilms
can
be
hotspots
dissemination
ARGs.
These
encoded
on
mobile
genetic
elements
(MGEs)
such
conjugative
mobilizable
plasmids
integrative
(ICEs).
ARGs
rapidly
transferred
through
horizontal
gene
transfer
(HGT)
has
been
shown
occur
more
frequently
than
planktonic
cultures.
models
promising
tools
mimic
natural
study
via
HGT.
This
review
summarizes
state-of-the-art
techniques
visualize
three
main
HGT
mechanisms
biofilms:
transformation,
transduction,
conjugation.
