Ultrasound technology and biomaterials for precise drug therapy

Materials Today, Journal Year: 2023, Volume and Issue: 63, P. 210 - 238

Published: Jan. 9, 2023

Language: Английский

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Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications

Science Advances, Journal Year: 2023, Volume and Issue: 9(24)

Published: June 14, 2023

Amino acid crystals are an attractive piezoelectric material as they have ultrahigh coefficient and appealing safety profile for medical implant applications. Unfortunately, solvent-cast films made from glycine brittle, quickly dissolve in body fluid, lack crystal orientation control, reducing the overall effect. Here, we present a processing strategy to create biodegradable, flexible, nanofibers of embedded inside polycaprolactone (PCL). The glycine-PCL nanofiber film exhibits stable performance with high ultrasound output 334 kPa [under 0.15 voltage root-mean-square (Vrms)], which outperforms state-of-the-art biodegradable transducers. We use this fabricate transducer facilitating delivery chemotherapeutic drug brain. device remarkably enhances animal survival time (twofold) mice-bearing orthotopic glioblastoma models. presented here could offer excellent platform not only therapy but also developing implantation fields.

Language: Английский

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Ultrasound-Triggered In Situ Photon Emission for Noninvasive Optogenetics

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(2), P. 1097 - 1107

Published: Jan. 6, 2023

Optogenetics has revolutionized neuroscience understanding by allowing spatiotemporal control over cell-type specific neurons in neural circuits. However, the sluggish development of noninvasive photon delivery brain limited clinical application optogenetics. Focused ultrasound (FUS)-derived mechanoluminescence emerged as a promising tool for situ emission, but there is not yet biocompatible liquid-phase system To achieve optogenetics with high temporal resolution and desirable biocompatibility, we have developed liposome (Lipo@IR780/L012) nanoparticles FUS-triggered delivery. Synchronized stable blue light emission was generated solution under FUS irradiation due to cascade reactions liposomes. In vitro tests revealed that Lipo@IR780/L012 could be triggered at different stimulation frequencies, resulting activation opsin-expressing spiking HEK cells irradiation. vivo optogenetic further demonstrated motor cortex noninvasively reversibly activated repetitive after intravenous injection lipid limb movements.

Language: Английский

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Ultrasound as a versatile tool for short- and long-term improvement and monitoring of brain function

Neuron, Journal Year: 2023, Volume and Issue: 111(8), P. 1174 - 1190

Published: March 13, 2023

Language: Английский

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Ultrasound Neuromodulation as a New Brain Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 10(14)

Published: March 24, 2023

Abstract Within the last decade, ultrasound has been “rediscovered” as a technique for brain therapies. Modern technologies allow focusing through human skull highly focal tissue ablation, clinical neuromodulatory stimulation, and targeted blood‐brain‐barrier opening. This article gives an overview on state‐of‐the‐art of most recent application: neuromodulation new therapy. Although research centers have existed decades, first treatment were not established until 2020, applications are spreading rapidly.

Language: Английский

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From concept to early clinical trials: 30 years of microbubble-based ultrasound-mediated drug delivery research

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 206, P. 115199 - 115199

Published: Feb. 5, 2024

Ultrasound mediated drug delivery, a promising therapeutic modality, has evolved remarkably over the past three decades. Initially designed to enhance contrast in ultrasound imaging, microbubbles have emerged as main vector for offering targeted therapy with minimized side effects. This review addresses historical progression of this technology, emphasizing pivotal role play augmenting extravasation and delivery. We explore complex mechanisms behind from stable inertial cavitation diverse acoustic phenomena, their applications medical fields. While potential delivery is undeniable, there are still challenges overcome. Balancing efficacy safety establishing standardized procedures essential areas requiring attention. A multidisciplinary approach, gathering collaborations between researchers, engineers, clinicians, important exploiting full technology. In summary, highlights using improving patient care across various conditions.

Language: Английский

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Strategies to Improve Drug Delivery Across the Blood–Brain Barrier for Glioblastoma

Current Neurology and Neuroscience Reports, Journal Year: 2024, Volume and Issue: 24(5), P. 123 - 139

Published: April 5, 2024

Abstract Purpose of Review Glioblastoma remains resistant to most conventional treatments. Despite scientific advances in the past three decades, there has been a dearth effective new New approaches drug delivery and clinical trial design are needed. Recent Findings We discuss how blood–brain barrier tumor microenvironment pose challenges for development therapies glioblastoma. Next, we treatments that aim overcome these barriers, including novel designs such as nanoparticles antibody–drug conjugates, methods delivery, convection-enhanced intra-arterial enhance penetration, disruption by focused ultrasound laser interstitial thermal therapy. Lastly, address future opportunities, positing combination therapy best strategy treatment, neoadjuvant window-of-opportunity simultaneously therapeutic effectiveness with interrogation on-treatment biologic endpoints, adaptive platform basket trials imperative design. Summary GBM treatment should account blood-brain immunosuppression improving combining treatments, integrating designs.

Language: Английский

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Focused ultrasound-assisted delivery of immunomodulating agents in brain cancer

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 283 - 299

Published: Jan. 29, 2024

Language: Английский

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Low-intensity focused ultrasound to the human dorsal anterior cingulate attenuates acute pain perception and autonomic responses.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. e1011232023 - e1011232023

Published: Jan. 5, 2024

The dorsal anterior cingulate cortex (dACC) is a critical brain area for pain and autonomic processing, making it promising non-invasive therapeutic target. We leverage the high spatial resolution deep focal lengths of low-intensity focused ultrasound (LIFU) to non-invasively modulate dACC effects on behavioral cardiac responses using transient heat stimuli. N = 16 healthy human volunteers (6M/10F) received contact during either LIFU or Sham stimulation. Continuous electroencephalogram (EEG), electrocardiogram (ECG), electrodermal response (EDR) were recorded. Outcome measures included ratings, heart-rate variability, EDR response, blood pressure, amplitude heat-evoked potential (CHEP). reduced ratings by 1.09 ± 0.20 points relative Sham. increased heart rate variability indexed standard deviation normal sinus beats (SDNN), low frequency (LF) power, low-frequency/high-frequency (LF/HF) ratio. There no pressure EDR. resulted in 38.1% reduction P2 CHEP amplitude. Results demonstrate reduces alters acute This has implications causal understanding processing future options relief modulation homeostatic signals. Significance Statement New lines inquiry signals like (HRV) are aberrant chronic mental health disorders, which may contribute their underlying etiology. key center with direct influences function, but its depth precludes access without invasive surgery. For first time humans, we can selectively reduce perception, responses, work further establishes role clinical applications neuropsychological populations.

Language: Английский

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A practical guide to transcranial ultrasonic stimulation from the IFCN-endorsed ITRUSST consortium

Clinical Neurophysiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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