Severe Combined Kidney Injury in an Hiv-Infected Patient Receiving Antiretroviral Therapy (Clinical Observation) DOI Creative Commons
Vetchinnikova On, В. П. Суслов,

Ya. A. Afanas’eva

et al.

The Russian Archives of Internal Medicine, Journal Year: 2024, Volume and Issue: 14(5), P. 394 - 400

Published: Oct. 14, 2024

Kidney injury in patients infected with the human immunodeficiency virus (HIV) has a diverse spectrum. Some antiretroviral therapy (ART) drugs have nephrotoxic effects. We present clinical case of severe combined kidney — chronic disease (CKD) and acute (AKD) patient HIV infection. She was on long-term treatment fixed-dose combination rilpivirine, tenofovir, emtricitabine had normal pre-treatment renal function (estimated glomerular filtration rate 69 mL/min/1.73m2 ). There gradual increase blood creatinine, but did not visit nephrologist ART changed. The admitted to nephrology department two years later because she arterial hypertension hyperazotemia (blood creatinine 718 μmol/l). Diagnosis: tubulointerstitial nephritis, CKD G5 taking into account during ART. treated peritoneal dialysis. persistent decrease stabilization (210-190 μmol/l was) which indicated AKD. presented observation demonstrates that an HIVinfected can lead development injury. HIV-infected receiving require regular monitoring follow-up by nephrologist.

Language: Английский

Tacrolimus toxicity management in a pregnant kidney transplant recipient with newly diagnosed human immunodeficiency virus: A case report DOI Creative Commons
Ahmad Matarneh,

Ravi Chokshi,

Sundus Sardar

et al.

SAGE Open Medical Case Reports, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 1, 2025

Managing kidney transplant recipients during pregnancy presents significant challenges, particularly in balancing the interactions and safety concerns of immunosuppressive medications such as mycophenolate mofetil tacrolimus. Pregnancy can affect tacrolimus levels, its profile remains underexplored. When patient also hasa human immunodeficiency virus, management becomes even more complicated due to potential between antiretrovirals immunosuppressants. Notably, is highly susceptible drug-drug interactions. Even minor adjustments active antiretroviral therapy result fluctuations potentially leading subtherapeutic concentrations (increasing risk rejection) or supratherapeutic levels with toxicity. Tacrolimus toxicity often managed by administering cytochrome P450 enzyme inducers, choice agent depending on factors degree induction. Agents isoniazid rifampicin are typically considered. In this case report, we described treatment a pregnant recipient newly diagnosed virus infection.

Language: Английский

Citations

1
Cardiac and Renal Comorbidities in Aging People Living With HIV DOI
Keir McCutcheon, Nolubabalo Unati Nqebelele, Lyle Murray

et al.

Circulation Research, Journal Year: 2024, Volume and Issue: 134(11), P. 1636 - 1660

Published: May 23, 2024

Contemporary World Health Organization data indicates that ≈39 million people are living with the human immunodeficiency virus. Of these, 24 have been reported to successfully accessed combination antiretroviral therapy. In 1996, endorsed widespread use of therapy, transforming virus infection from being a life-threatening disease chronic illness characterized by multiple comorbidities. The increased access therapy has translated (PLWH) no longer having reduced life expectancy. Although aging as biological process increases exposure oxidative stress and subsequent systemic inflammation, this effect is likely enhanced in PLWH they age. This narrative review engages intricate interplay between associated cardiac renal comorbidities development PLWH. We examine evolving demographic profile PLWH, emphasizing increasing prevalence individuals within population. A central focus discusses pathophysiological mechanisms underpin heightened susceptibility diseases

