NAT10 promotes vascular remodelling via mRNA ac4C acetylation DOI
Yu Cheng, Yue Chen,

Hao Luo

et al.

European Heart Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Vascular smooth muscle cell (VSMC) phenotype switching is a pathological hallmark in various cardiovascular diseases. N4-acetylcytidine (ac4C) catalyzed by N-acetyltransferase 10 (NAT10) well conserved the enzymatic modification of ribonucleic acid (RNA). NAT10-mediated ac4C acetylation involved physiological and processes, including cardiac remodelling. However, biological functions underlying regulatory mechanisms mRNA modifications vascular diseases remain elusive.

Language: Английский

Metabolic Recoding of NSUN2‐Mediated m5C Modification Promotes the Progression of Colorectal Cancer via the NSUN2/YBX1/m5C‐ENO1 Positive Feedback Loop DOI Creative Commons
Baoxiang Chen,

Yanrong Deng,

Yuntian Hong

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(28)

Published: May 20, 2024

The RNA modification, 5-methylcytosine (m

Language: Английский

Citations

30
Persistent organic pollutant perfluorooctanoic acid induces alterations in epigenetic modifications of DNA and RNA DOI

Shu-Yi Gu,

Tian Feng,

Fang‐Yin Gang

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110957 - 110957

Published: Feb. 1, 2025

Language: Английский

Citations

4
Charting the epitranscriptomic landscape across RNA biotypes using native RNA nanopore sequencing DOI
Gregor Diensthuber, Eva Maria Novoa

Molecular Cell, Journal Year: 2025, Volume and Issue: 85(2), P. 276 - 289

Published: Jan. 1, 2025

Language: Английский

Citations

2
YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks DOI
Ning Tsao, Patrick M. Lombardi, Annie Park

et al.

Molecular Cell, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

2
RMBase v3.0: decode the landscape, mechanisms and functions of RNA modifications DOI Creative Commons

Jiajia Xuan,

Lifan Chen,

Zhirong Chen

et al.

Nucleic Acids Research, Journal Year: 2023, Volume and Issue: 52(D1), P. D273 - D284

Published: Nov. 13, 2023

Abstract Although over 170 chemical modifications have been identified, their prevalence, mechanism and function remain largely unknown. To enable integrated analysis of diverse RNA modification profiles, we developed RMBase v3.0 (http://bioinformaticsscience.cn/rmbase/), a comprehensive platform consisting eight modules. These modules facilitate the exploration transcriptome-wide landscape, biogenesis, interactome functions modifications. By mining thousands epitranscriptome datasets with novel pipelines, ‘RNA Modifications’ module reveals map 73 62 species. ‘Genes’ allows to retrieve profiles clusters by gene transcript. The ‘Mechanisms’ explores 23 382 enzyme-catalyzed or snoRNA-guided modified sites elucidate biogenesis mechanisms. ‘Co-localization’ systematically formulates potential correlations between 14 histone 6 in various cell-lines. ‘RMP’ investigates differential expression 146 RNA-modifying proteins (RMPs) 18 types cancers. ‘Interactome’ integrates interactional relationships RBP binding events, miRNA targets SNPs. ‘Motif’ illuminates enriched motifs for 11 identified from datasets. ‘Tools’ introduces web-based ‘modGeneTool’ annotating Overall, provides resources tools studying

Language: Английский

Citations

33
The competitive landscape of the dsRNA world DOI Creative Commons
Kyle A. Cottrell, Ryan J. Andrews, Brenda Bass

et al.

Molecular Cell, Journal Year: 2023, Volume and Issue: 84(1), P. 107 - 119

Published: Dec. 19, 2023

Language: Английский

Citations

33
mRNA nanodelivery systems: targeting strategies and administration routes DOI Creative Commons
Mujie Yuan, Zeyu Han, Yan Liang

et al.

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid (mRNA) vaccines, mRNA therapeutics have gained significant momentum for prevention and treatment various refractory diseases. To function efficiently in vivo overcome clinical limitations, demands safe stable vectors a reasonable administration route, bypassing multiple biological barriers achieving organ-specific targeted delivery mRNA. Nanoparticle (NP)-based systems representing leading vector approaches ensure successful intracellular to target organ. In this review, chemical modifications types advanced NPs, including lipid NPs polymers are summarized. The importance passive targeting, especially endogenous active targeting nano-delivery is emphasized, different cellular endocytic mechanisms discussed. Most importantly, based on above content physiological structure characteristics organs vivo, design strategies cells classified Furthermore, influence routes highlighted. Finally, an outlook remaining challenges future development toward therapies precision medicine provided.

Language: Английский

Citations

32
The functions and mechanisms of post-translational modification in protein regulators of RNA methylation: Current status and future perspectives DOI
Youming Chen,

Zuli Jiang,

Ying Yang

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 126773 - 126773

Published: Sept. 9, 2023

Language: Английский

Citations

23
RNA 5-methylcytosine writer NSUN5 promotes hepatocellular carcinoma cell proliferation via a ZBED3-dependent mechanism DOI Creative Commons
Xinyu Gu, Penghui Li, Xiaohui Gao

et al.

Oncogene, Journal Year: 2024, Volume and Issue: 43(9), P. 624 - 635

Published: Jan. 5, 2024

Abstract Hepatocellular carcinoma (HCC) is one of the leading contributors to cancer-related mortality worldwide. Nop2/Sun domain family member 5 (NSUN5), a conserved RNA 5-methylcytosine methyltransferase, conventionally recognized as oncogenic. However, its role in HCC development remains unknown. In this study, we observed remarkable upregulation NSUN5 expression both tumor tissues from patients with HCC, establishing correlation unfavorable clinical outcomes. knockdown and overexpression significantly inhibited promoted cell proliferation, respectively. Additionally, employing combination methylated immunoprecipitation sequencing (MeRIP-seq) RIP-seq techniques, identified zinc finger BED domain-containing protein 3 (ZBED3) novel downstream target NSUN5. found that ZBED3 counteracted tumor-suppressing effect simultaneously reversed inhibition Wnt/β-catenin signaling pathway. summary, elucidated oncogenic ZBED3/Wnt/β-catenin pathway target. This study provides therapeutic for further treatment.

Language: Английский

Citations

13
Degradation and translation of maternal mRNA for embryogenesis DOI Creative Commons
Guanghui Yang,

Qiliang Xin,

Jurrien Dean

et al.

Trends in Genetics, Journal Year: 2024, Volume and Issue: 40(3), P. 238 - 249

Published: Jan. 22, 2024

Language: Английский

Citations

13