Stem Cell Research & Therapy,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: July 2, 2024
Abstract
Over
the
past
decade,
we
have
witnessed
development
of
cell
transplantation
as
a
new
strategy
for
repairing
spinal
cord
injury
(SCI).
However,
due
to
complexity
central
nervous
system
(CNS),
achieving
successful
clinical
translation
remains
significant
challenge.
Human
umbilical
mesenchymal
stem
cells
(hUMSCs)
possess
distinct
advantages,
such
easy
collection,
lack
ethical
concerns,
high
self-renewal
ability,
multilineage
differentiation
potential,
and
immunomodulatory
properties.
hUMSCs
are
promising
regenerating
injured
extent.
At
same
time,
advancing
SCI
treatment,
appropriate
benefit
risk
evaluation
methods
play
pivotal
role
in
determining
applicability
treatment
plans.
Hence,
this
study
discusses
advantages
risks
across
four
dimensions—comprehensive
motor
sensory
function,
imaging,
electrophysiology,
autonomic
(ANS)
function—aiming
improve
rationality
relevant
research
feasibility
translation.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
The
"Voices"
under
this
Perspective
underline
the
importance
of
interdisciplinary
collaboration
and
partnerships
across
several
disciplines,
such
as
medical
science
technology,
medicine,
bioengineering,
computational
approaches,
in
bridging
gap
between
research,
manufacturing,
clinical
applications.
Effective
communication
is
key
to
team
gaps,
enhancing
trust,
resolving
conflicts,
thereby
fostering
teamwork
individual
growth
toward
shared
goals.
Drawing
from
success
COVID-19
vaccine
development,
we
advocate
application
similar
collaborative
models
other
complex
health
areas
nanomedicine
biomedical
engineering.
role
digital
technology
big
data
healthcare
innovation
highlighted
along
with
necessity
for
specialized
education
practices.
This
approach
decisive
advancing
solutions,
leading
improved
treatment
patient
outcomes.
Nephrology Dialysis Transplantation,
Journal Year:
2022,
Volume and Issue:
38(5), P. 1080 - 1088
Published: April 21, 2022
The
world
faces
a
dramatic
man-made
ecologic
disaster
and
healthcare
is
crucial
part
of
this
problem.
Compared
with
other
therapeutic
areas,
nephrology
care,
especially
dialysis,
creates
an
excessive
burden
via
water
consumption,
greenhouse
gas
emission
waste
production.
In
advocacy
article
from
the
European
Kidney
Health
Alliance
we
describe
mutual
impact
climate
change
on
kidney
health
care
ecology.
We
propose
array
measures
as
potential
solutions
related
to
prevention
disease,
transplantation
green
dialysis.
For
several
proactive
suggestions
are
made,
by
lowering
implementing
energy-neutral
policies,
triage
recycling
materials.
These
include
original
proposals
such
dialysate
regeneration,
flow
reduction,
distillation
systems
for
production,
heat
pumps
unit
climatization,
exchangers
warming,
biodegradable
bio-based
polymers,
alternative
power
sources,
repurposing
plastic
(e.g.
incorporation
in
concrete),
registration
platforms
exchange
best
practices.
also
discuss
how
Green
Deal
offers
real
supporting
galvanizing
these
urgent
environmental
changes.
Finally,
formulate
recommendations
professionals,
manufacturers,
providers
policymakers
correction
can
be
achieved.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(39)
Published: July 11, 2023
Acute
renal
allograft
rejection
(ARAR)
after
kidney
transplantation
associated
with
reduced
graft
survival
and
eventual
failure
is
poorly
diagnosed
in
hospitals.
Here,
we
report
the
development
of
Artificial
bioMarker
Probes
(AMPros)
for
sensitive
urinalysis
ARAR
murine
models.
AMPros
spontaneously
go
to
kidneys
systemic
administration,
specifically
react
prodromal
immune
biomarkers
activate
their
near-infrared
fluorescence
signals
cell-mediated
rejection,
efficiently
undergo
excretion
into
urine.
Thus,
enable
convenient
optical
that
detects
prior
histological
manifestation
which
also
earlier
than
current
diagnostic
methods
measuring
proinflammatory
cytokines
peripheral
blood
lymphocyte
mRNAs.
Due
high
specificity,
AMPros-based
discriminates
against
other
non-alloimmune
specific
diseases,
unattainable
by
measurement
serological
biomarkers.
