Science Advances,
Journal Year:
2023,
Volume and Issue:
9(42)
Published: Oct. 18, 2023
Dysregulation
of
CD4+
T
cell
differentiation
is
linked
to
autoimmune
diseases.
Metabolic
reprogramming
from
oxidative
phosphorylation
glycolysis
and
accumulation
lactate
are
involved
in
this
process.
However,
the
underlying
mechanisms
remain
unclear.
Our
study
showed
that
lactate-derived
lactylation
regulated
differentiation.
Lactylation
levels
cells
increased
with
progression
experimental
uveitis
(EAU).
Inhibition
suppressed
TH17
attenuated
EAU
inflammation.
The
global
lactylome
revealed
landscape
lactylated
sites
proteins
normal
mice.
Specifically,
hyperlactylation
Ikzf1
at
Lys164
promoted
by
directly
modulating
expression
TH17-related
genes,
including
Runx1,
Tlr4,
interleukin-2
(IL-2),
IL-4.
Delactylation
impaired
These
findings
exemplify
how
regulates
site
specificity
protein
promote
implicate
as
a
potential
therapeutic
target
for
Nucleus,
Journal Year:
2022,
Volume and Issue:
13(1), P. 238 - 278
Published: Nov. 20, 2022
Access
to
DNA
is
a
prerequisite
the
execution
of
essential
cellular
processes
that
include
transcription,
replication,
chromosomal
segregation,
and
repair.
How
proteins
regulate
these
function
in
context
chromatin
its
dynamic
architectures
an
intensive
field
study.
Over
past
decade,
genome-wide
assays
new
imaging
approaches
have
enabled
greater
understanding
how
access
genome
regulated
by
nucleosomes
associated
proteins.
Additional
mechanisms
may
control
accessibility
vivo
compaction
phase
separation
–
are
beginning
be
understood.
Here,
we
review
ongoing
development
measurements,
summarize
different
molecular
structural
shape
landscape,
detail
many
important
biological
functions
linked
accessibility.
Theranostics,
Journal Year:
2023,
Volume and Issue:
13(6), P. 1774 - 1808
Published: Jan. 1, 2023
Metabolic
reprogramming
is
one
of
the
most
important
hallmarks
malignant
tumors.Specifically,
lipid
metabolic
has
marked
impacts
on
cancer
progression
and
therapeutic
response
by
remodeling
tumor
microenvironment
(TME).In
past
few
decades,
immunotherapy
revolutionized
treatment
landscape
for
advanced
cancers.Lipid
plays
pivotal
role
in
regulating
immune
to
immunotherapy.Here,
we
systematically
reviewed
characteristics,
mechanism,
cells
TME,
appraised
effects
various
cell
death
modes
(specifically
ferroptosis)
metabolism,
summarized
antitumor
therapies
targeting
metabolism.Overall,
profound
microenvironment;
therefore,
may
lead
development
innovative
clinical
applications
including
sensitizing
immunotherapy.
Cell Death and Disease,
Journal Year:
2023,
Volume and Issue:
14(2)
Published: Feb. 11, 2023
Abstract
Sepsis
is
a
life-threatening
disorder
disease
defined
as
infection-induced
dysregulated
immune
responses
and
multiple
organ
dysfunction.
The
imbalance
between
hyperinflammation
immunosuppression
crucial
feature
of
sepsis
immunity.
Epigenetic
modifications,
including
histone
DNA
methylation,
chromatin
remodeling,
non-coding
RNA,
play
essential
roles
in
regulating
immunity
through
epi-information
independent
the
sequence.
In
recent
years,
mechanisms
modification
have
received
increasing
attention,
with
ongoing
discoveries
novel
types
modifications.
Due
to
capacity
for
prolonged
effects
on
cells,
modifications
can
induce
cell
reprogramming
participate
long-term
immunosuppressed
state
sepsis.
Herein,
we
systematically
review
current
involved
regulation
sepsis,
summarize
their
role
from
an
perspective
provide
potential
therapeutic
opportunities
targeting
treatment.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(2), P. 824 - 824
Published: Jan. 9, 2024
Transcription
factors
are
pivotal
regulators
in
the
cellular
life
process.
Activating
transcription
factor
3
(ATF3),
a
member
of
ATF/CREB
(cAMP
response
element-binding
protein)
family,
plays
crucial
role
as
cells
respond
to
various
stresses
and
damage.
As
factor,
ATF3
significantly
influences
signal
transduction
regulation,
orchestrating
variety
signaling
pathways,
including
apoptosis,
ferroptosis,
differentiation.
In
addition,
serves
an
essential
link
between
inflammation,
oxidative
stress,
immune
responses.
This
review
summarizes
recent
advances
research
on
activation
its
regulating
inflammatory
responses,
cell
ferroptosis
while
exploring
dual
functions
these
processes.
Additionally,
this
article
discusses
diseases
related
pathogenic
microbial
infections.
Our
may
be
helpful
better
understand
responses
disease
progression,
thus
promoting
advancements
clinical
treatments
for
inflammation
stress-related
diseases.
Clinical Epigenetics,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: May 29, 2024
Abstract
Lactic
acid,
traditionally
considered
as
a
metabolic
waste
product
arising
from
glycolysis,
has
undergone
resurgence
in
scientific
interest
since
the
discovery
of
Warburg
effect
tumor
cells.
Numerous
studies
have
proved
that
lactic
acid
could
promote
angiogenesis
and
impair
function
immune
cells
within
microenvironments.
Nevertheless,
precise
molecular
mechanisms
governing
these
biological
functions
remain
inadequately
understood.
Recently,
been
found
to
induce
posttranslational
modification,
lactylation,
may
offer
insight
into
acid's
non-metabolic
functions.
Notably,
modification
proteins
by
lactylation
emerged
crucial
mechanism
which
lactate
regulates
cellular
processes.
This
article
provides
an
overview
acidification,
outlines
potential
“writers”
“erasers”
responsible
for
protein
presents
patterns
across
different
organisms,
discusses
diverse
physiological
roles
lactylation.
Besides,
highlights
latest
research
progress
concerning
regulatory
pathological
processes
underscores
its
significance
future
investigations.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(5), P. 2805 - 2838
Published: Feb. 19, 2024
Post-translational
modifications
(PTMs)
endow
proteins
with
new
properties
to
respond
environmental
changes
or
growth
needs.
With
the
development
of
advanced
proteomics
techniques,
hundreds
distinct
types
PTMs
have
been
observed
in
a
wide
range
from
bacteria,
archaea,
and
eukarya.
To
identify
roles
these
PTMs,
scientists
applied
various
approaches.
However,
high
dynamics,
low
stoichiometry,
crosstalk
between
make
it
almost
impossible
obtain
homogeneously
modified
for
characterization
site-specific
effect
individual
PTM
on
target
proteins.
solve
this
problem,
genetic
code
expansion
(GCE)
strategy
has
introduced
into
field
studies.
Instead
modifying
after
translation,
GCE
incorporates
amino
acids
during
thus
generating
site-specifically
at
positions.
In
review,
we
summarize
systems
orthogonal
translation
installation
PTMs.
