COVID,
Journal Year:
2024,
Volume and Issue:
4(9), P. 1440 - 1462
Published: Sept. 12, 2024
Long
COVID
comprises
persistent
symptoms
that
extend
beyond
four
weeks
post-SARS-CoV-2
infection.
The
potential
association
between
long
and
the
endorsement
of
COVID-19
conspiracy
theories
has
not
been
explored,
particularly
in
Arab
countries,
where
high
these
reported.
This
study
aimed
to
explore
endorsing
prevalence
self-reported
among
adults
Jordan
Kuwait
addition
other
countries.
employed
a
cross-sectional
design
using
Computer-Assisted
Web
Interviewing
(CAWI),
conducted
Arabic.
Recruitment
utilized
convenience-based
snowball
sampling
via
social
media
survey
was
distributed
July
2024.
manifestations
were
assessed
across
ten
recognized
symptoms,
belief
measured
five-point
Likert
scale
five
items.
final
sample
comprised
755
respondents,
majority
whom
history
confirmed
diagnosis
at
least
once
(n
=
493,
65.2%).
results
indicated
neutral
average
attitude
towards
(mean
score
15.18
±
4.64
out
30.00).
Participants
with
scores
more
likely
report
(aOR
6.85,
p
<
0.001)
or
middle
2.82,
0.008)
compared
those
lower
scores.
Additional
predictors
higher
reporting
included
female
sex,
household
income,
frequent
infections,
hospitalizations.
revealed
significant
correlation
frequency
magnitude
symptom
reporting.
findings
also
highlighted
influence
sociodemographic
factors
infection
on
reporting,
which
suggests
public
health
strategies
should
address
mitigate
challenges
effectively.
Journal of Proteome Research,
Journal Year:
2025,
Volume and Issue:
24(2), P. 499 - 514
Published: Jan. 13, 2025
Since
late
2021,
Omicron
variants
have
dominated
the
epidemiological
scenario
as
most
successful
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
sublineages,
driving
new
and
breakthrough
infections
globally
over
past
two
years.
In
this
study,
we
investigated
for
first
time
host
salivary
response
of
COVID-19
patients
infected
with
(BA.1,
BA.2,
BA.4/5)
by
using
an
untargeted
four-dimensional
data-independent
acquisition
(4D-DIA)-based
proteomics
approach.
We
identified
137
proteins
whose
abundance
levels
differed
between
positive
negative
groups.
Salivary
signatures
were
mainly
enriched
in
ribosomal
proteins,
linked
to
mRNAviral
translation,
protein
synthesis
processing,
immune
innate,
antiapoptotic
signaling.
The
higher
14-3-3
(YWHAG,
YWHAQ,
YWHAE,
SFN)
saliva,
reported
here,
may
be
associated
increased
infectivity
improved
viral
replicative
fitness.
also
seven
(ACTN1,
H2AC2,
GSN,
NDKA,
CD109,
GGH,
PCYOX)
that
yielded
comprehension
into
infection
performed
outstandingly
screening
a
hospital
setting.
This
panel
presented
enhanced
anti-COVID-19
anti-inflammatory
signature,
providing
insights
disease
severity,
supported
comparisons
other
proteome
data
sets.
signature
provided
valuable
host's
SARS-CoV-2
infection,
shedding
light
on
pathophysiology
COVID-19,
particularly
cases
mild
disease.
It
underscores
potential
clinical
applications
saliva
settings.
Data
are
available
via
ProteomeXchange
identifier
PXD054133.
npj Systems Biology and Applications,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: Jan. 13, 2025
Coronavirus
disease
2019
(COVID-19)
presents
a
wide
spectrum
of
symptoms,
the
causes
which
remain
poorly
understood.
This
study
explored
associations
between
autoantibodies
(AABs),
particularly
those
targeting
G
protein-coupled
receptors
(GPCRs)
and
renin‒angiotensin
system
(RAS)
molecules,
clinical
manifestations
COVID-19.
Using
cross-sectional
analysis
244
individuals,
we
applied
multivariate
variance,
principal
component
analysis,
multinomial
regression
to
examine
relationships
AAB
levels
key
symptoms.
Significant
correlations
were
identified
specific
AABs
symptoms
such
as
fever,
muscle
aches,
anosmia,
dysgeusia.
Notably,
anti-AGTR1
antibodies,
contribute
endothelial
glycocalyx
(eGC)
degradation,
process
reversed
by
losartan,
have
emerged
strong
predictors
core
increased
with
symptom
accumulation,
peaking
in
patients
exhibiting
all
four
These
findings
highlight
role
AABs,
determining
severity
suggest
their
involvement
pathophysiology
COVID-19,
including
vascular
complications.