Such
a
noninvasive
urine
test
holds
great
promise
continuous
monitoring
conditions
at
low
resource
settings
timely
clinical
interventions.
Frontiers in Digital Health,
Journal Year:
2024,
Volume and Issue:
6
Published: April 10, 2024
Addressing
disparities
in
living
kidney
donation
requires
making
information
accessible
across
literacy
levels,
especially
important
given
that
the
average
American
adult
reads
at
an
8th-grade
level.
This
study
evaluated
effectiveness
of
ChatGPT,
advanced
AI
language
model,
simplifying
to
reading
level
or
below.
National Science Review,
Journal Year:
2024,
Volume and Issue:
11(9)
Published: Aug. 10, 2024
ABSTRACT
Organ
injuries,
such
as
acute
kidney
injury,
ischemic
stroke,
and
spinal
cord
often
result
in
complications
that
can
be
life-threatening
or
even
fatal.
Recently,
many
nanomaterials
have
emerged
promising
agents
for
repairing
various
organ
injuries.
In
this
review,
we
present
the
important
developments
field
of
nanomaterial-based
repair
medicine,
herein
referred
to
‘nanorepair
medicine’.
We
first
introduce
disease
characteristics
associated
with
different
types
injuries
highlight
key
examples
relevant
nanorepair
medicine.
then
provide
a
summary
existing
strategies
including
organ-targeting
methodologies
potential
countermeasures
against
exogenous
endogenous
pathologic
risk
factors.
Finally,
offer
our
perspectives
on
current
challenges
future
expectations
advancement
nanomedicine
designed
injury
repair.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Enzyme-responsive,
multi-lock
optical
probes
exhibit
superior
detection
specificity
towards
certain
biomolecular
events
and
pathological
conditions,
offering
high
disease
diagnostic
accuracy
treatment
efficacy.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(28)
Published: May 8, 2024
Abstract
3D‐printed
cell‐laden
hydrogels
as
tissue
constructs
show
great
promise
in
generating
living
tissues
for
medicine.
Currently,
the
maturation
of
into
remains
challenge,
since
commonly
used
struggle
to
provide
an
ideal
microenvironment
seeded
cells.
In
this
study,
a
cell‐adaptable
nanocolloidal
hydrogel
is
created
3D
printing
maturable
constructs.
The
composed
interconnected
nanoparticles,
which
prepared
by
self‐assembly
and
subsequent
photocrosslinking
gelatin
methacryloyl
solutions.
Cells
can
get
enough
space
grow
migrate
within
through
squeezing
flexible
networks.
Meanwhile,
nanostructure
promote
cells
proliferate
produce
matrix
proteins
mechanotransduction.
Using
digital
light
process‐based
technology,
it
rapidly
customize
cartilage
After
implantation,
these
efficiently
matured
articular
defect
repair
ear
reconstruction
vivo.
using
shows
potential
future
clinical
applications.
BMC Nephrology,
Journal Year:
2025,
Volume and Issue:
26(1)
Published: Feb. 20, 2025
Despite
the
demonstrated
improved
patient
survival
and
financial
benefits
for
health
services
with
kidney
transplantation
compared
to
dialysis,
populations
outside
of
urban
areas
face
inequities
in
access
a
more
difficult
journey
than
their
metropolitan
counterparts.
This
study
aimed
explore
experiences
Australian
transplant
professionals
regarding
processes
patients
residing
regional,
rural,
remote
areas,
focus
on
improving
this
cohort.
Semi-structured
interviews
were
conducted
professionals.
Transcripts
analysed
thematically.
Interview
participants
(n
=
26)
consisted
primarily
nephrologists
from
transplanting
centres
(15%),
or
non-transplanting
(19%),
clinical
pharmacists
nursing
staff
(19%).
Six
main
themes
identified
barriers
transplantation,
including
ineffective
communication
education,
overwhelming
geographical
burden,
fighting
equal
opportunities,
paucity
social
support,
crushing
peril,
deprived
adequate
local
care.
Participants
also
made
recommendations
new
modified
service
delivery
models
address
barriers,
coordination
work-up
testing,
outreach
visits
assessment,
increased
earlier
provision
education.
Health
described
patient-specific
system
level
Australia
that
could
be
addressed
by
modification
current
implementation
