Human Immunology, Journal Year: 2024, Volume and Issue: 85(6), P. 111163 - 111163
Published: Oct. 24, 2024
Language: Английский
New England Journal of Medicine, Journal Year: 2024, Volume and Issue: 391(2), P. 122 - 132
Published: May 25, 2024
Antibody-mediated rejection is a leading cause of kidney-transplant failure. The targeting CD38 to inhibit graft injury caused by alloantibodies and natural killer (NK) cells may be therapeutic option.
Language: Английский
Citations
47
Immunity, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
2
Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1657 - 1678
Published: Feb. 1, 2025
Background: Associations between ulcerative colitis (UC) and ankylosing spondylitis (AS) have been reported in multiple studies, but the common etiologies of UC AS remain unknown. Thus, current study, we aimed to investigate shared genes relevant mechanisms AS. Methods: Using datasets for (GSE113079) (GSE1797879), initially identified differentially expressed (DEGs) through differential expression analysis. The DEGs from both were intersected identify DEGs, AS, which used receiver operating characteristic (ROC) curve analysis confirm key pathway. Gene set enrichment (GSEA) was obtain information on gene pathways interactions with or AS-related diseases, followed by immune infiltration Finally, peripheral blood samples verify mRNA eight using reverse transcription-polymerase chain reaction (RT-PCR). Results: Our results revealed that GMFG, GNG11, CLEC4D, CMTM2, VAMP5, S100A8, S100A12 DGKQ are potential diagnostic biomarkers UC. Rimegepant, eptinezumab, methotrexate, atogepant, ubrogepant as drugs S100A8 patients GSEA showed these associated antigen processing presentation, natural killer cell mediated cytotoxicity T receptor signaling pathway UC, significantly cells various immune-related pathways. Subsequent functional experiments significant increases expressions VAMP5 Additionally, CLEC4D notably higher than healthy controls. Conclusion: Key may improve understanding their relationship guide diagnosis treatment strategies. Keywords: colitis, spondylitis, diagnosis, etiology
Language: Английский
Citations
0
Expert Opinion on Investigational Drugs, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 10, 2025
Introduction Felzartamab is a novel, fully human CD38 monoclonal antibody, currently in development for the treatment of antibody-mediated rejection (AMR) following kidney transplantation.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 28, 2025
Osteopontin (OPN) is a multifunctional glycoprotein with various structural domains that enable it to perform diverse functions in both physiological and pathological states. This review comprehensively examines OPN from multiple perspectives, including its protein structure, interactions receptors, immune cells, roles kidney diseases transplantation. explores the immunological duality of significance value as biomarker therapeutic target In cancer, typically promotes tumor evasion by suppressing system. Conversely, immune-related diseases, particularly transplantation, activates system enhancing migration activation thereby exacerbating damage. may stem different splice variants exposure, after cleavage, domains, which play distinct biological cellular interactions. Additionally, has significant impact posttransplantation on chronic disease and, highlighting importance potential target. Future research should further explore specific mechanisms transplantation improve treatment strategies enhance patient quality life.
Language: Английский
Citations
0
Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)
Published: Feb. 11, 2025
Language: Английский
Citations
0
Clinical Transplantation, Journal Year: 2025, Volume and Issue: 39(2)
Published: Feb. 1, 2025
ABSTRACT Introduction This study investigated the impact of immunosuppressive drug concentrations on microvascular inflammation (MVI) in kidney transplant recipients with negative donor‐specific antibodies (DSA) against human leukocyte antigen (HLA) and C4d deposition peritubular capillaries. Methods We analyzed data from 268 living at Department Urology, University Osaka, Japan. Patients received therapy comprising extended‐release tacrolimus, mycophenolate mofetil (MMF), and/or everolimus, or without steroids. Graft biopsies were routinely performed 3, 12, 36 60 months post‐surgery. Results No significant differences observed between MVI+DSA‐C4d‐ MVI‐DSAC4d groups regarding graft survival rates (95.5% vs. 96.6%, p = 0.772) patient (95.7% 95.9%, 0.735). Lower tacrolimus everolimus significantly associated an increased risk (tacrolimus: OR, 0.169; 95% CI, 0.055–0.515; 0.002; everolimus: 0.386; 0.171–0.874; 0.022). In contrast, MPA concentration was not (OR, 0.994; 0.554–1.780; 0.984). Steroid discontinuation did 1.980; 0.318–12.000; 0.470). Conclusion trough levels correlated a higher incidence antibody‐independent MVI, supporting need for tailored regimens transplantation.
Language: Английский
Citations
0
Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 1559 - 1571
Published: Jan. 1, 2025
Language: Английский
Citations
0
Frontiers in Transplantation, Journal Year: 2025, Volume and Issue: 4
Published: April 15, 2025
Xenotransplantation offers an opportunity to radically change the availability of organs for life-saving human transplantation. Great progress has been made in porcine donor genetic engineering reduce immunogenicity pig and potentially enhance their resistance antibody-mediated rejection. There is also growing insight into more effective immune suppression regimens. These advances have improved duration cardiac xenograft survival non-human primates over last decade supported recent approval first-in-human clinical use hearts kidneys This review critically examines preclinical results xenotransplantation. We identify challenges that remain achieve consistent durable graft survival. discuss relative value primate decedent transplant models optimize patient cross-matching, suppression, postoperative monitoring,
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 17, 2025
Background Ischemic stroke, accounting for approximately 80% of all stroke cases, is a major public health challenge and leading cause death disability worldwide. Current treatments primarily involve thrombolytic therapy, limited to 4.5-hour window due the risk complications, underscoring need new therapeutic targets. Systemic inflammation plays critical role in progression, with immune cells infiltrating brain exacerbating damage. B cells, particular, have been implicated pathogenesis, although their exact remains contentious. This study examines anti-CD19 antibody (aCD19 Ab) treatment model determine if CD19 + cell depletion can reduce infarct size alleviate inflammation. Results investigated whether temporary inhibition B-cell activity using an aCD19 Ab could ischemic injury mouse by regulating cerebral systemic reactions. Mice subjected middle artery occlusion (MCAO) exhibited significant reductions edema, prolonged post-MCAO survival, improved behavioral outcomes following treatment. Transmission electron microscopy (TEM) Computed Tomography Angiography (CTA) results revealed reduction microvascular endothelial decreased mitochondrial damage neurons, reduced neuronal apoptosis, favorable reconstruction vascular network. Additionally, pro-inflammatory cytokines peripheral circulation. The response alterations observed MCAO/R group were consistent trends indicated patient data. Conclusions Temporary via injection alleviated suppressing Changes within meninges may play role, further investigation needed understand mechanisms involved. These findings suggest that responses contribute pathogenesis represent potential target therapy.
Language: Английский
Citations
0