CeMbio - TheCaenorhabditis elegansMicrobiome Resource

G3 Genes Genomes Genetics, Journal Year: 2020, Volume and Issue: 10(9), P. 3025 - 3039

Published: July 16, 2020

The study of microbiomes by sequencing has revealed a plethora correlations between microbial community composition and various life-history characteristics the corresponding host species. However, inferring causation from correlation is often hampered sheer compositional complexity microbiomes, even in simple organisms. Synthetic communities offer an effective approach to infer cause-effect relationships host-microbiome systems. Yet available suffer several drawbacks, such as artificial (thus non-natural) choice microbes, microbe-host mismatch (

Language: Английский

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A lasting symbiosis: how the Hawaiian bobtail squid finds and keeps its bioluminescent bacterial partner

Nature Reviews Microbiology, Journal Year: 2021, Volume and Issue: 19(10), P. 666 - 679

Published: June 4, 2021

Language: Английский

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Environmental Influences on the Human Microbiome and Implications for Noncommunicable Disease

Annual Review of Public Health, Journal Year: 2021, Volume and Issue: 42(1), P. 277 - 292

Published: April 1, 2021

The human microbiome contributes metabolic functions, protects against pathogens, educates the immune system, and through these basic directly or indirectly, affects most of our physiologic functions. Here, we consider its relationship to several major noncommunicable conditions, including orodigestive tract cancers, neurologic diseases, diabetes, obesity. We also highlight scope contextual macroenvironmental factors (toxicological chemical environment, built socioeconomic environment) individual microenvironmental (smoking, alcohol, diet) that may push microbiota toward less healthy more influencing development diseases. Last, current uncertainties challenges in study environmental influences on implications for understanding disease, suggesting a research agenda strengthen scientific evidence base.

Language: Английский

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The gut microbiome influences host diet selection behavior

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(17)

Published: April 19, 2022

Significance The behavior of diet selection or choice can have wide-reaching implications, scaling from individual animals to ecological and evolutionary processes. Previous work in this area has largely ignored the potential for intestinal microbiota modulate host foraging decisions. notion that gut microbiome may influence been highly speculated years but not yet explicitly tested. Here, we show germ-free mice colonized by differential microbiomes wild rodents with varying natural feeding strategies exhibited significant differences their voluntary dietary selection. Specifically, differed carbohydrate selection, divergent preferences were associated circulating essential amino acids, bacterial tryptophan metabolism, morphology. Together, these results demonstrate a role nutritional physiology behavior.

Language: Английский

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A symbiotic physical niche in Drosophila melanogaster regulates stable association of a multi-species gut microbiota

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 21, 2023

Abstract The gut is continuously invaded by diverse bacteria from the diet and environment, yet microbiome composition relatively stable over time for host species ranging mammals to insects, suggesting host-specific factors may selectively maintain key of bacteria. To investigate specificity, we used gnotobiotic Drosophila , microbial pulse-chase protocols, microscopy stability different strains in fly gut. We show that a host-constructed physical niche foregut binds with strain-level stabilizing their colonization. Primary colonizers saturate exclude secondary same strain, but initial colonization Lactobacillus physically remodels through production glycan-rich secretion favor unrelated commensals Acetobacter genus. Our results provide mechanistic framework understanding establishment multi-species intestinal microbiome.

Language: Английский

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The microbiome stabilizes circadian rhythms in the gut

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(5)

Published: Jan. 23, 2023

The gut microbiome is well known to impact host physiology and health. Given widespread control of by circadian clocks, we asked how the interacts with rhythms in Drosophila gut. did not cycle flies fed ad libitum, timed feeding (TF) drove limited cycling only clockless per01 flies. However, TF loss influenced composition transcriptome, independently together. Moreover, both interventions increased amplitude rhythmic gene expression, effects at least partly due changes histone acetylation. Contrary expectations, rendered animals more sensitive stress. Analysis function revealed that germ-free reset rapidly shifts light:dark cycle. We propose stabilizes prevent rapid fluctuations changing environmental conditions.

Language: Английский

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Environmental and Health Impacts of Graphene and Other Two-Dimensional Materials: A Graphene Flagship Perspective

ACS Nano, Journal Year: 2024, Volume and Issue: 18(8), P. 6038 - 6094

Published: Feb. 13, 2024

Two-dimensional (2D) materials have attracted tremendous interest ever since the isolation of atomically thin sheets graphene in 2004 due to specific and versatile properties these materials. However, increasing production use 2D necessitate a thorough evaluation potential impact on human health environment. Furthermore, harmonized test protocols are needed with which assess safety The Graphene Flagship project (2013-2023), funded by European Commission, addressed identification possible hazard graphene-based as well emerging including transition metal dichalcogenides, hexagonal boron nitride, others. Additionally, so-called green chemistry approaches were explored achieve goal safe sustainable this fascinating family nanomaterials. present review provides compact survey findings lessons learned Flagship.

Language: Английский

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Tools for Analysis of the Microbiome

Digestive Diseases and Sciences, Journal Year: 2020, Volume and Issue: 65(3), P. 674 - 685

Published: Jan. 31, 2020

Language: Английский

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Drosophila as a model for the gut microbiome

PLoS Pathogens, Journal Year: 2020, Volume and Issue: 16(4), P. e1008398 - e1008398

Published: April 23, 2020

Language: Английский

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Towards a mechanistic understanding of reciprocal drug–microbiome interactions

Molecular Systems Biology, Journal Year: 2021, Volume and Issue: 17(3)

Published: March 1, 2021

Broad-spectrum antibiotics target multiple gram-positive and gram-negative bacteria, can collaterally damage the gut microbiota. Yet, our knowledge of extent damage, antibiotic activity spectra, resistance mechanisms microbes is sparse. This limits ability to mitigate microbiome-facilitated spread resistance. In addition antibiotics, non-antibiotic drugs affect human microbiome, as shown by metagenomics well in vitro studies. Microbiome-drug interactions are bidirectional, also modulate drugs. Chemical modifications mostly function antimicrobial mechanisms, while metabolism non-antibiotics change drugs' pharmacodynamic, pharmacokinetic, toxic properties. Recent studies have started unravel extensive capacity metabolize drugs, relevance such events for drug treatment. These findings raise question whether which degree these reciprocal drug-microbiome will differ across individuals, how take them into account discovery precision medicine. review describes recent developments field discusses future study areas that benefit from systems biology approaches better understand mechanistic role microbiota actions.

Language: Английский

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