CDK13 cooperates with CDK12 to control global RNA polymerase II processivity DOI Creative Commons
Zheng Fan, Jennifer R. Devlin, Simon J. Hogg

et al.

Science Advances, Journal Year: 2020, Volume and Issue: 6(18)

Published: April 29, 2020

CDK12 and CDK13 regulate POLII elongation rate processivity influence the selection of transcription termination sites.

Language: Английский

Organization and regulation of gene transcription DOI
Patrick Cramer

Nature, Journal Year: 2019, Volume and Issue: 573(7772), P. 45 - 54

Published: Aug. 28, 2019

Language: Английский

Citations

621

The DNA damage response to transcription stress DOI
Hannes Lans, Jan H.J. Hoeijmakers, Wim Vermeulen

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 20(12), P. 766 - 784

Published: Sept. 26, 2019

Language: Английский

Citations

267

Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy DOI
Jonathan Chou, David A. Quigley, Troy M. Robinson

et al.

Cancer Discovery, Journal Year: 2020, Volume and Issue: 10(3), P. 351 - 370

Published: Feb. 18, 2020

Drugs targeting the cell cycle-regulatory cyclin-dependent kinase (CDK) 4 and 6 have been approved for treatment of hormone receptor-positive breast cancer, inhibitors other cell-cycle CDKs are currently in clinical trials. Another class CDKs, transcription-associated including CDK7, CDK8, CDK9, CDK12 CDK13, critical regulators gene expression. Recent evidence suggests several novel functions these regulation epigenetic modifications, intronic polyadenylation, DNA-damage responses, genomic stability. Here, we summarize our current understanding transcriptional their utility as biomarkers, potential therapeutic targets. SIGNIFICANCE: CDK CDK4 CDK6 Several studies now point to opportunities by inhibiting well vulnerabilities with PARP immunotherapy tumors deficient CDKs.

Language: Английский

Citations

236

Nascent RNA analyses: tracking transcription and its regulation DOI
Erin M. Wissink, Anniina Vihervaara, Nathaniel D. Tippens

et al.

Nature Reviews Genetics, Journal Year: 2019, Volume and Issue: 20(12), P. 705 - 723

Published: Aug. 9, 2019

Language: Английский

Citations

225

The Mediator complex as a master regulator of transcription by RNA polymerase II DOI Open Access
William F. Richter, Shraddha Nayak, Janet Iwasa

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 23(11), P. 732 - 749

Published: June 20, 2022

Language: Английский

Citations

198

Causes and consequences of RNA polymerase II stalling during transcript elongation DOI
Melvin Noé González, Daniel Blears, Jesper Q. Svejstrup

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 22(1), P. 3 - 21

Published: Nov. 18, 2020

Language: Английский

Citations

193

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer DOI Creative Commons
Stephin J. Vervoort, Sarah A. Welsh, Jennifer R. Devlin

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(12), P. 3143 - 3162.e32

Published: May 17, 2021

Language: Английский

Citations

167

Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase DOI
Hai Zheng, Yilun Qi, Shibin Hu

et al.

Science, Journal Year: 2020, Volume and Issue: 370(6520)

Published: Nov. 27, 2020

Dephosphorylating RNA polymerase II Transcription in metazoans requires coordination of multiple factors to control the progression polymerases and integrity their products. Zheng et al. identified a new dual-enzyme complex called INTAC, which is composed protein phosphatase 2A (PP2A) core enzyme multisubunit endonuclease Integrator. Structural functional studies show that INTAC functions as noncanonical PP2A holoenzyme dephosphorylates C-terminal domain attenuate transcription. This study provides direct connection between PP2A-mediated dephosphorylation transcriptional regulation, two fundamental cellular processes. Science , this issue p. eabb5872

Language: Английский

Citations

161

Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release DOI Creative Commons
Takeo Narita, Shinsuke Ito, Yoshiki Higashijima

et al.

Molecular Cell, Journal Year: 2021, Volume and Issue: 81(10), P. 2166 - 2182.e6

Published: March 24, 2021

Language: Английский

Citations

155

NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release DOI Creative Commons
Yuki Aoi, Edwin R. Smith, Avani P. Shah

et al.

Molecular Cell, Journal Year: 2020, Volume and Issue: 78(2), P. 261 - 274.e5

Published: March 9, 2020

Language: Английский

Citations

149