The Obstetrician & Gynaecologist,
Journal Year:
2025,
Volume and Issue:
27(1), P. 43 - 56
Published: Jan. 1, 2025
Key
content
COVID‐19
is
known
to
be
associated
with
significant
morbidity
for
pregnant
women
and
their
babies.
This
susceptibility
adverse
clinical
outcomes
may
the
unique
physiological
characteristics
of
host.
Public
health
measures
recommended
management
prevention
critical
in
pregnancy
lactation
evolved
during
2020
pandemic;
some
decisions
were
controversial.
We
highlight
lessons
learnt
considerations
future
pandemic
preparedness.
Learning
objectives
To
outline
pathology
pregnancy,
including
placental
involvement.
summarise
current
evidence‐based
signpost
resources
updates.
discuss
role
vaccines
reduce
mortality
existing
novel
SARS‐CoV‐2
viral
strains.
Ethical
issues
Sustained
international
collaborative
strategies
are
crucial
ensure
global
equity
access
treatment
communicable
diseases.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: Feb. 17, 2025
Background
Most
children
in
Argentina
received
only
the
initial
COVID-19
vaccine
series,
with
presumed
hybrid
immunity
after
multiple
Omicron
waves.
However,
durability
of
immune
memory,
particularly
immunocompromised
(IC)
children,
remains
poorly
studied.
Methods
A
cohort
IC
(n=45)
and
healthy
(HC,
n=79)
was
assessed
between
13
to
17
months
receiving
two
or
three
doses
BBIBP-CorV
and/or
BNT162b2.
Plasma
anti-spike
IgG,
neutralizing
activity
antigen-specific
CD4+
CD8+
T
cells
against
Wuhan
BA.5
variants
were
assessed.
Results
remained
seropositive
doses,
but
compared
HC,
exhibited
lower
titers
both
BA.5,
those
vaccinated
BBIBP-CorV.
Even
showed
weaker
antibody
response,
cell
responses
IFN-γ
production
HC.
Integrated
analysis
antibodies,
memory
CD4
+
,
CD8
revealed
a
weak
among
an
important
compromise
responses.
Conclusions
Immunity
can
last
up
months,
reduced
effectiveness
new
highlights
need
for
updated
vaccines,
especially
children.
Additional
efforts
are
essential
enhance
vaccination
coverage
protect
this
vulnerable
population.
BMC Infectious Diseases,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 24, 2025
Identifying
individuals
hospitalized
for
SARS-CoV-2
infection
at
increased
risk
of
death
is
crucial
clinical
decision
making.
Analyses
must
consider
simultaneously
the
multitude
biomarkers
across
several
domains
and
how
these
biomarker
profiles
change
over
time.
This
electronic
health
records-based
study
included
a
Massachusetts
General
Brigham
hospital
least
24
h
within
5
days
prior
30
after
diagnosis
COVID-19.
K-means
clustering
was
used
to
identify
among
20
eligible
proportional
hazards
models
were
model
30-day
mortality
hospitalization
7
(i.e.,
landmark
models).
Twelve
thousand,
nine
hundred
forty-two
included,
whom
1,198
died
days.
Six
states
identified,
characterized
by
following
abnormalities:
(1)
normal/reference,
(2)
hematologic,
(3)
inflammatory
hematological,
(4)
metabolic,
(5)
kidney,
(6)
cardio-thrombotic,
liver,
metabolic.
Risk
higher
in
States
3,
4,
5,
6
(adjusted
hazard
ratios
ranging
from
3.6
7.8)
compared
State
1
hospitalization.
Landmark
findings
similar.
Distinct
sub-phenotypes
based
on
identified
patients
with
infection,
certain
phenotypes
are
associated
greater
mortality.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 2, 2025
Newly
emerging
SARS-CoV-2
variants
of
concern
(VOCs)
continue
to
drive
COVID-19
waves
and
are
typically
associated
with
immune
escape
increased
resistance
current
therapeutics
including
monoclonal
antibodies.
By
contrast,
VOCs
still
display
strong
binding
the
host
cell
receptor
ACE2.
Consistent
these
properties,
we
have
now
found
that
a
soluble
ACE2-Fc
decoy
produced
in
glycoengineered
plants
effectively
neutralizes
different
isolates
exhibits
even
potency
against
as
compared
an
ancestral
virus
strain.
In
golden
Syrian
hamster
model,
therapeutic
intranasal
delivery
reduced
weight
loss
replication
lungs
when
administered
24
h
post-inoculation.
This
protective
effect
was
not
observed
upon
treatment
infected
animals
non-binding
mutant,
demonstrating
plant-derived
interferes
specifically
attachment
cells.
The
results
obtained
provide
support
for
further
development
decoy-based
antiviral
approaches
by
plant
molecular
pharming.
