Physiological and Molecular Dissection of Daily Variance in Exercise Capacity DOI Creative Commons

Saar Ezagouri,

Ziv Zwighaft,

Jonathan Sobel

et al.

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(1), P. 78 - 91.e4

Published: April 18, 2019

Language: Английский

Basic helix–loop–helix ARNT like 1 regulates the function of immune cells and participates in the development of immune-related diseases DOI Creative Commons
Fanglin Shao, Zhipeng Wang,

Luxia Ye

et al.

Burns & Trauma, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 1, 2025

The circadian clock is an internal timekeeper system that regulates biological processes through a central and peripheral clocks controlling various genes. Basic helix-loop-helix ARNT-like 1 (BMAL1), also known as aryl hydrocarbon receptor nuclear translocator-like protein (ARNTL1), key component of the clock. deletion BMAL1 alone can abolish rhythms human body. plays critical role in immune cell function. Dysregulation linked to immune-related diseases such autoimmune diseases, infectious cancer, vice versa. This review highlights significant governing cells, including their development, differentiation, migration, homing, metabolism, effector functions. study explores how dysregulation have far-reaching implications potentially contribute onset sepsis, trauma. Furthermore, this discusses treatments for target disorders. Understanding impact on function provide insights into pathogenesis help development more effective treatment strategies. Targeting has been demonstrated achieve good efficacy indicating its promising potential targetable therapeutic these diseases.

Language: Английский

Citations

4
The hepatic clock synergizes with HIF-1α to regulate nucleotide availability during liver damage repair DOI

Linyuan Peng,

Siliang Xiang,

Tianzhi Wang

et al.

Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

3
Circadian clock communication during homeostasis and ageing DOI
Thomas Mortimer, Jacob G. Smith, Pura Muñoz‐Cánoves

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Language: Английский

Citations

2
Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke DOI Creative Commons
Huaqiang Li, Xiaohua Ke, Bainian Feng

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 22, 2025

Post-stroke cognitive impairment (PSCI) is a common complication following stroke that significantly affects patients’ quality of life and rehabilitation outcomes. It also imposes heavy economic burden. There an urgent need to better understand the pathophysiology pathogenesis PSCI, as well identify markers can predict PSCI early in clinical stage, facilitating prevention, monitoring, treatment. Although mechanisms underlying are complex multifaceted, involving factors such atherosclerosis neuroinflammation, metabolic disorders play critical role. This article primarily reviews relationship between three major nutrients—sugar, fat, protein—and development dysfunction ischemic (IS). aims elucidate how these disturbances contribute post-stroke explore potential biomarkers for PSCI. We believe this review will offer new insights into identification, treatment, prognostic assessment

Language: Английский

Citations

2
Physiological and Molecular Dissection of Daily Variance in Exercise Capacity DOI Creative Commons

Saar Ezagouri,

Ziv Zwighaft,

Jonathan Sobel

et al.

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(1), P. 78 - 91.e4

Published: April 18, 2019

Language: Английский

Citations

139