Association between neutrophil-percentage-to-albumin ratio and diabetic kidney disease in type 2 diabetes mellitus patients: a cross-sectional study from NHANES 2009–2018

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 6, 2025

Background The neutrophil-percentage-to-albumin ratio (NPAR), as a low-cost and easily accessible inflammatory biomarker, has garnered considerable attention in various disease studies recent years. Specifically, existing research suggested significant correlation between NPAR diabetic retinopathy, indicating its potential relevance to complications. However, despite kidney (DKD) being complication that severely affects the quality of life patients, association prevalence DKD remains be elucidated. Therefore, this study aims explore link patients with type 2 diabetes mellitus. Methods We extracted complete data on neutrophil percentage, plasma albumin, serum creatinine, urine albumin-to-creatinine from National Health Nutrition Examination Survey database spanning 2009 2018. Multivariable logistic regression models were employed examine relationship levels DKD, conducted sensitivity tests, subsequently employing Generalized Additive Models combined smooth curve fitting methods relationships among variables. Then, subgroup analyses investigate changes across different subgroups. Finally, Receiver operating characteristic curves used assess predictive performance independent variable, NPAR, for dependent DKD. Results A total 2,263 participants enrolled cross-sectional study. After adjusting confounding factors, odds was 1.44 (95% CI: 1.08-1.90) second quartile group, 1.75 1.33-2.31) third 2.95 2.22-3.93) fourth group. Among mellitus, positive observed showed no differences populations. (ROC) analysis indicated had good Conclusion individuals T2DM. Additional large-scale prospective investigations may helpful corroborating these findings.

Language: Английский

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Increased HA/CD44/TGFβ signaling implicates in renal fibrosis of a Col4a5 mutant Alport mice

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: March 12, 2025

Abstract X-linked Alport syndrome (XLAS) caused by COL4A5 gene mutation is a hereditary disease that affects mainly the kidney. XLAS patients, especially males whose single copy of disrupted, suffer from life-threatening renal disease, mechanism which remains unclear. Renal fibrosis characteristic pathology observed in kidney tissue. However, molecular path loss-of-function to fibrotic largely unknown. On basis previously established mouse model, our study revealed an activated CD44-TGFβ signaling known strongly promote fibrosis, along with increased level low weight hyaluronan (LMW-HA) instead high (HMW-HA), activate CD44-dependent TGFβ tissues. Additionally, synthase 2 (HAS2), enzyme primarily responsible for HA production, was found be upregulated XLAS. In particular, vitro studies knockdown human kidney-derived HEK-293 cells can upregulate HAS2 at both RNA and protein levels. The novel contribution finding deficiency may lead overexpression accumulation signaling, thereby promoting possibly suggesting CD44 are potential therapeutic targets impeding

Language: Английский

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ACSL4 predicts rapid kidney function decline in patients with diabetic kidney disease

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 13, 2025

Background Ferroptosis of kidney tubular epithelial cells contributes to the pathogenesis diabetic disease (DKD). An increase in enzyme long-chain fatty acid CoA ligase 4 (ACSL4) favors ferroptosis. However, association between ACSL4 renal tubules and outcomes patients with DKD is unknown. Methods To investigate predictive property rapid function decline DKD, a retrospective cohort 72 biopsy-proven were enrolled followed up for median 23 months. Tubular expression levels biopsy specimens from 12 control subjects measured using immunohistochemistry staining. The associations level clinical characteristics as well defined an estimated glomerular filtration rate (eGFR) slope ≤ -5 ml/min/1.73m 2 /year analyzed. Results was mainly expressed cells. significantly higher than those subjects. positively correlated proteinuria negatively albumin hemoglobin at time biopsy. During follow-up period, eGFR these -2.30 /year. slope. top tertile baseline found identify who high risk similar significant relationship continuous variable. Conclusions associated progression may serve novel pathological biomarker.

Language: Английский

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Non-small Nanoprobes Based on FDA-approval Formulation for NIR-II Imaging and Detection of Drug-induced Acute Kidney Injury

Dyes and Pigments, Journal Year: 2024, Volume and Issue: unknown, P. 112598 - 112598

Published: Dec. 1, 2024

Language: Английский

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