Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(5), P. 901 - 912
Published: March 21, 2024
Language: Английский
Neurology Neuroimmunology & Neuroinflammation, Journal Year: 2022, Volume and Issue: 10(1)
Published: Nov. 22, 2022
Many challenges exist in the precise diagnosis and clinical management of secondary progressive multiple sclerosis (SPMS) because lack definitive clinical, imaging, immunologic, or pathologic criteria that demarcate transition from relapsing-remitting MS to SPMS. This review provides an overview diagnostic criteria/definition heterogeneity associated with different SPMS patient populations; it also emphasizes importance available prospective/retrospective tools identify patients earlier disease course so approved disease-modifying therapies nonpharmacological strategies will translate into better outcomes. Delivery such interventions necessitates evolving patient-clinician dialog within context a multidisciplinary team.
Language: Английский
Citations
40
The Lancet Neurology, Journal Year: 2023, Volume and Issue: 23(1), P. 95 - 109
Published: Dec. 13, 2023
Language: Английский
Citations
32
Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(25), P. 4725 - 4737
Published: May 19, 2023
Aging is a significant risk factor associated with the progression of CNS neurodegenerative diseases including multiple sclerosis (MS). Microglia, resident macrophages parenchyma, are major population immune cells that accumulate in MS lesions. While they normally regulate tissue homeostasis and facilitate clearance neurotoxic molecules oxidized phosphatidylcholines (OxPCs), their transcriptome neuroprotective functions reprogrammed by aging. Thus, determining factors instigate aging microglia dysfunction can lead to new insights for promoting repair halting disease progression. Through single-cell RNA sequencing (scRNAseq), we identified Lgals3, which encodes galectin-3 (Gal3), as an age upregulated gene responding OxPC. Consistently, excess Gal3 accumulated OxPC lysolecithin-induced focal spinal cord white matter (SCWM) lesions middle-aged mice compared young mice. was also elevated mouse experimental autoimmune encephalomyelitis (EAE) more importantly brain from two male one female individuals. delivery alone into did not induce damage, its co-delivery increased cleaved caspase 3 IL-1β within exacerbated OxPC-induced injury. Conversely, OxPC-mediated neurodegeneration reduced Gal3-/- Gal3+/+ neuroinflammation overexpression microglia/macrophages may be detrimental CNS.SIGNIFICANCE STATEMENT accelerates such Understanding molecular mechanisms increases susceptibility damage could strategies manage Here, highlight microglia/macrophage-associated (Gal3) More importantly, co-injection lipids found lesions, caused greater injection alone, whereas genetic loss damage. These results demonstrate suggest deposition contribute neurodegeneration.
Language: Английский
Citations
24
Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14
Published: June 9, 2023
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease that commonly results in nontraumatic disability young adults. The characteristic pathological hallmark of MS damage to myelin, oligodendrocytes, axons. Microglia provide continuous surveillance the CNS microenvironment initiate defensive mechanisms protect tissue. Additionally, microglia participate neurogenesis, synaptic refinement, myelin pruning through expression release different signaling factors. Continuous activation has been implicated disorders. We first review lifetime microglia, including origin, differentiation, development, function microglia. then discuss whole processes remyelination demyelination, microglial phenotypes MS, NF-κB/PI3K-AKT pathway regulatory pathways may change homeostasis which would accelerate progression MS.
Language: Английский
Citations
23
Current Opinion in Neurology, Journal Year: 2024, Volume and Issue: 37(3), P. 189 - 201
Published: March 27, 2024
Research in multiple sclerosis (MS) has long been predicated on clinical groupings that do not reflect the underlying biologic heterogeneity apparent within patient populations. This review explicates various levels of explanation through which spectrum disease is described and investigated both above below threshold detection, as framed by topographical model MS, to help advance a cogent mechanistic framework.
Language: Английский
Citations
13
Expert Review of Neurotherapeutics, Journal Year: 2024, Volume and Issue: 24(2), P. 201 - 216
Published: Jan. 18, 2024
Introduction While magnetic resonance imaging (MRI) is established in diagnosing and monitoring disease activity multiple sclerosis (MS), its utility predicting progression less clear.
Language: Английский
Citations
11
Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1232 - 1232
Published: April 20, 2024
L-carnitine (LC), a vital nutritional supplement, plays crucial role in myocardial health and exhibits significant cardioprotective effects. LC, being the principal constituent of clinical-grade supplements, finds extensive application recovery treatment diverse cardiovascular cerebrovascular disorders. However, controversies persist regarding utilization LC nervous system diseases, with varying effects observed across numerous mental neurological This article primarily aims to gather analyze database information comprehensively summarize therapeutic potential patients suffering from diseases while providing valuable references for further research.
Language: Английский
Citations
11
Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(2)
Published: Feb. 1, 2025
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 17, 2025
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory and neurodegenerative disease affecting the central nervous system (CNS). MS associated with complex interplay between processes, mostly attributed to pathogenic T B cells. However, growing body of preclinical clinical evidence indicates that innate immunity plays crucial role in promotion progression. Accordingly, studies targeting different immune cells control are currently under study, highlighting importance this pathology. Here, we reviewed recent findings regarding played by pathogenesis MS. Additionally, discuss potential new treatments for based on targets against components.
Language: Английский
Citations
1
Current Opinion in Neurology, Journal Year: 2022, Volume and Issue: 35(3), P. 299 - 306
Published: June 1, 2022
Purpose of review Microglia normally protects the central nervous system (CNS) against insults. However, their persistent activation in multiple sclerosis (MS) contributes to injury. Here, we microglia MS and detection using positron emission tomography (PET). Recent findings During lesion evolution progression MS, activity may contribute neurotoxicity through release pro-inflammatory cytokines, reactive oxidative species, proteases glutamate. A means detect monitor individuals living with is provided by (PET) imaging mitochondrial 18-kDa translocator protein (TSPO) ligand. TSPO PET shows increased microglial within normal appearing white matter that precedes radiological signs neurodegeneration measured T2 enlargement. PET-detected increases MS. These demand use CNS penetrant inhibitors affect microglia. Such therapies include hydroxychloroquine recently reported a small study reduce expected primary progressive Bruton's tyrosine kinase for which there are now eleven Phase 3 registered trials Summary Microglial drives injury microglia-specific ligands offer new insights into as treatment responses.
Language: Английский
Citations
35