
Science Advances, Journal Year: 2020, Volume and Issue: 6(18)
Published: April 29, 2020
CDK12 and CDK13 regulate POLII elongation rate processivity influence the selection of transcription termination sites.
Language: Английский
Science Advances, Journal Year: 2020, Volume and Issue: 6(18)
Published: April 29, 2020
CDK12 and CDK13 regulate POLII elongation rate processivity influence the selection of transcription termination sites.
Language: Английский
Nature, Journal Year: 2019, Volume and Issue: 573(7772), P. 45 - 54
Published: Aug. 28, 2019
Language: Английский
Citations
621Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 20(12), P. 766 - 784
Published: Sept. 26, 2019
Language: Английский
Citations
267Cancer Discovery, Journal Year: 2020, Volume and Issue: 10(3), P. 351 - 370
Published: Feb. 18, 2020
Drugs targeting the cell cycle-regulatory cyclin-dependent kinase (CDK) 4 and 6 have been approved for treatment of hormone receptor-positive breast cancer, inhibitors other cell-cycle CDKs are currently in clinical trials. Another class CDKs, transcription-associated including CDK7, CDK8, CDK9, CDK12 CDK13, critical regulators gene expression. Recent evidence suggests several novel functions these regulation epigenetic modifications, intronic polyadenylation, DNA-damage responses, genomic stability. Here, we summarize our current understanding transcriptional their utility as biomarkers, potential therapeutic targets. SIGNIFICANCE: CDK CDK4 CDK6 Several studies now point to opportunities by inhibiting well vulnerabilities with PARP immunotherapy tumors deficient CDKs.
Language: Английский
Citations
236Nature Reviews Genetics, Journal Year: 2019, Volume and Issue: 20(12), P. 705 - 723
Published: Aug. 9, 2019
Language: Английский
Citations
225Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 23(11), P. 732 - 749
Published: June 20, 2022
Language: Английский
Citations
198Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 22(1), P. 3 - 21
Published: Nov. 18, 2020
Language: Английский
Citations
193Cell, Journal Year: 2021, Volume and Issue: 184(12), P. 3143 - 3162.e32
Published: May 17, 2021
Language: Английский
Citations
167Science, Journal Year: 2020, Volume and Issue: 370(6520)
Published: Nov. 27, 2020
Dephosphorylating RNA polymerase II Transcription in metazoans requires coordination of multiple factors to control the progression polymerases and integrity their products. Zheng et al. identified a new dual-enzyme complex called INTAC, which is composed protein phosphatase 2A (PP2A) core enzyme multisubunit endonuclease Integrator. Structural functional studies show that INTAC functions as noncanonical PP2A holoenzyme dephosphorylates C-terminal domain attenuate transcription. This study provides direct connection between PP2A-mediated dephosphorylation transcriptional regulation, two fundamental cellular processes. Science , this issue p. eabb5872
Language: Английский
Citations
161Molecular Cell, Journal Year: 2021, Volume and Issue: 81(10), P. 2166 - 2182.e6
Published: March 24, 2021
Language: Английский
Citations
155Molecular Cell, Journal Year: 2020, Volume and Issue: 78(2), P. 261 - 274.e5
Published: March 9, 2020
Language: Английский
Citations
149