Widespread exposure to SARS-CoV-2 in wildlife communities DOI Creative Commons
Amanda R. Goldberg, Kate E. Langwig, Katherine L. Brown

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 29, 2024

Pervasive SARS-CoV-2 infections in humans have led to multiple transmission events animals. While has a potential broad wildlife host range, most documented been captive animals and single species, the white-tailed deer. The full extent of exposure among communities factors that influence risk remain unknown. We sampled 23 species for examined effects urbanization human use on seropositivity. Here, we document positive detections RNA six including deer mouse, Virginia opossum, raccoon, groundhog, Eastern cottontail, red bat between May 2022-September 2023 across Washington, D.C., USA. In addition, found sites with high activity had three times higher seroprevalence than low human-use areas. obtained genomic sequences from nine individuals which were assigned seven Pango lineages Omicron variant. close match variants circulating at time suggests least recent human-to-animal events. Our data support widespread areas may serve as points contact cross-species transmission.

Language: Английский

Interface‐Engineered Field‐Effect Transistor Electronic Devices for Biosensing DOI
Yun Zhang, Duo Chen, He Wang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 4, 2023

Promising advances in molecular medicine have promoted the urgent requirement for reliable and sensitive diagnostic tools. Electronic biosensing devices based on field-effect transistors (FETs) exhibit a wide range of benefits, including rapid label-free detection, high sensitivity, easy operation, capability integration, possessing significant potential application disease screening health monitoring. In this perspective, tremendous efforts achievements development high-performance FET biosensors past decade are summarized, with emphasis interface engineering FET-based electrical platforms biomolecule identification. First, an overview strategies modulation recognition element design is discussed detail. For further step, applications vitro detection real-time monitoring biological systems comprehensively reviewed. Finally, key opportunities challenges electronic discussed. It anticipated that comprehensive understanding will inspire additional techniques developing highly sensitive, specific, stable as well emerging designs next-generation electronics.

Language: Английский

Citations

25
Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding DOI Creative Commons
Fanchong Jian, Leilei Feng, Sijie Yang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 31, 2023

Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) XBB lineages have achieved dominance worldwide and keep on evolving. Convergent evolution of the receptor-binding domain (RBD) L455F F456L is observed, resulting in variants like EG.5, FL.1.5.1, XBB.1.5.70, HK.3. Here, we show that neutralizing antibody (NAb) evasion drives convergent F456L, while epistatic shift caused by enables subsequent convergence through ACE2 binding enhancement further immune evasion. evade Class 1 NAbs, reducing neutralization efficacy breakthrough infection (BTI) reinfection convalescent plasma. Importantly, single substitution significantly dampens receptor binding; however, combination forms an adjacent residue flipping, which leads to enhanced NAbs resistance affinity. The perturbed mode exceptional NAb evasion, as revealed structural analyses. Our results indicate flexibility contributed epistasis cannot be underestimated, potential SARS-CoV-2 RBD remains high.

Language: Английский

Citations

22
Global spread of COVID-19's JN.1 variant: Implications and public health responses DOI Creative Commons
Prakasini Satapathy,

Pawan Kumar,

Vini Mehta

et al.

New Microbes and New Infections, Journal Year: 2024, Volume and Issue: 57, P. 101225 - 101225

Published: Feb. 5, 2024

Language: Английский

Citations

14
Molecular insights into the adaptive evolution of SARS-CoV-2 spike protein DOI Creative Commons
Zhuocheng Yao, Lin Zhang, Yuange Duan

et al.

Journal of Infection, Journal Year: 2024, Volume and Issue: 88(3), P. 106121 - 106121

Published: Feb. 16, 2024

The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has substantially damaged global economy and human health. spike (S) protein of coronaviruses plays a pivotal role in viral entry binding to host cell receptors. Additionally, it acts as primary target for neutralizing antibodies those infected is central focus currently utilized or researched vaccines. During virus's adaptation host, S SARS-CoV-2 undergone significant evolution. As pandemic unfolded, new mutations have arisen vanished, giving rise distinctive amino acid profiles within variant concern strains SARS-CoV-2. Notably, many these changes been positively selected, leading substantial alterations characteristics, such heightened transmissibility immune evasion capabilities. This review aims provide an overview our current understanding structural implications associated with key These research findings shed light on intricate dynamic nature evolution, underscoring importance continuous monitoring analysis genomes. Through molecular-level investigations, we can attain deeper insights into adaptive offering valuable guidance designing vaccines developing antiviral drugs combat ever-evolving threats.

Language: Английский

Citations

14
Widespread exposure to SARS-CoV-2 in wildlife communities DOI Creative Commons
Amanda R. Goldberg, Kate E. Langwig, Katherine L. Brown

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 29, 2024

Pervasive SARS-CoV-2 infections in humans have led to multiple transmission events animals. While has a potential broad wildlife host range, most documented been captive animals and single species, the white-tailed deer. The full extent of exposure among communities factors that influence risk remain unknown. We sampled 23 species for examined effects urbanization human use on seropositivity. Here, we document positive detections RNA six including deer mouse, Virginia opossum, raccoon, groundhog, Eastern cottontail, red bat between May 2022-September 2023 across Washington, D.C., USA. In addition, found sites with high activity had three times higher seroprevalence than low human-use areas. obtained genomic sequences from nine individuals which were assigned seven Pango lineages Omicron variant. close match variants circulating at time suggests least recent human-to-animal events. Our data support widespread areas may serve as points contact cross-species transmission.

Language: Английский

Citations

14