Application of machine learning for the analysis of peripheral blood biomarkers in oral mucosal diseases: a cross-sectional study DOI Creative Commons

Huiyu Yao,

Zhuo Cao,

Liang‐Fu Huang

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 10, 2025

Oral mucosal lesions are widespread globally, have a high prevalence in clinical practice, and significantly impact patients' quality of life. However, their pathogenesis remains unclear. Recent evidences suggested that hematological parameters may play role development. Our study investigated the differences humoral immune indexes, serum vitamin B levels, micronutrients among patients with oral healthy controls. Additionally, it evaluated Random Forest machine learning model for classifying various diseases based on peripheral blood biomarkers. We recruited 237 recurrent aphthous ulcers (RAU), 35 lichen planus (OLP), 67 atrophic glossitis (AG), burning mouth syndrome (BMS), 82 Clinical data were analyzed by SPSS 24 software. Serum levels immunoglobulins (IgG, IgA, IgM), complements (C3, C4), (VB1, VB2, VB3, VB5), zinc (Serum Zn), iron Fe), unsaturated iron-binding capacity (UIBC), total (TIBC), saturation (Iron Sat) measured compared groups. A was applied to analyze dataset comprising 319 samples eight key Significant observed between groups controls VB5, zinc, iron, TIBC, Iron Sat. Specifically, VB2 VB3 higher (*p < 0.05), while Zn, Fe, Sat lower 0.05). No significant found C3, C4, IgG, IgM, VB1, UIBC. The optimized demonstrated performance, effectively classified different disease groups, though some overlap noted. Feature importance analysis, Mean Decrease Accuracy Gini Index, identified Zn as biomarkers, indicating potential distinguishing diseases. associations contents other lesions. It regulating these micronutrient could be essential preventing curing such accuracy (94.68%) emphasizing enhance diagnostic precision Future research should focus validating findings larger cohorts exploring alternative machine-learning algorithms improve further.

Language: Английский

Shattering the Amyloid Illusion: The Microbial Enigma of Alzheimer’s Disease Pathogenesis—From Gut Microbiota and Viruses to Brain Biofilms DOI Creative Commons
Anna Onisiforou, Eleftheria G. Charalambous, Panos Zanos

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 90 - 90

Published: Jan. 5, 2025

For decades, Alzheimer's Disease (AD) research has focused on the amyloid cascade hypothesis, which identifies amyloid-beta (Aβ) as primary driver of disease. However, consistent failure Aβ-targeted therapies to demonstrate efficacy, coupled with significant safety concerns, underscores need rethink our approach AD treatment. Emerging evidence points microbial infections environmental factors in pathoetiology. Although a definitive causal link remains unestablished, collective is compelling. This review explores unconventional perspectives and emerging paradigms regarding involvement pathogenesis, emphasizing gut-brain axis, brain biofilms, oral microbiome, viral infections. Transgenic mouse models show that gut microbiota dysregulation precedes Aβ accumulation, signaling pathways. Viral like Herpes Simplex Virus Type 1 (HSV-1) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) may lead by modulating host processes immune system. peptide's antimicrobial function response infection might inadvertently promote AD. We discuss potential microbiome-based promising strategies for managing potentially preventing progression. Fecal transplantation (FMT) restores balance, reduces improves cognition preclinical models. Probiotics prebiotics reduce neuroinflammation plaques, while antiviral targeting HSV-1 vaccines shingles vaccine mitigate pathology. Developing effective treatments requires standardized methods identify measure patients, enabling personalized address individual contributions pathogenesis. Further needed clarify interactions between microbes Aβ, explore bacterial interplay, understand their broader effects translate these insights into clinical interventions.

Language: Английский

Citations

4
Microbes Saving Lives and Reducing Suffering DOI Creative Commons
Kenneth N. Timmis, Zeynep Ceren Karahan, Juan L. Ramos

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

Language: Английский

Citations

4
Dietary whey protein protects against Crohn’s disease by orchestrating cross-kingdom interaction between the gut phageome and bacteriome DOI

Runping Su,

Weijie Wen,

Yufeng Jin

et al.

