Reactive astrocyte nomenclature, definitions, and future directions

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(3), P. 312 - 325

Published: Feb. 15, 2021

Language: Английский

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Reversing a model of Parkinson’s disease with in situ converted nigral neurons

Nature, Journal Year: 2020, Volume and Issue: 582(7813), P. 550 - 556

Published: June 24, 2020

Language: Английский

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Molecular basis of astrocyte diversity and morphology across the CNS in health and disease

Science, Journal Year: 2022, Volume and Issue: 378(6619)

Published: Nov. 3, 2022

Astrocytes, a type of glia, are abundant and morphologically complex cells. Here, we report astrocyte molecular profiles, diversity, morphology across the mouse central nervous system (CNS). We identified shared region-specific astrocytic genes functions explored cellular origins their regional diversity. gene networks correlated with morphology, several which unexpectedly contained Alzheimer’s disease (AD) risk genes. CRISPR/Cas9–mediated reduction candidate reduced morphological complexity resulted in cognitive deficits. The same were down-regulated human AD, an AD model that displayed other brain disorders. thus provide comprehensive data on diversity mechanisms CNS basis health disease.

Language: Английский

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Astrocyte-neuron metabolic cooperation shapes brain activity

Cell Metabolism, Journal Year: 2021, Volume and Issue: 33(8), P. 1546 - 1564

Published: Aug. 1, 2021

Language: Английский

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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 16, 2024

Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management

Language: Английский

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Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration

Nature Reviews Neurology, Journal Year: 2023, Volume and Issue: 19(7), P. 395 - 409

Published: June 12, 2023

Language: Английский

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Astrocytes contribute to remote memory formation by modulating hippocampal–cortical communication during learning

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(10), P. 1229 - 1239

Published: Aug. 3, 2020

Language: Английский

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Behaviorally consequential astrocytic regulation of neural circuits

Neuron, Journal Year: 2020, Volume and Issue: 109(4), P. 576 - 596

Published: Dec. 31, 2020

Language: Английский

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Making sense of astrocytic calcium signals — from acquisition to interpretation

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(10), P. 551 - 564

Published: Sept. 1, 2020

Language: Английский

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Chemico-genetic discovery of astrocytic control of inhibition in vivo

Nature, Journal Year: 2020, Volume and Issue: 588(7837), P. 296 - 302

Published: Nov. 11, 2020

Language: Английский

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