Reciprocal regulation of mesenchymal stem cells and immune responses

Cell stem cell, Journal Year: 2022, Volume and Issue: 29(11), P. 1515 - 1530

Published: Nov. 1, 2022

Language: Английский

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T cell regeneration after immunological injury

Nature reviews. Immunology, Journal Year: 2020, Volume and Issue: 21(5), P. 277 - 291

Published: Oct. 23, 2020

Language: Английский

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Leukaemia: a model metastatic disease

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(7), P. 461 - 475

Published: May 5, 2021

Language: Английский

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Hematopoiesis and Cardiovascular Disease

Circulation Research, Journal Year: 2020, Volume and Issue: 126(8), P. 1061 - 1085

Published: April 9, 2020

A central feature of atherosclerosis, the most prevalent chronic vascular disease and root cause myocardial infarction stroke, is leukocyte accumulation in arterial wall. These crucial immune cells are produced specialized niches bone marrow, where a complex cell network orchestrates their production release. growing body clinical studies has documented correlation between numbers cardiovascular risk. Understanding how leukocytes they contribute to atherosclerosis its complications is, therefore, critical understanding treating disease. In this review, we focus on key products that regulate hematopoiesis under homeostatic conditions, during after infarction.

Language: Английский

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Cell therapies in the clinic

Bioengineering & Translational Medicine, Journal Year: 2021, Volume and Issue: 6(2)

Published: Feb. 14, 2021

Abstract Cell therapies have emerged as a promising therapeutic modality with the potential to treat and even cure diverse array of diseases. offer unique clinical advantages over conventional small molecules growing number biologics. Particularly, living cells can simultaneously dynamically perform complex biological functions in ways that drugs cannot; cell expanded spectrum available options include key cellular processes. As such, are currently one most investigated modalities both preclinical settings, many products having been approved more under active investigation. Here, we highlight diversity discuss their current advances. In particular, review 28 globally therapy use. We also analyze >1700 trials therapies, an emphasis on discussing applications. Finally, critically major biological, manufacturing, regulatory challenges associated translation therapies.

Language: Английский

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Mesenchymal stem cells and their microenvironment

Stem Cell Research & Therapy, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 20, 2022

Abstract Mesenchymal stem cells (MSCs), coming from a wide range of sources, have multi-directional differentiation ability. MSCs play vital roles in immunomodulation, hematopoiesis and tissue repair. The microenvironment often refers to the intercellular matrix, other cells, cytokines humoral components. It is also place for cells’ interaction. stability pivotal maintaining cell proliferation, differentiation, metabolism functional activities. Abnormal changes components can interfere functions. In some diseases, interact with accelerate disease progression. This review will discuss characteristics their microenvironment, as well interaction between disease.

Language: Английский

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Leukemic stem cells and therapy resistance in acute myeloid leukemia

Haematologica, Journal Year: 2023, Volume and Issue: 108(2), P. 353 - 366

Published: Feb. 1, 2023

A major obstacle in the treatment of acute myeloid leukemia (AML) is refractory disease or relapse after achieving remission. The latter arises from a few therapy-resistant cells within minimal residual (MRD). Resistant with long-term self-renewal capacity that drive clonal outgrowth are referred to as leukemic stem (LSC). cancer cell concept considers LSC relapse-initiating residing at top each genetically defined AML subclone forming epigenetically controlled downstream hierarchies. display significant phenotypic and epigenetic plasticity, particularly response therapy stress, which results various mechanisms mediating resistance. Given inherent chemotherapy resistance LSC, targeted strategies must be incorporated into first-line regimens prevent LSC-mediated relapse. combination venetoclax azacitidine promising current strategy for LSC. Nevertheless, selection patients who would benefit either standard + has yet established still need discovered overcome. Clinical trials currently underway investigate susceptibility therapies. era single-cell multi-omics begun uncover complex cellular architectures associated biological networks. This should lead better understanding highly heterogeneous inter- intra-patient level identify by longitudinal analysis patients' samples. review discusses biology mechanisms, potential therapeutic vulnerabilities clinical trial activities.

Language: Английский

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Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing

Nature Cell Biology, Journal Year: 2023, Volume and Issue: 25(1), P. 30 - 41

Published: Jan. 1, 2023

Language: Английский

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Characteristics of the cancer stem cell niche and therapeutic strategies

Stem Cell Research & Therapy, Journal Year: 2022, Volume and Issue: 13(1)

Published: June 3, 2022

Distinct regions harboring cancer stem cells (CSCs) have been identified within the microenvironment of various tumors, and as in case their healthy counterparts, these anatomical are termed "niche." Thus far, a large volume studies shown that CSC niches take part maintenance, regulation renewal, differentiation plasticity CSCs. In this review, we summarize discuss latest findings regarding niche morphology, physical terrain, main signaling pathways interactions them. The cellular molecular components CSCs also involve genetic epigenetic modulations mediate support ultimately leading to progression. It suggests crosstalk between plays an important role therapy resistance recurrence. addition, updated diverse therapeutic strategies different cancers basic research clinical trials review. Understanding complex heterogeneity is necessary pre-requisite for designing superior target CSC-specific factors and/or niche.

Language: Английский

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Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis

Cell Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: July 2, 2024

Abstract The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo differentiation into osteoblasts. This process plays a crucial role in bone formation and homeostasis is regulated by two intricate processes: cell signal transduction transcriptional gene expression. Various essential signaling pathways, including Wnt, BMP, TGF-β, Hedgehog, PTH, FGF, Ephrin, Notch, Hippo, Piezo1/2, play critical facilitating osteoblast differentiation, formation, homeostasis. Key factors this include Runx2, Cbfβ, Runx1, Osterix, ATF4, SATB2, TAZ/YAP. Furthermore, diverse array epigenetic also roles at the level. review provides an overview latest developments current comprehension concerning pathways signaling, regulation hormones, genes involved commitment lineage, well maintenance paper reviews via mechanisms, such histone DNA modifications. Additionally, we summarize biology spurred recent advancements various modern technologies bioinformatics. By synthesizing these insights comprehensive understanding further clarification mechanisms underlying lineage commitment, highlights potential new therapeutic applications for treatment diseases.

Language: Английский

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