Neurochemistry International, Journal Year: 2023, Volume and Issue: 169, P. 105572 - 105572
Published: July 7, 2023
Language: Английский
Nature Reviews Materials, Journal Year: 2023, Volume and Issue: 8(9), P. 604 - 622
Published: Aug. 24, 2023
Language: Английский
Citations
133
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Sept. 1, 2023
Abstract Low-intensity transcranial ultrasound stimulation (TUS) is an emerging non-invasive technique for focally modulating human brain function. The mechanisms and neurochemical substrates underlying TUS neuromodulation in humans how these relate to excitation inhibition are still poorly understood. In 24 healthy controls, we separately stimulated two deep cortical regions investigated the effects of theta-burst TUS, a protocol shown increase corticospinal excitability, on inhibitory neurotransmitter gamma-aminobutyric acid (GABA) functional connectivity. We show that selectively reduces GABA levels posterior cingulate, but not dorsal anterior cingulate cortex. Functional connectivity increased following both regions. Our findings suggest changes overall excitability by reducing GABAergic TUS-mediated neuroplasticity last at least 50 mins after stimulation. difference could state- or location-dependency effect—both increasingly recognized influence brain’s response neuromodulation.
Language: Английский
Citations
69
Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 49(1), P. 128 - 137
Published: May 22, 2023
Abstract Accelerated TMS is an emerging application of Transcranial Magnetic Stimulation (TMS) aimed to reduce treatment length and improve response time. Extant literature generally shows similar efficacy safety profiles compared the FDA-cleared protocols for treat major depressive disorder (MDD), yet accelerated research remains at a very early stage in development. The few applied have not been standardized vary significantly across set core elements. In this review, we consider nine elements that include parameters (i.e., frequency inter-stimulation interval), cumulative exposure number days, sessions per day, pulses session), individualized target dose), brain state context concurrent treatments). Precisely which these critical what are most optimal MDD unclear. Other important considerations durability effect, as doses increase over time, possibility advantage functional neuronavigation, use biological readouts, accessibility patients need treatment. Overall, appears hold promise time achieve rapid reduction symptoms, but significant work be done. Rigorous clinical trials combining outcomes neuroscientific measures such electroencephalogram, magnetic resonance imaging e-field modeling needed define future MDD.
Language: Английский
Citations
48
Biological Psychiatry, Journal Year: 2023, Volume and Issue: 95(6), P. 536 - 544
Published: Sept. 21, 2023
Transcranial magnetic stimulation (TMS) is capable of noninvasively inducing lasting neuroplastic changes when applied repetitively across multiple treatment sessions. In recent years, repetitive TMS has developed into an established evidence-based for various neuropsychiatric disorders such as depression. Despite significant advancements in our understanding the mechanisms action TMS, there still much to learn about how these relate clinical effects observed patients. If one thing that we know sure, it are state dependent. this review, describe on brain networks depend factors, including cognitive state, oscillatory and history. These states play a crucial role determining at moment therefore directly linked what referred target engagement therapy. There no control over without considering different dependencies intervention. Clinical protocols largely ignoring fundamental principle, which may explain large variability often limited efficacy treatments. We propose after almost 30 years research dependency time change standard practice by taking advantage principle. Rather than dependency, can use improve effectiveness
Language: Английский
Citations
47
Cyborg and Bionic Systems, Journal Year: 2023, Volume and Issue: 4
Published: Jan. 1, 2023
Cross-frequency coupling (CFC) reflects (nonlinear) interactions between signals of different frequencies. Evidence from both patient and healthy participant studies suggests that CFC plays an essential role in neuronal computation, interregional interaction, disease pathophysiology. The present review discusses methodological advances challenges the computation with particular emphasis on potential solutions to spurious coupling, inferring intrinsic rhythms a targeted frequency band, causal interferences. We specifically focus literature exploring context cognition/memory tasks, sleep, neurological disorders, such as Alzheimer's disease, epilepsy, Parkinson's disease. Furthermore, we highlight implication for optimization invasive noninvasive neuromodulation rehabilitation. Mainly, could support advancing understanding neurophysiology cognition motor control, serve biomarker symptoms, leverage therapeutic interventions, e.g., closed-loop brain stimulation. Despite evident advantages investigative translational tool neuroscience, further improvements are required facilitate practical correct use cyborg bionic systems field.
