Natural products for the treatment of chemotherapy-related cognitive impairment and prospects of nose-to-brain drug delivery DOI Creative Commons
Yuqiong He, Cancan Zhou,

Shenggui Jiang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 29, 2024

Chemotherapy-related cognitive deficits (CRCI) as one of the common adverse drug reactions during chemotherapy that manifest memory, attention, and executive function impairments. However, there are still no effective pharmacological therapies for treatment CRCI. Natural compounds have always inspired development numerous natural products shown potential therapeutic effects on Nevertheless, improving brain targeting in CRCI is a problem to be overcome at present future. Accumulated evidence shows nose-to-brain delivery may an excellent carrier compounds. Therefore, we reviewed with anti-CRCI, focusing signaling pathway these drugs’ anti-CRCI effects, well possibility prospect treating based In conclusion, this review provides new insights further explore

Language: Английский

Cognitive impairment after cancer treatment: mechanisms, clinical characterization, and management DOI

Ben Fleming,

Paul Edison, Laura Kenny

et al.

BMJ, Journal Year: 2023, Volume and Issue: unknown, P. e071726 - e071726

Published: March 15, 2023

Abstract Cognitive impairment is a debilitating side effect experienced by patients with cancer treated systemically administered anticancer therapies. With around 19.3 million new cases of worldwide in 2020 and the five year survival rate growing from 50% 1970 to 67% 2013, an urgent need exists understand enduring effects severe implications for quality life. Whereas cognitive associated chemotherapy recognized breast cancer, researchers have started identify other treatments such as immune, endocrine, targeted therapies only recently. The underlying mechanisms are diverse therapy specific, so further evaluation needed develop effective therapeutic interventions. Drug non-drug management strategies emerging that target mechanistic pathways or deficits themselves, but they be rigorously evaluated. Clinically, consistent use objective diagnostic tools necessary accurate diagnosis clinical characterization This should supplemented guidelines could implemented daily practice. review summarizes recent advances mechanisms, characterization, novel treatment non-central nervous system cancers.

Language: Английский

Citations

43
Concentrations of S100B and neurofilament light chain in blood as biomarkers for checkpoint inhibitor–induced CNS inflammation DOI Creative Commons
Sara Bjursten, Zhiyuan Zhao,

Hifaa Al Remawi

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 100, P. 104955 - 104955

Published: Jan. 3, 2024

Cancer treatment with immune checkpoint inhibition (ICI) can cause immune-related adverse events in the central nervous system (CNS irAE). There are no blood biomarkers to detect CNS irAE. We investigated if concentrations of S100-calcium-binding protein B (S100B) and neurofilament light chain (NfL) be used as for irAE assessed incidence a cohort ICI-treated patients.

Language: Английский

Citations

15
Recent advances in 3D bioprinting for cancer research: From precision models to personalized therapies DOI

Ruchika,

Neha Bhardwaj, Sudesh Kumar Yadav

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(4), P. 103924 - 103924

Published: Feb. 22, 2024

Language: Английский

Citations

10
Targeted delivery and controlled release of polymeric nanomedicines for tumor therapy DOI Creative Commons
Na Shen, Weidong Zhao,

Hongyu Chu

et al.

Fundamental Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
CJ2: A Novel Potent Platinum(IV) Prodrug Enhances Chemo-Immunotherapy by Facilitating PD-L1 Degradation in the Cytoplasm and Cytomembrane DOI

Renming Fan,

Aohua Deng,

Bing Qi

et al.

Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 66(1), P. 875 - 889

Published: Jan. 3, 2023

Platinum drugs as primary chemotherapy have been applied to various cancer patients. However, their therapeutic applicability is limited due the adverse effects and immunosuppression. To minimize side boost immune response, we designed synthesized platinum(IV) prodrugs that introduced BRD4 inhibitor JQ-1. Among them, CJ2 had most potent activity less toxicity. With introduction of ligand JQ-1, CJ2-reduced PD-L1 protein was found in cytoplasm cytomembrane for first time. By interfering with synthesis, could arouse system promote CD8+ T cell infiltration. Meanwhile, accelerate degradation block DNA damage repair. In vivo, markedly suppressed tumor growth by reversing immunosuppression microenvironment enhancing damage. These findings provide an effective approach improve selectivity platinum elevated response.

Language: Английский

Citations

21
Cognitive impairment following breast cancer treatments: an umbrella review DOI Creative Commons
Giulia Oliva, Andreina Giustiniani, Laura Danesin

et al.

