Frontiers in Plant Science,
Journal Year:
2020,
Volume and Issue:
11
Published: Nov. 9, 2020
The
molecular
basis
of
plant
immunity
triggered
by
microbial
pathogens
is
being
well
characterized
as
a
complex
sequential
process
leading
to
the
activation
defense
responses
at
infection
site,
but
which
may
also
be
systemically
expressed
in
all
organs,
phenomenon
known
systemic
acquired
resistance.
Some
plant-associated
and
beneficial
bacteria
are
able
stimulate
their
host
mount
defenses
against
pathogen
ingress
via
phenotypically
similar,
induced
resistance
phenomenon.
Induced
resembles
considering
its
mechanistic
principle
it
successively
involves
recognition
cell
surface,
stimulation
early
cellular
immune-related
events,
signaling
fine-tuned
hormonal
cross-talk
mechanisms.
It
thus
represents
an
indirect
efficient
mechanism
with
biocontrol
potential
improve
capacity
plants
restrict
invasion.
However,
according
our
current
vision,
specific
some
aspects
underpinning
these
different
steps.
Here
we
overview
chemical
diversity
compounds
that
have
been
identified
elicitors
thereby
illustrating
species
responsive
range
from
micro-
mesofauna
can
controlled
this
We
point
out
need
for
further
investigations
allowing
better
understanding
how
sensed
nature
stimulated
Natural Product Reports,
Journal Year:
2024,
Volume and Issue:
41(3), P. 469 - 511
Published: Jan. 1, 2024
A
lasso
peptide
takes
the
spotlight.
This
review
summarizes
30
years
of
research
on
microcin
J25
and
covers
everything
from
its
discovery
in
1992,
through
study
antimicrobial
activity,
to
most
recent
application
bioengineering.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Aug. 17, 2024
The
intratumor
microbiome
imbalance
in
pancreatic
cancer
promotes
a
tolerogenic
immune
response
and
triggers
immunotherapy
resistance.
Here
we
show
that
Lactobacillus
rhamnosus
GG
probiotics,
outfitted
with
gallium-polyphenol
network
(LGG@Ga-poly),
bolster
by
modulating
microbiota-immune
interactions.
Upon
oral
administration,
LGG@Ga-poly
targets
tumors
specifically,
selectively
eradicates
tumor-promoting
Proteobacteria
microbiota-derived
lipopolysaccharides
through
gallium-facilitated
disruption
of
bacterial
iron
respiration.
This
elimination
microbiota
impedes
the
activation
tumoral
Toll-like
receptors,
thus
reducing
immunosuppressive
PD-L1
interleukin-1β
expression
tumor
cells,
diminishing
immunotolerant
myeloid
populations,
improving
infiltration
cytotoxic
T
lymphocytes
tumors.
Moreover,
hampers
growth
both
preventive
therapeutic
contexts,
amplifies
antitumor
efficacy
checkpoint
blockade
preclinical
models
female
mice.
Overall,
offer
evidence
thoughtfully
designed
biomaterials
targeting
can
efficaciously
augment
for
challenging
cancer.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(12), P. 4365 - 4365
Published: June 19, 2020
Lipocalin-2
(LCN2)
is
a
secreted
glycoprotein
linked
to
several
physiological
roles,
including
transporting
hydrophobic
ligands
across
cell
membranes,
modulating
immune
responses,
maintaining
iron
homeostasis,
and
promoting
epithelial
differentiation.
Although
LNC2
expressed
at
low
levels
in
most
human
tissues,
it
abundant
aggressive
subtypes
of
cancer,
breast,
pancreas,
thyroid,
ovarian,
colon,
bile
duct
cancers.
High
LCN2
have
been
associated
with
increased
proliferation,
angiogenesis,
invasion,
metastasis.
Moreover,
modulates
the
degradation,
allosteric
events,
enzymatic
activity
matrix
metalloprotease-9,
metalloprotease
that
promotes
tumor
invasion
Hence,
has
emerged
as
potential
therapeutic
target
against
many
cancer
types.
This
review
summarizes
relevant
findings
regarding
expression,
biological
regulation
LCN2,
well
proteins
interacts
cancer.
We
also
discuss
approaches
targeting
for
treatment
are
currently
under
investigation,
use
interference
RNAs,
antibodies,
gene
editing.
Frontiers in Plant Science,
Journal Year:
2020,
Volume and Issue:
11
Published: Nov. 9, 2020
The
molecular
basis
of
plant
immunity
triggered
by
microbial
pathogens
is
being
well
characterized
as
a
complex
sequential
process
leading
to
the
activation
defense
responses
at
infection
site,
but
which
may
also
be
systemically
expressed
in
all
organs,
phenomenon
known
systemic
acquired
resistance.
Some
plant-associated
and
beneficial
bacteria
are
able
stimulate
their
host
mount
defenses
against
pathogen
ingress
via
phenotypically
similar,
induced
resistance
phenomenon.
Induced
resembles
considering
its
mechanistic
principle
it
successively
involves
recognition
cell
surface,
stimulation
early
cellular
immune-related
events,
signaling
fine-tuned
hormonal
cross-talk
mechanisms.
It
thus
represents
an
indirect
efficient
mechanism
with
biocontrol
potential
improve
capacity
plants
restrict
invasion.
However,
according
our
current
vision,
specific
some
aspects
underpinning
these
different
steps.
Here
we
overview
chemical
diversity
compounds
that
have
been
identified
elicitors
thereby
illustrating
species
responsive
range
from
micro-
mesofauna
can
controlled
this
We
point
out
need
for
further
investigations
allowing
better
understanding
how
sensed
nature
stimulated