Language: Английский
Citations
46
Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(9), P. 2678 - 2688
Published: March 26, 2024
Transcranial magnetic stimulation (TMS) applied to a left dorsolateral prefrontal cortex (DLPFC) area with specific connectivity profile the subgenual anterior cingulate (sgACC) has emerged as highly effective non-invasive treatment option for depression. However, antidepressant outcomes demonstrate significant variability among therapy plans and individuals. One overlooked contributing factor is individual brain state at time of treatment. In this study we used interleaved TMS-fMRI investigate influence on acute TMS effects, both locally remotely. was performed during rest different phases cognitive task processing. Twenty healthy participants were included in study. first session, imaging data targeting acquired, allowing identification individualized targets DLPFC based highest anti-correlation sgACC. The second session involved chronometric measurements, 10 Hz triplets administered distinct timings an N-back task. Consistent prior findings, revealed BOLD activation changes targeted network. precise timing relative states demonstrated response clinically relevant regions, including Employing standardized approach using more consistent modulation sgACC group level compared rest. conclusion, our findings strongly suggest that local remote effects are influenced by stimulation. This establishes basis considering designing protocols, possibly improving outcomes.
Language: Английский
Citations
18
Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Language: Английский
Citations
2
ACS Nano, Journal Year: 2023, Volume and Issue: 17(18), P. 17634 - 17667
Published: Sept. 7, 2023
Soft bioelectronics play an increasingly crucial role in high-precision therapeutics due to their softness, biocompatibility, clinical accuracy, long-term stability, and patient-friendliness. In this review, we provide a comprehensive overview of the latest representative therapeutic applications advanced soft bioelectronics, ranging from wearable for skin wounds, diabetes, ophthalmic diseases, muscle disorders, other diseases implantable against complex such as cardiac arrhythmias, cancer, neurological others. We also highlight key challenges opportunities future translation commercialization toward personalized medicine.
Language: Английский
Citations
36
Biological Psychiatry, Journal Year: 2023, Volume and Issue: 95(6), P. 545 - 552
Published: Sept. 22, 2023
In the same way that beauty lies in eye of beholder, what a stimulus does to brain is determined not simply by nature stimulus, but receiving at instant time. Therapeutic stimulation, over past decades, typically applied open-loop fixed protocols and has largely ignored this principle. Only recent neuro-technological advancements enabled us predict (i.e., electrophysiological state next time) with sufficient temporal precision range milliseconds, using feedforward algorithms EEG time series data. This allows stimulation exclusively whenever targeted area prespecified excitability or connectivity state. Preclinical studies showed repetitive during particular (e.g., high-excitability state), other states, results lasting modification long-term potentiation) stimulated circuits. Here we survey evidence also possible systems level human cortex, EEG-informed transcranial magnetic (EEG-TMS). We discuss critically opportunities difficulties develop state-dependent for more effective pathological networks major depressive disorder) than achievable conventional protocols. The real-time EEG-TMS technology will allow closing loop recording effects stimulation. information may serve protocol adaptation maximize treatment response. way, states control introducing paradigm-shift from closed-loop
Language: Английский
Citations
30
International Journal of Clinical and Health Psychology, Journal Year: 2023, Volume and Issue: 23(3), P. 100378 - 100378
Published: Feb. 16, 2023
Variability in findings related to non-invasive brain stimulation (NIBS) have increasingly been described as a result of differences neurophysiological state. Additionally, there is some evidence suggesting that individual psychological states may correlate with the magnitude and directionality effects NIBS on neural behavioural level. In this narrative review, it proposed assessment baseline affective can quantify non-reductive properties which are not readily accessible neuroscientific methods. Particularly, affective-related theorized physiological, phenomenological NIBS. While further systematic research needed, suggested provide complementary cost-effective source information for understanding variability outcomes. Implementing measures state potentially contribute increasing sensitivity specificity results experimental clinical studies.
Language: Английский
Citations
27