Control of Mitochondrial Quality: A Promising Target for Diabetic Kidney Disease Treatment DOI Creative Commons
Q Li, Jin Shang, Reiko Inagi

et al.

Kidney International Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Pathological mechanisms of kidney disease in ageing DOI
Takeshi Yamamoto, Yoshitaka Isaka

Nature Reviews Nephrology, Journal Year: 2024, Volume and Issue: 20(9), P. 603 - 615

Published: July 18, 2024

Language: Английский

Citations

18
Recent advances in self-targeting natural product-based nanomedicines DOI Creative Commons

Haifan Liu,

Xingyue Jin, Suyi Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 20, 2025

Language: Английский

Citations

3
Dose-related effects of eugenol: exploring renal functionality and morphology in healthy Wistar rats DOI
Renner Philipe Rodrigues Carvalho,

Rosiany Vieira da Costa,

Isadora Ribeiro de Carvalho

et al.

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: 196, P. 115244 - 115244

Published: Jan. 8, 2025

Language: Английский

Citations

1
Danshen injection ameliorates unilateral ureteral obstruction-induced renal fibrosis by inhibiting ferroptosis via activating SIRT1/GPX4 pathway DOI Creative Commons
Yiwen Cao, Huan Zhao,

Shuyin Lin

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 13, 2025

The pathogenesis of renal fibrosis is related to blood stasis, and the method promoting circulation removing stasis often used as treatment principle. Danshen injection (DSI) a commonly drug for in clinic. However, whether DSI slows progression or potential mechanism uncertain. We investigated models using UUO mice TGF-β stimulation HK-2 cells. Our findings revealed that Fer-1 alleviated kidney injury by ameliorating morphology pathological vivo. Besides, inhibited vivo TGF-β-induced Furthermore, ferroptosis was lessened under treatment. More importantly, active ingredients (danshensu, salvianolic acid B, protocatechuic aldehyde, caffeic tanshinone IIA) could bind SIRT1. protein levels SIRT1 GPX4 were downregulated accompanied incremental concentrations Erastin, which repaired intervention. inhibition owing reversed inhibitor EX527. Taken together, our results indicated protect against attenuate activating SIRT1/GPX4 pathway. It expected be agent treat fibrosis.

Language: Английский

Citations

1
The Role of Mitochondrial Sirtuins (SIRT3, SIRT4 and SIRT5) in Renal Cell Metabolism: Implication for Kidney Diseases DOI Open Access
Florian Juszczak, Thierry Arnould, Anne‐Émilie Declèves

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6936 - 6936

Published: June 25, 2024

Kidney diseases, including chronic kidney disease (CKD), diabetic nephropathy, and acute injury (AKI), represent a significant global health burden. The kidneys are metabolically very active organs demanding large amount of ATP. They composed highly specialized cell types in the glomerulus subsequent tubular compartments which fine-tune metabolism to meet their numerous diverse functions. Defective renal metabolism, altered fatty acid oxidation or glycolysis, has been linked both AKI CKD. Mitochondria play vital role emerging research identified mitochondrial sirtuins (SIRT3, SIRT4 SIRT5) as key regulators metabolic adaptation, especially SIRT3. Sirtuins belong an evolutionarily conserved family mainly NAD

Language: Английский

Citations

5
Repurposing Mitochondria-Targeted Therapeutics for Kidney Diseases DOI
Austin Thompson, Sivasankaran Ponnusankar, Natalie E. Scholpa

et al.

Kidney International, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Role of SIRT7 in Prostate Cancer Progression: New Insight Into Potential Therapeutic Target DOI Creative Commons
Jiale Zhang,

Chenxin Liu,

Wenting Luo

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(7)

Published: April 1, 2025

ABSTRACT Prostate cancer (PCa) is the second most common in men worldwide, and understanding its molecular mechanisms crucial for developing effective treatment strategies. SIRT7, a NAD+‐dependent histone deacetylase, has emerged as key regulator PCa progression due to roles chromatin remodeling, DNA repair, transcriptional regulation. Analysis of 492 samples from The Cancer Genome Atlas (TCGA) via cBioPortal revealed that high SIRT7 expression associated with poor prognosis patients. Mechanistically, deacetylates H3 at lysine 18 (H3K18Ac), marker aggressive tumors, suppressing tumor suppressor genes promoting cell proliferation survival. Epithelial‐mesenchymal transition (EMT) cellular biological process which epithelial cells undergo specific morphological changes transform into characteristics mesenchymal cells. also regulates EMT, inhibiting lines reduces migration invasion, highlighting potential therapeutic target. In summary, clinical significance requires further research elucidate mechanisms. Developing inhibitors targeting SIRT7's deacetylase activity promising strategy. plays role regulating processes such proliferation, cycle, apoptosis through epigenetic control gene maintenance genomic stability. Therefore, may be target PCa, could have prognostic value patients, providing important guidance monitoring diagnosis by physicians.

Language: Английский

Citations

0
Unraveling Small Molecule-Mediated Sirtuin 3 Activation at a Distinct Binding Site for Cardioprotective Therapies DOI Creative Commons
Dan Zhang, Jifa Zhang,

Chengyong Wu

et al.

ACS Central Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Language: Английский

Citations

0
Ability of NAD and Sirt1 to epigenetically suppress albuminuria DOI Creative Commons
Kazuhiro Hasegawa, Masanori Tamaki, Eriko Shibata

et al.

Clinical and Experimental Nephrology, Journal Year: 2024, Volume and Issue: 28(7), P. 599 - 607

Published: April 8, 2024

Abstract The time for diabetic nephropathy (DN) to progress from mild severe is long. Thus, methods continuously repress DN are required exert long-lasting effects mediated through epigenetic regulation. In this study, we demonstrated the ability of nicotinamide adenine dinucleotide (NAD) and its metabolites reduce albuminuria Sirt1- or Nampt-dependent We previously reported that proximal tubular Sirt1 was lowered before glomerular Sirt1. Repressed found epigenetically elevate Claudin-1. addition, Nampt deficiency augmented TIMP-1 levels in Sirt6-mediated pathways, leading type-IV collagen deposition fibrosis. Altogether, propose Sirt1/Claudin-1 axis may be crucial onset at early stages Nampt/Sirt6/TIMP-1 promotes fibrosis middle late DN. Finally, administration NMN, an NAD precursor, potentiates regression maintain Claudin-1 podocytes, suggesting potential use as medications

Language: Английский

Citations

1
Sirtuin 3 in renal diseases and aging：from mechanisms to potential therapies DOI Creative Commons

Peng Xuan,

Haiqiang Ni,

Baicheng Kuang

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107261 - 107261

Published: June 23, 2024

The longevity protein sirtuins (SIRTs) belong to a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases. In mammals, SIRTs comprise seven members (SIRT1-7) which are localized different subcellular compartments. As the most prominent mitochondrial deacetylases, SIRT3 is known be regulated by various mechanisms and participate in virtually all aspects homeostasis metabolism, exerting significant impact on multiple organs. Notably, kidneys possess an abundance mitochondria that provide substantial energy for filtration reabsorption. A growing body evidence now supports involvement several renal diseases, including acute kidney injury, chronic disease, diabetic nephropathy; notably, these diseases associated with aging. this review, we summarize emerging role aging, highlights intricate exerts its effects. addition, highlight potential therapeutic significance modulating valuable insights into facilitate clinical application.

Language: Английский

Citations

1