DNA methylation in newborns conceived by assisted reproductive technology DOI Creative Commons
Siri E. Håberg, Christian M. Page, Yunsung Lee

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: April 7, 2022

Assisted reproductive technology (ART) may affect fetal development through epigenetic mechanisms as the timing of ART procedures coincides with extensive remodeling occurring between fertilization and embryo implantation. However, it is unknown to what extent alter epigenome. Underlying parental characteristics subfertility also play a role. Here we identify differences in cord blood DNA methylation, measured using Illumina EPIC platform, 962 conceived 983 naturally singleton newborns. We show that newborns display widespread overall less methylation across genome. There were 607 genome-wide differentially methylated CpGs. find 176 known genes, including genes related growth, neurodevelopment, other health outcomes have been associated ART. Both fresh frozen transfer differences. Associations persist after controlling for parents' are not explained by subfertility.

Language: Английский

DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy DOI Creative Commons
Ruixue Huang, Ping‐Kun Zhou

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: July 9, 2021

Abstract Genomic instability is the hallmark of various cancers with increasing accumulation DNA damage. The application radiotherapy and chemotherapy in cancer treatment typically based on this property cancers. However, adverse effects including normal tissues injury are also accompanied by chemotherapy. Targeted therapy has potential to suppress cells’ damage response through tailoring patients lacking specific functions. Obviously, understanding broader role repair became a basic attractive strategy for targeted therapy, particular, raising novel hypothesis or theory field basis previous scientists’ findings would be important future promising druggable emerging targets. In review, we first illustrate timeline steps roles promotion developed, then summarize mechanisms regarding associated highlighting proteins behind targeting that initiate functioning abnormally duo extrinsic harm environmental factors, also, baseline drift leads harmful intrinsic therapy. addition, clinical therapeutic drugs effects, as well scheme relative trials were intensive discussed. Based background, suggest two hypotheses, namely “environmental gear selection” describe pathway evolution, “DNA drift”, which may play magnified mediating during treatment. This new shed light provide much better more comprehensive holistic view promote development research direction overcoming strategies patients.

Language: Английский

Citations

518
Targeting DNA damage response pathways in cancer DOI
Florian J. Groelly,

Matthew Fawkes,

Rebecca A. Dagg

et al.

Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 23(2), P. 78 - 94

Published: Dec. 5, 2022

Language: Английский

Citations

461
Regulating tumor suppressor genes: post-translational modifications DOI Creative Commons
Ling Chen, Shuang Liu, Yongguang Tao

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: June 10, 2020

Abstract Tumor suppressor genes cooperate with each other in tumors. Three important tumor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted on chromosome ten (PTEN) are functionally associated they regulated by post-translational modification (PTMs) as well. PTMs include phosphorylation, SUMOylation, acetylation, novel modifications becoming growing appreciated. Because most of reversible, normal cells use them a switch to control the state being resting or proliferating, also involve cell survival cycle, which may lead abnormal proliferation tumorigenesis. Although lot studies focus importance kind PTM, further discoveries shows that (TSGs) form complex “network” interaction modification. Recently, there several promising strategies for TSGs change more frequently than carcinogenic cancers. We here review necessity, characteristics, mechanisms Rb, PTEN, its influence precise selective function. discuss current antitumoral therapies p53 PTEN predictive, prognostic, therapeutic target cancer.

Language: Английский

Citations

329
Programmed death ligand 1 signals in cancer cells DOI

Anand Kornepati,

Ratna K. Vadlamudi, Tyler J. Curiel

et al.

Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 22(3), P. 174 - 189

Published: Jan. 14, 2022

Language: Английский

Citations

270
DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing DOI

Chaoyou Xue,

Eric C. Greene

Trends in Genetics, Journal Year: 2021, Volume and Issue: 37(7), P. 639 - 656

Published: April 22, 2021

Language: Английский

Citations

268
DNA Damage and Cancer Immunotherapy: A STING in the Tale DOI Creative Commons
Timo Reisländer, Florian J. Groelly, Madalena Tarsounas

et al.

Molecular Cell, Journal Year: 2020, Volume and Issue: 80(1), P. 21 - 28

Published: Aug. 17, 2020

Language: Английский

Citations

247
H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids DOI Open Access
Kyosuke Nakamura, Giulia Saredi, Jordan R. Becker

et al.

Nature Cell Biology, Journal Year: 2019, Volume and Issue: 21(3), P. 311 - 318

Published: Feb. 25, 2019

Language: Английский

Citations

175
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells DOI
Priyanka Verma, Yeqiao Zhou,

Zhendong Cao

et al.

Nature Cell Biology, Journal Year: 2021, Volume and Issue: 23(2), P. 160 - 171

Published: Jan. 18, 2021

Language: Английский

Citations

122
Mechanisms of BRCA1–BARD1 nucleosome recognition and ubiquitylation DOI
Qi Hu, Maria Victoria Botuyan, Debiao Zhao

et al.

Nature, Journal Year: 2021, Volume and Issue: 596(7872), P. 438 - 443

Published: July 28, 2021

Language: Английский

Citations

111
DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities DOI Creative Commons

Yasser Abuetabh,

Hong Wu, Chengsen Chai

et al.

Experimental & Molecular Medicine, Journal Year: 2022, Volume and Issue: 54(10), P. 1658 - 1669

Published: Oct. 7, 2022

Abstract Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to eradicate and inhibit growth cancer cells are integral approaches therapy. Although DNA-damaging therapies advance battle with cancer, resistance, recurrence following treatment common. Thus, searching for vulnerabilities facilitate action agents by sensitizing is an active research area. Therefore, it crucial decipher detailed molecular events involved in responses (DDRs) cancer. The tumor suppressor p53 at hub DDR. Researchers have identified increasing number genes regulated transcriptional functions been shown be critical direct or indirect mediators cell fate, cycle regulation, repair. Posttranslational modifications (PTMs) primarily orchestrate activity response damage. Many molecules mediating PTMs identified. anticancer potential realized targeting these has through experiments clinical trials sensitize agents. This review briefly acknowledges complexity DDR pathways/networks. We specifically focus regulators, protein kinases, E3/E4 ubiquitin ligases their potential.

Language: Английский

Citations

109