Cell, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Molecular Cell, Journal Year: 2022, Volume and Issue: 82(5), P. 986 - 1002.e9
Published: Feb. 18, 2022
Language: Английский
Citations
71
Cell, Journal Year: 2023, Volume and Issue: 186(24), P. 5308 - 5327.e25
Published: Nov. 1, 2023
Mammalian oocytes are filled with poorly understood structures called cytoplasmic lattices. First discovered in the 1960s and speculated to correspond mammalian yolk, ribosomal arrays, or intermediate filaments, their function has remained enigmatic date. Here, we show that lattices sites where store essential proteins for early embryonic development. Using super-resolution light microscopy cryoelectron tomography, composed of filaments a high surface area, which contain PADI6 subcortical maternal complex proteins. The associate many critical development, including control epigenetic reprogramming preimplantation embryo. Loss by knocking out prevents accumulation these results arrest. Our work suggests enrich maternally provided prevent premature degradation cellular activity, thereby enabling
Language: Английский
Citations
62
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: April 19, 2024
The transition from oviparity to viviparity and the establishment of feto-maternal communications introduced placenta as major anatomical site provide nutrients, gases, hormones developing fetus. has endocrine functions, orchestrates maternal adaptations pregnancy at different periods pregnancy, acts a selective barrier minimize exposure fetus xenobiotics, pathogens, parasites. Despite fact that this ancient organ is central for normal in eutherians, remains one least studied organs. first step embryo implantation, finely regulated by trophoectoderm, precursor all trophoblast cells. There bidirectional communication between endometrium leading decidualization, critical maintenance pregnancy. are three-direction interactions placenta, immune cells, adaptation endometrial system allogeneic While 65% systemically expressed human proteins have been found tissues, it expresses numerous placenta-specific proteins, whose expression dramatically changed gestational diseases could serve biomarkers early detection diseases. Surprisingly, placentation carcinogenesis exhibit shared features metabolism cell behavior, molecular signatures, signaling pathways, tissue microenvironment, which proposes concept "cancer ectopic trophoblastic cells". By extensive researches novel field, handful cancer discovered. This review paper, inspired part our experiences during past couple years, highlights new aspects placental functions with emphasis on its immunomodulatory role successful potential link carcinogenesis.
Language: Английский
Citations
19
Cell Reports, Journal Year: 2024, Volume and Issue: 43(4), P. 114118 - 114118
Published: April 1, 2024
Zygotic genome activation (ZGA) after fertilization enables the maternal-to-zygotic transition. However, global view of ZGA, particularly at initiation, is incompletely understood. Here, we develop a method to capture and sequence newly synthesized RNA in early mouse embryos, providing transcriptional reprogramming during ZGA. Our data demonstrate that major ZGA gene begins earlier than previously thought. Furthermore, identify set genes activated minor promoters which show enrichment Obox factor motif, find Obox3 or Obox5 overexpression embryonic stem cells activates genes. Notably, expression factors severely impaired somatic cell nuclear transfer (SCNT) restoration corrects profile greatly improves SCNT embryo development. Hence, our study reveals dynamic underscores crucial role facilitating totipotency acquisition.
Language: Английский
Citations
17
Cell, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
4