Cerebellum in neurodegenerative diseases: advances, challenges, and prospects DOI Creative Commons
Guangdong Liu, Cui Yang, Xin Wang

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(11), P. 111194 - 111194

Published: Oct. 18, 2024

Neurodegenerative diseases (NDs) are a group of neurological disorders characterized by the progressive dysfunction neurons and glial cells, leading to their structural functional degradation in central and/or peripheral nervous system. Historically, research on NDs has primarily focused brain, brain stem, or spinal cord associated with disease-related symptoms, often overlooking role cerebellum. However, an increasing body clinical biological evidence suggests significant connection between cerebellum NDs. In several NDs, cerebellar pathology biochemical changes may start early disease stages. This article provides comprehensive update involvement features pathogenesis multiple suggesting that is involved onset progression through various mechanisms, including specific neurodegeneration, neuroinflammation, abnormal mitochondrial function, altered metabolism. Additionally, this review highlights therapeutic potential cerebellum-related treatments for

Language: Английский

Targeting modulation of intestinal flora through oral route by an antimicrobial nucleic acid-loaded exosome-like nanovesicles to improve Parkinson’s disease DOI
Weitong Cui, Zhiyong Guo, Xingyu Chen

et al.

Science Bulletin, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

17
Cerebellum in Alzheimer's disease and other neurodegenerative diseases: an emerging research frontier DOI Creative Commons
Cui Yang, Guangdong Liu, Xi Chen

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(7)

Published: July 1, 2024

Abstract The cerebellum is crucial for both motor and nonmotor functions. Alzheimer's disease (AD), alongside other dementias such as vascular dementia (VaD), Lewy body (DLB), frontotemporal (FTD), well neurodegenerative diseases (NDs) like Parkinson's (PD), amyotrophic lateral sclerosis (ALS), Huntington's (HD), spinocerebellar ataxias (SCA), are characterized by specific non‐specific neurodegenerations in central nervous system. Previously, the cerebellum's significance these conditions was underestimated. However, advancing research has elevated its profile a critical node pathology. We comprehensively review existing evidence to elucidate relationship between aforementioned diseases. Our findings reveal growing of unequivocally establishing link AD, forms dementia, NDs, supported clinical evidence, pathological biochemical profiles, structural functional neuroimaging data, electrophysiological findings. By contrasting cerebellar observations with those from cerebral cortex hippocampus, we highlight distinct role processes. Furthermore, also explore emerging therapeutic potential targeting treatment This underscores importance diseases, offering new insights into mechanisms novel strategies.

Language: Английский

Citations

12
Anatomical Abnormalities Suggest a Compensatory Role of the Cerebellum in Early Parkinson's Disease DOI Creative Commons

Juyoung Jenna Yun,

Anastasia Gailly de Taurines,

Yen Tai

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: 310, P. 121121 - 121121

Published: March 5, 2025

Brain atrophy is detected in early Parkinson's disease (PD) and accelerates over the first few years post-diagnosis. This was captured by multiple cross-sectional studies a longitudinal PD. Yet only study with control group can capture accelerated PD differentiate it from healthy ageing. Accordingly, we performed multicohort analysis between ageing, examining subcortical regions implicated pathology, including basal ganglia, thalamus, corpus callosum (CC), cerebellum. Longitudinal volumetric on 56 patients 53 matched controls, scans collected 2-3 apart. At baseline, showed greater volume pallidum, cerebellar white matter (WM), suggesting potential compensatory mechanisms prodromal After years, observed putamen WM. Interestingly, controls - but not demonstrated significant decline Total Intracranial Volume (TIV), thalamus mid-CC. Between-group revealed more severe right striatum WM PD, mid-posterior CC controls. Using CEREbellum Segmentation (CERES) for lobule segmentation cohort, found of non-motor cerebellum, specifically Crus I IX. Our results highlight an initial increase during followed degeneration

Language: Английский

Citations

1
Imbalance and gait impairment in Parkinson’s disease: discussing postural instability and ataxia DOI
Carlos Henrique Ferreira Camargo,

Silvia Aparecida Ferreira-Peruzzo,

Danieli Isabel Romanovitch Ribas

et al.

Neurological Sciences, Journal Year: 2023, Volume and Issue: 45(4), P. 1377 - 1388

Published: Nov. 21, 2023

Language: Английский

Citations

14
Integrated cerebellar radiomic‐network model for predicting mild cognitive impairment in Alzheimer's disease DOI Creative Commons

Yini Chen,

Yiwei Qi,

Yiying Hu

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 21(1)

Published: Nov. 13, 2024

Pathological and neuroimaging alterations in the cerebellum of Alzheimer's disease (AD) patients have been documented. However, role cerebellum-derived radiomic structural connectome modeling prediction AD progression remains unclear. Radiomic features were extracted from magnetic resonance imaging (MRI) Disease Neuroimaging Initiative (ADNI) dataset (n = 1319) an in-house 308). Integrated machine learning models developed to predict conversion risk normal cognition (NC) mild cognitive impairment (MCI) over a 6-year follow-up. The cerebellar outperformed hippocampal distinguishing MCI NC predicting transitions across both cohorts. Key predictors included textural right III left I II lobules, network properties Vermis II, which associated with decline AD. Cerebellum-derived radiomic-network shows promise as tool for early identification during preclinical stage Altered topological networks identified subjects (MCI). integrated cognition. model effectively predicts can stratify individuals into distinct categories. Specific are various stages amyloid beta tau pathology.

