Advances in Nutrition,
Journal Year:
2023,
Volume and Issue:
14(3), P. 555 - 569
Published: March 9, 2023
Kidney
stone
disease
(KSD)
(alternatively
nephrolithiasis
or
urolithiasis)
is
a
global
health
care
problem
that
affects
people
in
almost
all
of
developed
and
developing
countries.
Its
prevalence
has
been
continuously
increasing
with
high
recurrence
rate
after
removal.
Although
effective
therapeutic
modalities
are
available,
preventive
strategies
for
both
new
recurrent
stones
required
to
reduce
physical
financial
burdens
KSD.
To
prevent
kidney
formation,
its
etiology
risk
factors
should
be
first
considered.
Low
urine
output
dehydration
the
common
risks
types,
whereas
hypercalciuria,
hyperoxaluria,
hypocitraturia
major
calcium
stones.
In
this
article,
up-to-date
knowledge
on
(nutrition-based
mainly)
KSD
provided.
Important
roles
fluid
intake
(2.5–3.0
L/d),
diuresis
(>2.0–2.5
lifestyle
habit
modifications
(for
example,
maintain
normal
body
mass
index,
compensation
working
high-temperature
environment,
avoid
cigarette
smoking),
dietary
management
[for
sufficient
at
1000–1200
mg/d,
limit
sodium
2
3–5
g/d
chloride
(NaCl),
oxalate-rich
foods,
vitamin
C
D
supplements,
animal
proteins
0.8–1.0
g/kg
weight/d
but
increase
plant
patients
uric
acid
those
hyperuricosuria,
proportion
citrus
fruits,
consider
lime
powder
supplementation]
summarized.
Moreover,
uses
natural
bioactive
products
caffeine,
epigallocatechin
gallate,
diosmin),
medications
thiazides,
alkaline
citrate,
other
alkalinizing
agents,
allopurinol),
bacterial
eradication,
probiotics
also
discussed.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(6)
Published: Nov. 4, 2023
The
gut
microbiota
and
its
homeostasis
play
a
crucial
role
in
human
health.
However,
for
some
diseases
related
to
the
microbiota,
current
traditional
medicines
can
only
relieve
symptoms,
it
is
difficult
solve
root
causes
or
even
cause
side
effects
like
disturbances
microbiota.
Increasing
clinical
studies
evidences
have
demonstrated
that
probiotics,
prebiotics,
postbiotics
prevent
treat
various
diseases,
but
currently
they
be
used
as
dietary
supplements
rather
than
medicines,
which
restricts
application
of
probiotics
field
medicine.
Here,
this
review
analyzes
importance
health
problems
systematically
summarizes
effectiveness
mechanisms
maintaining
treating
based
on
animal
models
trials.
And
research
outcomes
development
trends
field,
challenges
prospects
their
health,
alleviating
are
analyzed.
It
hoped
promote
disease
treatment
open
up
new
frontiers
probiotic
research.
Journal of Affective Disorders,
Journal Year:
2023,
Volume and Issue:
329, P. 64 - 71
Published: Feb. 25, 2023
Several
studies
have
linked
gut
microbiota
to
human
brain
activity.
This
study
used
Mendelian
randomization
(MR)
investigate
the
causal
relationship
between
microbes
and
delirium.MR
was
select
SNPs
from
large-scale
GWAS
summary
data
on
211
taxa
delirium.
Inverse
variance
weighting
(IVW),
weighted
median,
MR-Egger
methods
were
for
statistical
analyses.
Outliers
assessed
using
leave-one-out
method.
To
avoid
horizontal
pleiotropy,
we
performed
MR-PRESSO
intercept
tests.
