Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy

Nature Immunology, Journal Year: 2023, Volume and Issue: 24(8), P. 1244 - 1255

Published: July 6, 2023

Language: Английский

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IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy

Biotechnology Advances, Journal Year: 2023, Volume and Issue: 67, P. 108169 - 108169

Published: May 18, 2023

Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential for the structure and function of IgG. IgG glycome relatively stable in state homeostasis, yet its alterations have been associated with aging, pollution toxic exposure, as well various diseases, including autoimmune inflammatory cardiometabolic infectious diseases cancer. also an effector molecule directly involved inflammation processes included pathogenesis many diseases. Numerous recently published studies support idea that N-glycosylation fine-tunes immune response plays significant role chronic inflammation. This makes it promising novel biomarker biological age, prognostic, diagnostic treatment evaluation tool. Here we provide overview current knowledge regarding health disease, potential applications pro-active prevention monitoring interventions.

Language: Английский

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Glycosylation: mechanisms, biological functions and clinical implications

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 5, 2024

Protein post-translational modification (PTM) is a covalent process that occurs in proteins during or after translation through the addition removal of one more functional groups, and has profound effect on protein function. Glycosylation most common PTMs, which polysaccharides are transferred to specific amino acid residues by glycosyltransferases. A growing body evidence suggests glycosylation essential for unfolding various activities organisms, such as playing key role regulation function, cell adhesion immune escape. Aberrant also closely associated with development diseases. Abnormal patterns linked emergence health conditions, including cancer, inflammation, autoimmune disorders, several other However, underlying composition structure glycosylated have not been determined. It imperative fully understand internal differential expression glycosylation, incorporate advanced detection technologies keep knowledge advancing. Investigations clinical applications focused sensitive promising biomarkers, effective small molecule targeted drugs emerging vaccines. These studies provide new area novel therapeutic strategies based glycosylation.

Language: Английский

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Impact of structural modifications of IgG antibodies on effector functions

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Immunoglobulin G (IgG) antibodies are a critical component of the adaptive immune system, binding to and neutralizing pathogens other foreign substances. Recent advances in molecular antibody biology structural protein engineering enabled modification IgG enhance their therapeutic potential. This review summarizes recent progress both natural engineered modifications antibodies, including allotypic variation, glycosylation, Fc engineering, gamma receptor optimization. We discuss functional consequences these highlight potential for therapeutical applications.

Language: Английский

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Glycan-specific molecularly imprinted polymers towards cancer diagnostics: merits, applications, and future perspectives

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(4), P. 1870 - 1891

Published: Jan. 1, 2024

This review surveys glycans as biomarkers and challenges in using glycan-binding receptors for cancer diagnosis. We highlight merits, applications, future directions of molecularly imprinted polymers effective receptors.

Language: Английский

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