Organ and Tissue Donation Consent Model and Intent to Donate Registries: Recommendations From an International Consensus Forum

Transplantation Direct, Journal Year: 2023, Volume and Issue: 9(5), P. e1416 - e1416

Published: April 28, 2023

Consent model and intent to donate registries are often the most public facing aspects of an organ tissue donation transplantation (OTDT) system. This article describes output international consensus forum designed give guidance stakeholders considering reform these their

Language: Английский

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Inequities in Organ Donation and Transplantation Among Immigrant Populations in Italy: A Narrative Review of Evidence, Gaps in Research and Potential Areas for Intervention

Transplant International, Journal Year: 2023, Volume and Issue: 36

Published: Aug. 11, 2023

Immigrants from outside Europe have increased over the past two decades, especially in Southern European countries including Italy. This influx coincided with an number of immigrants end-stage organ diseases. In this narrative review, we reviewed evidence gaps between native-born and immigrant populations Organ Donation Transplantation (ODT) process Consistent prior studies, despite availability a publicly funded health system universal healthcare coverage, non-European-born individuals living Italy are less likely to receive donor kidney transplantation more inferior long-term graft function compared EU-born Eastern European-born individuals. While these patients increasingly represented among transplant recipients (especially liver transplants), refusal rates for donation higher some ethnic groups other foreign-born referents, potential downstream effects prolonged waiting times outcomes. process, identified relevant research biases existing studies. Given Italian National Transplant Center’s (CNT) commitment fighting inequities ODT, illustrated actions taken by CNT tackle ODT communities

Language: Английский

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Actioning the findings of hard endpoint clinical trials as they emerge in the realm of chronic kidney disease care: a review and a call to action

Clinical Kidney Journal, Journal Year: 2024, Volume and Issue: 17(2)

Published: Feb. 1, 2024

Fewer than half of patients treated with hemodialysis survive 5 years. Multiple therapeutics are used to address the complications advanced chronic kidney disease but most have not been found improve clinical outcomes. Clinical trials treatment innovations for diseases and dialysis care suboptimal in number quality. Recent changing this trend. Practice policy change when new evidence emerges remains frequently impeded by resource organizational constraints accordingly, practice guidelines updated years or decades after definitive is produced. Ultimately, health systems slow, leading impaired uptake effective medical interventions lower value healthcare, although rapid guideline production emerging. What can be done ensure that conclusive taken up practice, healthcare funding? We use example recently published hard endpoint study "Comparison high-dose HDF high-flux HD" (CONVINCE) (hemodiafiltration versus hemodialysis), explain how a trial impact on knowledge practices. (i) assess placed context totality evidence, (ii) define whether further convective therapies still needed (iii) examine now ready inform funding change. When looking at CONVINCE we show it addresses quality improvement priorities consistent other evaluating therapies, definitive. Once cost-effectiveness specific settings patient-reported outcomes become available, should therefore determine recommend routinely, move treatments.

Language: Английский

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Advancements in autologous peripheral nerve transplantation care: a review of strategies and practices to facilitate recovery

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: March 8, 2024

Autologous peripheral nerve transplantation, a pioneering technique in injury treatment, has demonstrated remarkable progress. We examine recent nursing strategies and methodologies tailored to various anatomical sites, highlighting their role postoperative recovery enhancement. Encompassing brachial plexus, upper limb, lower limb transplantation care, this discussion underscores the importance of personalized rehabilitation plans, interdisciplinary collaboration, innovative approaches like electrical stimulation growth factor therapy. Moreover, exploration extends effective complication management prevention strategies, encompassing infection control pain management. Ultimately, review concludes by emphasizing advances achieved autologous showcasing potential optimize through advanced practices.

Language: Английский

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Research progress and prospects of benefit-risk assessment methods for umbilical cord mesenchymal stem cell transplantation in the clinical treatment of spinal cord injury

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 2, 2024

Abstract Over the past decade, we have witnessed development of cell transplantation as a new strategy for repairing spinal cord injury (SCI). However, due to complexity central nervous system (CNS), achieving successful clinical translation remains significant challenge. Human umbilical mesenchymal stem cells (hUMSCs) possess distinct advantages, such easy collection, lack ethical concerns, high self-renewal ability, multilineage differentiation potential, and immunomodulatory properties. hUMSCs are promising regenerating injured extent. At same time, advancing SCI treatment, appropriate benefit risk evaluation methods play pivotal role in determining applicability treatment plans. Hence, this study discusses advantages risks across four dimensions—comprehensive motor sensory function, imaging, electrophysiology, autonomic (ANS) function—aiming improve rationality relevant research feasibility translation.

Language: Английский

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