Language: Английский

Citations

8
New Therapies and Strategies to Curb HIV Infections with a Focus on Macrophages and Reservoirs DOI Creative Commons

Maria Marra,

Alessia Catalano, Maria Stefania Sinicropi

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(9), P. 1484 - 1484

Published: Sept. 18, 2024

More than 80 million people worldwide have been infected with the human immunodeficiency virus (HIV). There are now approximately 39 individuals living HIV/acquired syndrome (AIDS). Although treatments against HIV infection available, AIDS remains a serious disease. Combination antiretroviral therapy (cART), also known as highly active (HAART), consists of treatment combination several drugs that block multiple stages in replication cycle. However, increasing usage cART is inevitably associated emergence drug resistance. In addition, development persistent cellular reservoirs latent critical obstacle to viral eradication since rebound takes place once anti-retroviral (ART) interrupted. Thus, efforts being applied new generations drugs, vaccines and types cART. this review, we summarize antiviral therapies used for HIV/AIDS, both individual agents therapies, highlight role macrophages most recent clinical studies related

Language: Английский

Citations

5
The Role of Viral Infections in Acute Kidney Injury and Mesenchymal Stem Cell-Based Therapy DOI

Omer Qutaiba B Allela,

Nadine Ali, Gaurav Sanghvi

et al.

Stem Cell Reviews and Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский

Citations

0
Aging of adult lifetime survivors with perinatal HIV DOI
Indira Mallik, Merle Henderson, Sarah Fidler

et al.

Current Opinion in HIV and AIDS, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Purpose of review We describe the emerging clinical outcomes for adults born with perinatally acquired HIV (PHIV), who have been living throughout their life. Whilst many comorbidities appear similar to horizontally HIV, they manifest at a younger chronological age. The additional impact postnatal, childhood and adolescent growth development requires further consideration. Recent findings There is growing evidence an increased incidence metabolic, cardiovascular, respiratory, bone renal impairment as well structural brain changes associated impaired cognitive function, mental health disorders; early case series data suggests six-fold prevalence psychosis those lifelong compared age-matched peers. Older age, prior CDC-C diagnoses lower nadir CD4 count confer greatest risk PHIV complications in adulthood, but biological factors are compounded by socioeconomic deprivation, bereavement, HIV-associated stigma, discrimination immigration. aetiology these yet be fully elucidated includes systemic inflammation immune dysfunction despite suppressive antiretroviral therapy (ART). Summary Adults experience age viral suppression on ART. Exploring characterizing manifestations can best inform screening tools interventions that enhance quality life longevity.

Language: Английский

Citations

0
HIV-associated kidney disease: the changing spectrum and treatment priorities DOI
Nicola Wearne, Bianca Davidson

Current Opinion in Nephrology & Hypertension, Journal Year: 2024, Volume and Issue: 33(6), P. 603 - 612

Published: Aug. 19, 2024

This review examines the impact of HIV on kidney disease, which remains significant despite advances in antiretroviral therapy (ART). The is timely due to shifting epidemiology disease people with (PWH), driven by increased ART access, noncommunicable diseases, and region-specific opportunistic infections like tuberculosis.

Language: Английский

Citations

1
Severe Combined Kidney Injury in an Hiv-Infected Patient Receiving Antiretroviral Therapy (Clinical Observation) DOI Creative Commons
Vetchinnikova On, В. П. Суслов,

Ya. A. Afanas’eva

et al.

The Russian Archives of Internal Medicine, Journal Year: 2024, Volume and Issue: 14(5), P. 394 - 400

Published: Oct. 14, 2024

Kidney injury in patients infected with the human immunodeficiency virus (HIV) has a diverse spectrum. Some antiretroviral therapy (ART) drugs have nephrotoxic effects. We present clinical case of severe combined kidney — chronic disease (CKD) and acute (AKD) patient HIV infection. She was on long-term treatment fixed-dose combination rilpivirine, tenofovir, emtricitabine had normal pre-treatment renal function (estimated glomerular filtration rate 69 mL/min/1.73m2 ). There gradual increase blood creatinine, but did not visit nephrologist ART changed. The admitted to nephrology department two years later because she arterial hypertension hyperazotemia (blood creatinine 718 μmol/l). Diagnosis: tubulointerstitial nephritis, CKD G5 taking into account during ART. treated peritoneal dialysis. persistent decrease stabilization (210-190 μmol/l was) which indicated AKD. presented observation demonstrates that an HIVinfected can lead development injury. HIV-infected receiving require regular monitoring follow-up by nephrologist.

Language: Английский

Citations

1