Post-translational regulation of autophagy is involved in intra-microbiome suppression of fungal pathogens DOI Creative Commons
Jing Wang,

Chaoyun Xu,

Qiming Sun

et al.

Microbiome, Journal Year: 2021, Volume and Issue: 9(1)

Published: June 6, 2021

Abstract Background Microbiome interactions are important determinants for ecosystem functioning, stability, and health. In previous studies, it was often observed that bacteria suppress potentially pathogenic fungal species part of the same plant microbiota; however, underlying microbe-microbe interplay remains mostly elusive. Here, we explored antagonistic fungus Fusarium graminearum bacterium Streptomyces hygroscopicus at molecular level. Both ubiquitous members healthy wheat under dysbiosis, causes devastating diseases. Results co-cultures, found alters acetylome leading to substantial induction autophagy . The secrets rapamycin inactivate target (TOR), which subsequently promotes degradation histone acetyltransferase Gcn5 through 26S proteasome. negatively regulates by acetylating autophagy-related protein Atg8 lysine site K13 blocking cellular relocalization Atg8. Thus, triggered reduce acetylation, resulting in F. Conclusions Autophagy homeostasis plays an essential role growth competition, as well virulence. Our work reveals a novel post-translational regulation initiated bacterial antibiotic. Rapamycin shown be powerful modulator bacteria–fungi with potential importance explaining microbial microbiomes. autophagic process provides possibilities targets biologically control pathogens.

Language: Английский

Effects of soil microbial ecology on ginsenoside accumulation in Panax ginseng across different cultivation years DOI
Jing Fang,

Zhefeng Xu,

Tao Zhang

et al.

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 215, P. 118637 - 118637

Published: May 8, 2024

Language: Английский

Citations

8
Aerial signaling by plant-associated Streptomyces setonii WY228 regulates plant growth and enhances salt stress tolerance DOI

Yue-Ying Qin,

Yuan Gong,

Su-Yun Kong

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 286, P. 127823 - 127823

Published: June 30, 2024

Language: Английский

Citations

8
Unraveling the interaction of dissolved organic matter and microorganisms with internal phosphorus cycling in the floodplain lake ecosystem DOI
Lan Lu, Ning Tang,

Ziqian Zhu

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 120966 - 120966

Published: Jan. 1, 2025

Language: Английский

Citations

1
Discovery of novel secondary metabolites encoded in actinomycete genomes through coculture DOI Creative Commons
Ji Hun Kim, Namil Lee, Soonkyu Hwang

et al.

Journal of Industrial Microbiology & Biotechnology, Journal Year: 2021, Volume and Issue: 48(3-4)

Published: Jan. 1, 2021

Abstract Actinomycetes are a rich source of bioactive natural products important for novel drug leads. Recent genome mining approaches have revealed an enormous number secondary metabolite biosynthetic gene clusters (smBGCs) in actinomycetes. However, under standard laboratory culture conditions, many smBGCs silent or cryptic. To activate these dormant smBGCs, several approaches, including culture-based genetic engineering-based strategies, been developed. Above all, coculture is promising approach to induce production from actinomycetes by mimicking ecological habitat where cryptic may be activated. In this review, we introduce studies that aim expand the chemical diversity actinomycetes, categorizing cases type partner. Furthermore, discuss current challenges need overcome support elicitation compounds

Language: Английский

Citations

50
Post-translational regulation of autophagy is involved in intra-microbiome suppression of fungal pathogens DOI Creative Commons
Jing Wang,

Chaoyun Xu,

Qiming Sun

et al.

Microbiome, Journal Year: 2021, Volume and Issue: 9(1)

Published: June 6, 2021

Abstract Background Microbiome interactions are important determinants for ecosystem functioning, stability, and health. In previous studies, it was often observed that bacteria suppress potentially pathogenic fungal species part of the same plant microbiota; however, underlying microbe-microbe interplay remains mostly elusive. Here, we explored antagonistic fungus Fusarium graminearum bacterium Streptomyces hygroscopicus at molecular level. Both ubiquitous members healthy wheat under dysbiosis, causes devastating diseases. Results co-cultures, found alters acetylome leading to substantial induction autophagy . The secrets rapamycin inactivate target (TOR), which subsequently promotes degradation histone acetyltransferase Gcn5 through 26S proteasome. negatively regulates by acetylating autophagy-related protein Atg8 lysine site K13 blocking cellular relocalization Atg8. Thus, triggered reduce acetylation, resulting in F. Conclusions Autophagy homeostasis plays an essential role growth competition, as well virulence. Our work reveals a novel post-translational regulation initiated bacterial antibiotic. Rapamycin shown be powerful modulator bacteria–fungi with potential importance explaining microbial microbiomes. autophagic process provides possibilities targets biologically control pathogens.

Language: Английский

Citations

47