Language: Английский

Citations

6
A model with dopamine depletion in basal ganglia and cerebellum predicts changes in thalamocortical beta oscillations DOI
Benedetta Gambosi, Francesco Jamal Sheiban, Marco Biasizzo

et al.

International Journal of Neural Systems, Journal Year: 2024, Volume and Issue: 34(09)

Published: May 10, 2024

Parkinsonism is presented as a motor syndrome characterized by rigidity, tremors, and bradykinesia, with Parkinson's disease (PD) being the predominant cause. The discovery that those symptoms result from death of dopaminergic cells in substantia nigra led to focus most parkinsonism research on basal ganglia (BG). However, recent findings point an active involvement cerebellum this syndrome. Here, we have developed multiscale computational model rodent brain's BG-cerebellar network. Simulations showed direct effect dopamine depletion must be taken into account reproduce alterations neural activity parkinsonism, particularly increased beta oscillations widely reported PD patients. Moreover, indirectly impacted spike-time-dependent plasticity at parallel fiber-Purkinje cell synapses, degrading associative learning observed parkinsonism. Overall, these results suggest relevant symptoms.

Language: Английский

Citations

4
Biochemical properties and biological potential of Syzygium heyneanum with antiparkinson’s activity in paraquat induced rodent model DOI
Malik Saadullah, Hafsa Tariq, Zunera Chauhdary

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(3), P. e0298986 - e0298986

Published: March 29, 2024

Syzygium heyneanum is a valuable source of flavonoids and phenols, known for their antioxidant neuroprotective properties. This research aimed to explore the potential ethanol extract (SHE) in countering Parkinson’s disease. The presence phenols results SHE displaying an IC 50 value 42.13 when assessed DPPH scavenging assay. Rats’ vital organs (lungs, heart, spleen, liver, kidney) histopathology reveals little or almost no harmful effect. study hypothesized that possesses antioxidants could mitigate symptoms by influencing α-synuclein, acetylcholinesterase (AChE), TNF-α, IL-1β. Both silico vivo investigations were conducted. rat model was established using paraquat (1 mg/kg, i.p.), with rats divided into control, disease standard, SHE-treated groups (150, 300, 600 mg/kg) 21 days. According ELISA statistics, treated group had lowers levels IL-6 TNF-α than control group, which sign neuroprotection. Behavioral biochemical assessments performed, alongside mRNA expression analyses RT-PCR assess SHE’s impact on AChE, interleukins brain homogenates. observations demonstrated dose-dependent improvements (600 > 300 150 mg/kg). Antioxidant enzyme (catalase, superoxide dismutase, glutathione) significantly restored, particularly at high dose, notable reduction malondialdehyde. dose notably lowered levels. qRT-PCR indicated reduced IL-1β, AChE compared controls, suggesting In conclusion, this highlights alleviate through its modulatory effects relevant biomarkers.

Language: Английский

Citations

3
Motor Features of Parkinson’s Disease DOI
Arjun Tarakad

Neurologic Clinics, Journal Year: 2025, Volume and Issue: 43(2), P. 279 - 289

Published: Jan. 22, 2025

Language: Английский

Citations

0
Resting‐State Functional MRI Regional Homogeneity Correlates With Motor Scores in Parkinson's Disease DOI
Wei Dai, Zhe Li, Hao Lin

et al.

Journal of Neuroimaging, Journal Year: 2025, Volume and Issue: 35(1)

Published: Jan. 1, 2025

This study investigated the neural mechanisms underlying Parkinson's disease (PD) subtypes-tremor dominant (TD) and postural instability gait difficulty (PIGD)-by analyzing regional homogeneity (ReHo) values from resting-state functional MRI. Fifty-nine PD patients (29 TD patients, 30 PIGD patients) healthy controls (HCs) were enrolled. ReHo analyzed via analysis of variance a two-sample t-test, with age sex as covariates. Correlations between clinical motor symptoms also examined. Distinct patterns observed in subtypes HCs. presented decreased cerebellar-thalamic-cortical circuit, whereas lower striatum supplementary area (SMA). had higher bilateral dorsolateral superior frontal gyrus SMA but medial orbital part other regions on left than patients. Specific brain correlated tremor scores, rigidity scores. Different HCs showed distinct patterns. correlation traits suggests its value biomarker for subtype-specific diagnostic strategies.

Language: Английский

Citations

0
A Machine Learning Approach for Early Parkinson's Disease Diagnosis Based on Brain Texture Features from T1-Weighted Imaging DOI Creative Commons
Yuhua Xu, Feifan Zhou, Qianqian Gao

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Abstract This study presents an early diagnostic method for Parkinson’s disease using T1-weighted imaging texture features combined with machine learning models. data from the PPMI database were preprocessed to extract various brain regions,including thalamus, hippocampus, caudate nucleus, amygdala, globus pallidus and putamen. The Random Forest (RF) model demonstrated excellent performance in distinguishing patients healthy controls, achieving AUC of 0.90, accuracy 88.9%, precision 92.3%, sensitivity specificity 80.0%, F1 score 92.3%. A simplified RF also exhibited strong a prediction 77.8%. effectively leverages assist diagnosis disease.

Language: Английский

Citations

0