Cochran's
Q
I2
values
IVW
assess
heterogeneity.IVW
suggested
that
genetic
prediction
of
family
Desulfovibrionaceae
(1.784
(1.267-2.512),
P
=
0.001),
order
Desulfovibrionales
(1.501
(1.058-2.128),
0.023),
genus
Candidatus
Soleaferrea
(1.322
(1.052-1.659),
0.016)
increased
risk
delirium,
but
Oxalobacteraceae
(0.841
(0.722-0.981),
0.027),
genera
Holdemania
(0.766
(0.620-0.946),
0.013),
Ruminococcus
gnavus
(0.806
(0.661-0.982),
0.033),
Eggerthella
(0.815
(0.667-0.997),
0.047)
reduced
delirium.(1)
Limited
sample
size,
(2)
inability
interactions,
(3)
limited
European
populations.Our
results
suggest
presence
microbial
Desulfovibrionaceae,
Desulfovibrionales,
whereas
family,
Holdemania,
gnavus,
decreased
However,
potential
probiotic
interventions
in
prevention
perioperative
delirium
should
be
emphasized.
Foods,
Journal Year:
2023,
Volume and Issue:
12(17), P. 3201 - 3201
Published: Aug. 25, 2023
Oxalate
is
an
antinutrient
present
in
a
wide
range
of
foods,
with
plant
products,
especially
green
leafy
vegetables,
being
the
main
sources
dietary
oxalates.
This
compound
has
been
largely
associated
hyperoxaluria,
kidney
stone
formation,
and,
more
severe
cases,
systematic
oxalosis.
Due
to
its
impact
on
human
health,
it
extremely
important
control
amount
oxalate
particularly
for
patients
issues.
In
this
review,
summary
and
discussion
current
knowledge
analysis,
extraction
conditions,
specific
features
analytical
methods,
reported
occurrence
health
implications
are
presented.
addition,
brief
conclusion
further
perspectives
whether
high-oxalate
foods
truly
problematic
can
be
seen
as
threats
shown.
Journal of Cellular and Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
28(7)
Published: March 20, 2024
Kidney
stone,
one
of
the
oldest
known
diseases,
has
plagued
humans
for
centuries,
consistently
imposing
a
heavy
burden
on
patients
and
healthcare
systems
worldwide
due
to
their
high
incidence
recurrence
rates.
Advancements
in
endoscopy,
imaging,
genetics,
molecular
biology
bioinformatics
have
led
deeper
more
comprehensive
understanding
mechanism
behind
nephrolithiasis.
stone
formation
is
complex,
multi-step
long-term
process
involving
transformation
stone-forming
salts
from
free
ions
into
asymptomatic
or
symptomatic
stones
influenced
by
physical,
chemical
biological
factors.
Among
various
types
kidney
observed
clinical
practice,
calcareous
nephrolithiasis
currently
most
common
exhibits
intricate
mechanism.
Extensive
research
suggests
that
primarily
originates
interstitial
subepithelial
calcified
plaques
and/or
blockages
openings
collecting
ducts.
These
eventually
come
contact
with
urine
renal
pelvis,
serving
as
nidus
crystal
subsequent
growth.
Both
pathways
share
similar
mechanisms,
such
drive
abnormal
composition,
involvement
oxidative
stress
inflammation,
an
imbalance
inhibitors
promoters.
However,
they
also
possess
unique
characteristics.
Hence,
this
review
aims
provide
detailed
description
present
recent
discoveries
regarding
processes
two
distinct
birthplaces:
interstitium
tubule
lumen.
BMJ Open Ophthalmology,
Journal Year:
2024,
Volume and Issue:
9(1), P. e001547 - e001547
Published: Jan. 1, 2024
Evidence
from
observational
studies
has
reported
possible
associations
between
the
gut
microbiome
(GM)
and
glaucoma.
However,
causal
effect
of
GM
on
glaucoma
risk
remains
to
be
determined.
Food and Bioprocess Technology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
Abstract
Oxalic
acid
is
among
the
most
abundant
organic
acids
found
in
different
biospheres,
including
plants,
as
an
end
product
of
metabolism.
It
forms
either
soluble
or
insoluble
salts
with
monovalent
divalent
cations,
respectively.
