Solving the Global Opioid Crisis: Incorporating Genetic Addiction Risk Assessment with Personalized Dopaminergic Homeostatic Therapy and Awareness Integration Therapy DOI
Foojan Zeine, Nicole Jafari, David Baron

et al.

Published: June 20, 2024

The opioid crisis in the last few decades has mounted to a global level, impacting all areas of socioeconomic, demographic, geographic, and cultural boundaries. Traditional treatments have not been deemed show degree efficacy necessary address crisis. authors this review paper set forth an unprecedented in-depth look into multi-factorial determinants that contributed becoming multi-faceted. For narrative review/opinion article, we searched PsychINFO, PubMed, Google Scholar, Web Science databases identify relevant articles on topics including "opioid crisis," mechanisms," "genetics epigenetics," "neuropharmacology," "clinical aspects treatment prevention." Since was systematic selected could represent unitential bias. Despite some success achieved through Opioid Substitution Therapy (OST) harm reduction, annual mortality toll US alone surpasses 106,699 individuals, figure expected climb 165,000 by 2025. Data from Substance Abuse Mental Health Services Administration's (SAMHSA) National Survey Drug (NSDUH) reveals approximately 21.4% individuals engaged illicit drug use 2020, with 40.3 million aged 12 or older experiencing Use Disorder (SUD). Provisional figures Centers for Disease Control Prevention (CDC) indicate troubling 15% increase overdose deaths 2021, rising 93,655 2020 107,622, opioids accounting roughly 80,816 these deaths. We advocate reevaluating "standard care" shifting towards inducing dopamine homeostasis manipulating key neurotransmitter systems within brain's reward cascade. propose paradigm shift novel begins incorporating Genetic Addiction Risk Severity (GARS) testing assess pre-addiction risk vulnerability opioid-induced addiction; emphasis should be placed safe non-addictive alternatives like KB220, comprehensive approaches psychological, spiritual, societal addiction Awareness Integration (AIT).

Language: Английский

Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations DOI Creative Commons
Sarah E. Paul, David A. A. Baranger, Emma C. Johnson

et al.

Psychological Medicine, Journal Year: 2024, Volume and Issue: 54(10), P. 2644 - 2657

Published: May 9, 2024

Although the link between alcohol involvement and behavioral phenotypes (e.g. impulsivity, negative affect, executive function [EF]) is well-established, directionality of these associations, specificity to stages involvement, extent shared genetic liability remain unclear. We estimate longitudinal associations transitions among milestones, phenotypes, indices risk.

Language: Английский

Citations

0
‘Black dealers kill people and come from the projects; Whites dealers kill people and come from nice families’: contextualized racialized perceptions of related criminal behaviors within an attribution theory framework DOI Creative Commons
Eileen M. Ahlin

Journal of Crime and Justice, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 20

Published: June 4, 2024

Some believe certain racial groups are associated with specific behaviors, like homicide, drug dealing, and use. It is unclear if these perceptions connected or culpability as offender victim for behaviors also racialized. The present study examines of people's involvement in related criminal behaviors. Using semi-structured interviews, data were gathered from men women (n=32) living 15 contiguous neighborhoods a mid-sized city the northeastern US. All area experienced effects opioid epidemic repercussions subsidized public housing policy changes, some had high levels violent crimes. Interview analyzed using thematic content analysis applying iterative, open coding techniques to identify themes recurrent concepts across participants. Findings show that respondents viewed Black persons engaged homicides dealers offenders white use victims. Crimes attributed people contextualized problem among gang members receiving housing. Applying threat hypothesis, findings implications research on racialized victims discussed within an attribution theory framework.

Language: Английский

Citations

0
chrna3modulates biphasic response to alcohol DOI Creative Commons
J. Dale Raine, Caroline Kibat, Tirtha Das Banerjee

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 22, 2024

Abstract Alcohol use disorders (AUDs) are complex phenomena governed by genetics, neurophysiology, environment, and societal structures. New methods to understand the underlying neurogenetics valuable for designing personalised interventional strategies. Here, we used a novel, two-choice self-administration zebrafish assay (SAZA) isolate function of nicotinic acetylcholine receptor (nAChR) subunit alpha3 ( chrna3 ) in alcohol response. Juvenile exhibited biphasic response when self-administering that transitioned from attraction aversion within minutes, suggesting they can regulate exposure alcohol. This inverted U-shaped mirrored effect has on shoaling behaviour. Exposure low concentration reduced anxiety-like behaviours, while sedative effects became prominent at higher concentrations resulting locomotion uncoordinated swimming. In contrast, these responses blunted mutants. They exhibit prolonged self-administration, increased gregariousness. Transcriptomic analyses suggest glutamatergic GABAergic neurotransmission alongside cholinergic signalling is impacted mutant brains. Our results thus dysfunction systemic change with an increase tolerance being one effect. These findings also highlight non-rodent alternatives development AUD. Highlights SAZA reveals hormesis zebrafish. crucial mount aversive Anxiolytic

Language: Английский

Citations

0
Examining the causal genetic effects of substance use on aging DOI Creative Commons
Jared V. Balbona,

Paul W. Jeffries,

Aaron J. Gorelik

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Substance use shortens lifespan, impedes health, and accelerates the biological aging process. We found widespread genetic correlations between alcohol, tobacco, cannabis, opioid disorders with indices of across lifespan. There was evidence tobacco alcohol causally impacting physical, cognitive, aging, effects being more dependent on quantity consumption; reverse causality scant.

Language: Английский

Citations

0
Solving the Global Opioid Crisis: Incorporating Genetic Addiction Risk Assessment with Personalized Dopaminergic Homeostatic Therapy and Awareness Integration Therapy DOI
Foojan Zeine, Nicole Jafari, David Baron

et al.

Published: June 20, 2024

The opioid crisis in the last few decades has mounted to a global level, impacting all areas of socioeconomic, demographic, geographic, and cultural boundaries. Traditional treatments have not been deemed show degree efficacy necessary address crisis. authors this review paper set forth an unprecedented in-depth look into multi-factorial determinants that contributed becoming multi-faceted. For narrative review/opinion article, we searched PsychINFO, PubMed, Google Scholar, Web Science databases identify relevant articles on topics including "opioid crisis," mechanisms," "genetics epigenetics," "neuropharmacology," "clinical aspects treatment prevention." Since was systematic selected could represent unitential bias. Despite some success achieved through Opioid Substitution Therapy (OST) harm reduction, annual mortality toll US alone surpasses 106,699 individuals, figure expected climb 165,000 by 2025. Data from Substance Abuse Mental Health Services Administration's (SAMHSA) National Survey Drug (NSDUH) reveals approximately 21.4% individuals engaged illicit drug use 2020, with 40.3 million aged 12 or older experiencing Use Disorder (SUD). Provisional figures Centers for Disease Control Prevention (CDC) indicate troubling 15% increase overdose deaths 2021, rising 93,655 2020 107,622, opioids accounting roughly 80,816 these deaths. We advocate reevaluating "standard care" shifting towards inducing dopamine homeostasis manipulating key neurotransmitter systems within brain's reward cascade. propose paradigm shift novel begins incorporating Genetic Addiction Risk Severity (GARS) testing assess pre-addiction risk vulnerability opioid-induced addiction; emphasis should be placed safe non-addictive alternatives like KB220, comprehensive approaches psychological, spiritual, societal addiction Awareness Integration (AIT).

Language: Английский

Citations

0