Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(17)
Published: Jan. 29, 2023
Abstract
Reactive
oxygen
species
(ROS)‐induced
mitophagy
is
associated
with
a
variety
of
diseases.
Therefore,
visualizing
and
modulating
the
process
ROS‐induced
essential
for
understanding
role
in
cellular
homeostasis,
physiological
processes,
pathogenesis.
Herein,
using
fluorescence
lifetime
imaging
microscopy
(FLIM),
first
time
complete
dynamic
PINK1/Parkin
pathway‐mediated
described.
Induced
by
photo‐controlled
release
ROS,
nitrogen‐doped
multi‐functional
carbon
nanozymes
(ENZ‐NCDs)
used
as
probe
to
visualize
quantitatively
study
mitophagy.
The
successful
preparation
ENZ‐NCDs
provides
potentially
powerful
tool
new
strategy
real‐time
monitoring
future
quantification
mitochondrial
damage
caused
ROS
mitophagy‐related
Journal of Personalized Medicine,
Journal Year:
2021,
Volume and Issue:
11(2), P. 70 - 70
Published: Jan. 25, 2021
The
wide
spectrum
of
unique
needs
and
strengths
Autism
Spectrum
Disorders
(ASD)
is
a
challenge
for
the
worldwide
healthcare
system.
With
plethora
information
from
research,
common
thread
required
to
conceptualize
an
exhaustive
pathogenetic
paradigm.
epidemiological
clinical
findings
in
ASD
cannot
be
explained
by
traditional
linear
genetic
model,
hence
need
move
towards
more
fluid
conception,
integrating
genetics,
environment,
epigenetics
as
whole.
embryo-fetal
period
first
two
years
life
(the
so-called
‘First
1000
Days’)
are
crucial
time
window
neurodevelopment.
In
particular,
interplay
vicious
loop
between
immune
activation,
gut
dysbiosis,
mitochondrial
impairment/oxidative
stress
significantly
affects
neurodevelopment
during
pregnancy
undermines
health
people
throughout
life.
Consequently,
most
effective
intervention
expected
primary
prevention
aimed
at
early
control
main
effector
molecular
pathways.
We
will
reason
here
on
comprehensive
paradigm
ASD,
viewed
not
just
theoretical
issue,
but
tool
provide
suggestions
preventive
strategies
personalized,
dynamic
(from
womb
adulthood),
systemic,
interdisciplinary
approach.
Frontiers in Cardiovascular Medicine,
Journal Year:
2022,
Volume and Issue:
8
Published: Feb. 7, 2022
Heart
failure
(HF)
is
a
major
global
healthcare
problem
accounting
for
substantial
deterioration
of
prognosis.
As
complex
clinical
syndrome,
HF
often
coexists
with
multi-comorbidities
which
cognitive
impairment
(CI)
particularly
important.
CI
increasing
in
prevalence
among
patients
and
present
around
40%,
even
up
to
60%,
elderly
HF.
potent
independent
prognostic
factor,
significantly
increases
the
hospitalization
mortality
decreases
quality
life
There
has
been
growing
awareness
bidirectional
interaction
between
as
it
shares
number
common
pathophysiological
pathways
including
reduced
cerebral
blood
flow,
inflammation,
neurohumoral
activations.
Research
that
focus
on
precise
mechanism
still
ever
insufficient.
tremendous
adverse
consequences
HF,
effective
early
diagnosis
interventions
these
may
halt
disease
progression
improve
The
current
guidelines
have
begun
emphasize
importance
CI.
However,
nearly
half
underdiagnosed,
few
recommendations
are
available
guide
clinicians
about
how
approach
This
review
aims
synthesize
knowledge
link
dysfunction,
issues
pertaining
screening,
management
emerging
therapies
prevention.
Based
data
from
studies,
critical
gaps
identified,
future
research
directions
field
forward
proposed.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(17)
Published: Jan. 29, 2023
Abstract
Reactive
oxygen
species
(ROS)‐induced
mitophagy
is
associated
with
a
variety
of
diseases.
Therefore,
visualizing
and
modulating
the
process
ROS‐induced
essential
for
understanding
role
in
cellular
homeostasis,
physiological
processes,
pathogenesis.
Herein,
using
fluorescence
lifetime
imaging
microscopy
(FLIM),
first
time
complete
dynamic
PINK1/Parkin
pathway‐mediated
described.
Induced
by
photo‐controlled
release
ROS,
nitrogen‐doped
multi‐functional
carbon
nanozymes
(ENZ‐NCDs)
used
as
probe
to
visualize
quantitatively
study
mitophagy.
The
successful
preparation
ENZ‐NCDs
provides
potentially
powerful
tool
new
strategy
real‐time
monitoring
future
quantification
mitochondrial
damage
caused
ROS
mitophagy‐related