The Oncologist, Journal Year: 2024, Volume and Issue: 29(7), P. e848 - e863

Published: May 9, 2024

Cancer-related cognitive impairment (CRCI) refers to a decline associated with cancer or its treatments. While research into CRCI is expanding, evidence remains scattered due differences in study designs, methodologies, and definitions. The present umbrella review aims provide comprehensive overview of the current regarding impact different breast therapies on functioning, particular focus interplay among objective deficits (ie, measured standardized tests), subjective concerns, self-reported), other mediating psycho-physical factors.

Language: Английский

Citations

8
Elevated C-Reactive Protein and Subsequent Patient-Reported Cognitive Problems in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study DOI
Judith Carroll, Zev M. Nakamura, Brent J. Small

et al.

Journal of Clinical Oncology, Journal Year: 2022, Volume and Issue: 41(2), P. 295 - 306

Published: Sept. 30, 2022

To examine longitudinal relationships between levels of C-reactive protein (CRP) and cognition in older breast cancer survivors noncancer controls.

Language: Английский

Citations

25
Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring DOI Creative Commons

Kiho Kim,

In Sik Min, Tae Hee Kim

et al.

npj Flexible Electronics, Journal Year: 2023, Volume and Issue: 7(1)

Published: Aug. 28, 2023

Abstract Photodynamic therapy (PDT) is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues, exhibit fewer side effects, and lack pain during treatments. Implantable PDT systems have recently been developed to resolve the issues of bulky expensive conventional implement continuous repetitive treatment. Existing implantable systems, however, are not able perform multiple functions simultaneously, such modulating light intensity, measuring, transmitting tumor-related data, resulting in complexity Here, we introduce flexible fully wireless optoelectronic system capable effective by fusing hyperthermia enabling tumor size monitoring real-time. This exploits micro inorganic light-emitting diodes (μ-LED) emit with wavelength 624 nm, designed affect surrounding normal tissues utilizing programmable intensity μ-LED precisely Si phototransistor long-term implantation (2–3 weeks). The superiority simultaneous capabilities our operated power data transmissions cell phone was confirmed through vitro experiments, ray-tracing simulation results, xenograft mouse model vivo. all-in-one single for offers opportunities only enable tumors located deep tissue but also precise

Language: Английский

Citations

13
Neurological Complications of Conventional and Novel Anticancer Treatments DOI Open Access
Paola Alberti, Alessandro Salvalaggio, Andreas A. Argyriou

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(24), P. 6088 - 6088

Published: Dec. 10, 2022

Various neurological complications, affecting both the central and peripheral nervous system, can frequently be experienced by cancer survivors after exposure to conventional chemotherapy, but also modern immunotherapy. In this review, we provide an overview of most well-known adverse events related with a focus on chemotherapy induced neurotoxicity, address some emerging novel clinical entities treatment, including chemotherapy-related cognitive impairment immune-mediated events. Unfortunately, efficacious curative or preventive treatment for all these complications is still lacking. We description possible mechanisms involved drive future drug discovery in field, symptomatic neuroprotection.

Language: Английский

Citations

21
A systematic review of rehabilitation programs for cognitive impairment related to breast cancer: Different programs at different times? DOI Creative Commons

Marianne Merceur,

Karen T. Reilly,

I. Bonan

et al.

Annals of Physical and Rehabilitation Medicine, Journal Year: 2024, Volume and Issue: 67(5), P. 101832 - 101832

Published: March 26, 2024

"Cancer Related Cognitive Impairment" (CRCI) defines cognitive disorders related to cancer and its treatments. Many people with breast experience signs of CRCI (incidence between 20 30 %) and, although several intervention options exist, there is no established standard care. Our main objective was provide a detailed description the methods results randomized controlled trials interventions for in survivors, paying particular attention timing within care pathway. We conducted systematic literature review following PRISMA guidelines from 01 01–2019 16–07–2023 included after at least one assessment as primary or secondary outcome. Among 228 identified studies, 35 (including 2821 participants) were retained inclusion. The classified into 4 categories: rehabilitation, physical activity, complementary therapy pharmacological treatment. analysis revealed that have effect, whereas activity proposed months initial treatment improve Quality Life Speed Information Processing while later Memory Attention (Cognitive Rehabilitation) Perceived Function Depression/Anxiety/Mood (Complementary Therapies). multifactorial affected individuals frequently high levels fatigue, pain, anxiety depression are most likely benefit holistic approaches include cognition, relaxation, psychoeducation, group support and/or psychological counselling. Thus, rehabilitation programs should be designed on multi-modal approaches, using innovative, cost-effective delivery increase access treatment, outcomes evaluated measures participation. recorded Prospero (01–03–2020), registration number 135,627.

Language: Английский

Citations

4