Gut, Journal Year: 2025, Volume and Issue: unknown, P. gutjnl - 334516

Published: March 23, 2025

Background The gut microbiome and diet are important factors in the pathogenesis management of Crohn’s disease (CD). However, role phageome under dietary influences is unknown. Objective We aim to explore effect on phageome-bacteriome interaction linking CD protection. Design recruited patients healthy subjects (n=140) conducted a multiomics investigation, including paired ileal mucosa bacteriome profiling, survey phenome interrogation. screened for bacteriome, as well its epidemiological association with risks. underlying mechanisms were explored target phage-bacteria monocultures cocultures vitro two mouse models vivo. Results On screening humans, whey protein (WP) consumption was found profoundly impact (more pronounced phageome) associated lower risk. Indeed, WP reshaped can causally attenuate intestinal inflammation, shown by faecal versus transplantation from WP-consuming WP-non-consuming mice recipient mice. Mechanistically, induced phage (a newly isolated AkkZT003P herein) lysis mucin-foraging bacterium Akkermansia muciniphila , which unleashed symbiotic Streptococcus thermophilus counteract inflammation. Conclusion Our study charted importance cross-kingdom between bacteria mediating Importantly, we uncovered beneficial WP, keystone AkkZT003P, probiotic S. that be used future.

Language: Английский

Citations

1
Probiotics and prebiotics: new treatment strategies for oral potentially malignant disorders and gastrointestinal precancerous lesions DOI Creative Commons

Zhuwei Huang,

Julia Zhu,

Xiaobo Bu

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 8, 2025

Oral potentially malignant disorders (OPMDs) and gastrointestinal precancerous lesions (GPLs) are major public health concerns because of their potential to progress cancer. Probiotics, prebiotics, engineered probiotics can positively influence the prevention management OPMDs GPLs. This review aims comprehensively application status probiotics, prebiotics in GPLs, explore mechanisms action, anticipate future clinical use.

Language: Английский

Citations

1
Excess dietary sugar and its impact on periodontal inflammation: a narrative review DOI Creative Commons

Shashikiran Shanmugasundaram,

Shaswata Karmakar

BDJ Open, Journal Year: 2024, Volume and Issue: 10(1)

Published: Oct. 9, 2024

Sugar is omnipresent in the current food environment and sugar consumption has drastically risen over past century. Extensive evidence highlights negative health consequences of consuming excess dietary sugars, leading World Health Organization (WHO) American Heart Association (AHA) to devise guidelines restrict intake. According WHO's Global Oral Status Report 2022, oral diseases severe periodontitis are a massive public problem, sugars modifiable risk factor.

Language: Английский

Citations

5
Hydrogel design and applications for periodontitis therapy: A review DOI
Qingqing Pan, Zhihui Zong, Haibo Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137893 - 137893

Published: Nov. 1, 2024

Language: Английский

Citations

4
Causal relationship between 14 micronutrients and chronic periodontitis: a Mendelian randomization study DOI Open Access
Zongliang Yu, Yang Yang, Zongliang Yu

et al.

Australian Dental Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Chronic periodontitis is one of the most common inflammatory diseases worldwide. Micronutrients play a significant impact on health and periodontal disease progression. However, there still lack conclusive studies confirming causal association micronutrients with chronic periodontitis.

Language: Английский

Citations

0
Alterations in the Tongue Coating Microbiome in Patients With Diarrhea‐Predominant Irritable Bowel Syndrome: A Cross‐Sectional Study DOI Open Access
Yitong Li, Yuhe Mai, Jiao Yao

et al.

Apmis, Journal Year: 2025, Volume and Issue: 133(2)

Published: Feb. 1, 2025

The gut microbiota plays a critical role in the occurrence and development of IBS-D, however, IBS-D-associated tongue coating microbiome dysbiosis has not yet been clearly defined. To address this, we analyzed structure composition 23 IBS-D patients 12 healthy controls using 16S rRNA high-throughput sequencing analysis. results revealed that overall observed OTUs exhibited significant decrease compared with controls. Alpha diversity analysis showed community richness were significantly reduced patients, PCoA distinct clustering between Microbial comparisons at genus level abundance Veillonella, Prevotella was higher than those controls, while Streptococcus, Haemophilus, Granulicatella, Rothia volunteers. Functional differences 88 functional metabolic pathways including fatty acid biosynthesis. These findings identified structure, composition, functionality hold promise potential for therapeutic targets during management.

Language: Английский

Citations

0
Causal Association Between Microbiome and Oral-Oropharyngeal Cancer: A Mendelian Randomization Study DOI Creative Commons
Zhengrui Li, Xufeng Huang, Qi Wang

et al.

International Dental Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Response to editorial “Oral health in southeast Asia: addressing inaccessibility” DOI Creative Commons
Romain Lan, Laurie Fraticelli, Denis Bourgeois

et al.

The Lancet Regional Health - Southeast Asia, Journal Year: 2025, Volume and Issue: unknown, P. 100550 - 100550

Published: Feb. 1, 2025

Language: Английский

Citations

0