Then,
consumption
oxalic
acid-rich
foods
human
diets,
particularly
leafy
vegetables
(e.g.,
spinach,
tea,
and
rhubarb),
affects
minerals
absorption
such
calcium.
Meanwhile,
its
high
level
blood
associated
many
diseases
hyperoxaluria
systemic
oxalosis
thus
classified
potential
anti-nutrients.
Various
factors
have
affected
levels
foods,
agricultural
traits
practices.
Hence,
current
review
aimed
at
rediscovering
dietary
sources,
metabolism,
various
processes
employed
to
reduce
content
consequently,
health
harmful
effects.
Among
them
are
physical/cooking,
chemical,
fermentation,
biotechnological
processing.
Recent
approaches
been
attempted
produce
transgenic
crops
remodeling
oxalate
degradation.
The
form
seems
be
better
absorbed
more
than
aiding
kidney
stones
formation.
Cooking
boiling,
microwaving,
steaming)
appears
a
useful
management
strategy
and,
therefore,
lowering
oxaluria.
present
provides
new
perspectives
on
processing
methods
lower
essential
highlighting
their
advantages
any
limitations
aid
improve
these
nutritional
value
consumption.
Gut Microbes,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 28, 2025
Hyperoxaluria,
including
primary
and
secondary
hyperoxaluria,
is
a
disorder
characterized
by
increased
urinary
oxalate
excretion
could
lead
to
recurrent
calcium
kidney
stones,
nephrocalcinosis
eventually
end
stage
renal
disease.
For
high
dietary
(HDOx)
or
its
precursors
intake
key
reason.
Recently,
accumulated
studies
highlight
the
important
role
of
gut
microbiota
in
regulation
homeostasis.
However,
underlying
mechanisms
involving
metabolite
disruptions
hyperoxaluria
remain
poorly
understood.
Here,
we
investigated
therapeutic
efficacy
fecal
transplantation
(FMT)
sourced
from
healthy
rats
fed
with
standard
pellet
diet
against
excretion,
damage
(CaOx)
crystal
depositions
via
using
rat
models.
We
observed
dose-dependent
increases
CaOx
due
accompanied
significant
reductions
diversity
shifts
Ruminococcaceae_UCG-014
Parasutterella
composition.
Metabolomic
analysis
validated
these
findings,
revealing
substantial
decreases
metabolites
associated
microbial
groups.
Transplanting
microbes
effectively
reduced
HDOx-induced
meanwhile
restoring
populations
their
metabolites.
Furthermore,
FMT
treatment
significantly
decrease
kidneys
via,
at
least
part,
upregulating
expressions
intestinal
barrier
proteins
transporters
intestine.
In
conclusion,
our
study
emphasizes
effectiveness
countering
related
These
findings
provide
insights
on
complex
connection
between
caused
microbiota,
offering
promising
avenues
for
targeted
strategies.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
10(12), P. 12375 - 12384
Published: March 24, 2025
Oxalate
decarboxylase
(OxDC)
from
Bacillus
subtilis
is
a
Mn-dependent
hexameric
enzyme
that
converts
oxalate
to
carbon
dioxide
and
formate.
Recently,
OxDC
has
attracted
the
interest
of
scientific
community
due
its
biotechnological
medical
applications
for
treatment
hyperoxaluria,
group
pathologic
conditions
associated
with
excessive
urinary
excretion
caused
by
either
increased
endogenous
production
or
exogenous
absorption.
The
fact
displays
optimum
pH
in
acidic
range
represents
big
limitation
most
involving
processes
occurring
at
neutral
pH,
where
activity
stability
are
remarkably
reduced.
Here,
through
bioinformatics-guided
protein
engineering
followed
combinatorial
mutagenesis
analyses
thermal
stability,
we
identified
double
mutant
endowed
enhanced
catalytic
efficiency
under
physiological
conditions.
obtained
engineered
form
offers
potential
tool
improved
intestinal
degradation
hyperoxaluria
patients.
