Journal of Computational Science, Journal Year: 2025, Volume and Issue: unknown, P. 102525 - 102525
Published: Jan. 1, 2025
Language: Английский
Trends in Cognitive Sciences, Journal Year: 2024, Volume and Issue: 28(4), P. 352 - 368
Published: Jan. 9, 2024
To explain how the brain orchestrates information-processing for cognition, we must understand information itself. Importantly, is not a monolithic entity. Information decomposition techniques provide way to split into its constituent elements: unique, redundant, and synergistic information. We review disentangling redundant interactions redefining our understanding of integrative function neural organisation. navigates trade-offs between redundancy synergy, converging evidence integrating structural, molecular, functional underpinnings synergy redundancy; their roles in cognition computation; they might arise over evolution development. Overall, provides guiding principle informational architecture cognition.
Language: Английский
Citations
63
Biomedicines, Journal Year: 2024, Volume and Issue: 12(2), P. 448 - 448
Published: Feb. 17, 2024
The orexin/hypocretin neuropeptide family has emerged as a focal point of neuroscientific research following the discovery that this plays crucial role in variety physiological and behavioral processes. These neuropeptides serve powerful neuromodulators, intricately shaping autonomic, endocrine, responses across species. Notably, they master regulators vigilance stress responses; however, their roles food intake, metabolism, thermoregulation appear complementary warrant further investigation. This narrative review provides journey through evolution our understanding orexin system, from its initial to promising progress made developing derivatives. It goes beyond conventional boundaries, striving synthesize multifaceted activities orexins. Special emphasis is placed on domains such response, fear, anxiety, learning, which authors have contributed literature with original publications. paper also overviews advancement pharmacology, already yielded some successes, particularly treatment sleep disorders.
Language: Английский
Citations
22
Cells, Journal Year: 2025, Volume and Issue: 14(1), P. 54 - 54
Published: Jan. 5, 2025
Neuroinflammation is a complex and multifaceted process that involves dynamic interactions among various cellular molecular components. This sophisticated interplay supports both environmental adaptability system resilience in the central nervous (CNS) but may be disrupted during neuroinflammation. In this article, we first characterize key players neuroimmune interactions, including microglia, astrocytes, neurons, immune cells, essential signaling molecules such as cytokines, neurotransmitters, extracellular matrix (ECM) components, neurotrophic factors. Under homeostatic conditions, these elements promote cooperation stability, whereas neuroinflammatory states, they drive adaptive responses become pathological if dysregulated. We examine how mediated through actors pathways, create networks regulate CNS functionality respond to injury or inflammation. To further elucidate dynamics, provide insights using multilayer network (MLN) approach, highlighting interconnected nature of under inflammatory conditions. perspective aims enhance our understanding communication mechanisms underlying shifts from homeostasis Applying an MLN approach offers more integrative view adaptability, helping clarify processes identify novel intervention points within layered landscape responses.
Language: Английский
Citations
5
Physics of Life Reviews, Journal Year: 2025, Volume and Issue: 53, P. 24 - 75
Published: Feb. 27, 2025
Language: Английский
Citations
3
Biological Psychiatry, Journal Year: 2023, Volume and Issue: 95(6), P. 510 - 522
Published: Nov. 29, 2023
The development of neuroimaging methodologies to map brain connectivity has transformed our understanding psychiatric disorders, the distributed effects stimulation, and how transcranial magnetic stimulation can be best employed target ameliorate symptoms. In parallel, research revealed that higher-order regions such as prefrontal cortex, which represent most common therapeutic targets for show some highest levels interindividual variation in connectivity. These findings provide rationale personalized site selection based on person-specific network architecture. Recent advances have made it possible determine reproducible with millimeter precision clinically tractable acquisition times. enable potential advantages spatially targeting evaluated translated basic clinical applications. this review, we outline motivation personalization, preliminary support (mostly depression), convergent evidence from other modalities, generalizability beyond depression cortex. We end by detailing methodological recommendations, controversies, notable alternatives. Overall, while area appears highly promising, value remains unclear, dedicated large prospective randomized trials using validated methodology are critical.
Language: Английский
Citations
40
Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 47(2), P. 106 - 119
Published: Dec. 22, 2023
Language: Английский
Citations
31
Chaos Solitons & Fractals, Journal Year: 2024, Volume and Issue: 180, P. 114549 - 114549
Published: Feb. 2, 2024
Language: Английский
Citations
14
Nature Protocols, Journal Year: 2024, Volume and Issue: unknown
Published: July 29, 2024
Language: Английский
Citations
11
European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(1)
Published: Jan. 1, 2025
Abstract Within the reductionist framework, researchers in special sciences formulate key terms and concepts try to explain them with lower‐level science concepts. For example, behavioural vision scientists describe contrast perception a psychometric function, which perceived brightness increases logarithmically physical of light patch (the Weber‐Fechner law). Visual neuroscientists output neural circuits neurometric functions. Intuitively, from two adjacent scientific domains should map onto each other; for instance, functions may other. Identifying such mappings has been very goal neuroscience nearly centuries. Yet mapping behaviour brain measures turned out be difficult. Here, we provide various arguments as why conspicuous lack robust brain–behaviour is rather rule than an exception. First, overview methodological conceptual issues that stand way successful mapping. Second, extending previous theoretical work (Herzog, Doerig Sachse, 2023), show limited by complexity barriers. In this case, reduction impossible.
Language: Английский
Citations
1
European Journal of Nuclear Medicine and Molecular Imaging, Journal Year: 2025, Volume and Issue: unknown
Published: March 7, 2025
Language: Английский
Citations
1