Peri-somatic modulation of diffracted light and its variation with consciousness DOI Open Access
Santosh A. Helekar

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract Existing noninvasive neurophysiological recording methods can acquire neuronal correlates of consciousness, but they do not differentiate between conscious and unconscious states mechanistically. Here we describe a method that detects new physical effect apparent neural origin in the peri-somatic space might allow such differentiation. This is slow decrease intensity diffracted low power laser light emitted within photoelectronic device placed close to body an awake subject. It markedly attenuated by general anesthesia mice unconsciousness patients. Its direction reversed when exposed live invertebrates or decapitated head euthanized mouse. These findings reveal previously unrecognized biophysical phenomenon appears be related consciousness.

Language: Английский

Information decomposition and the informational architecture of the brain DOI Creative Commons
Andrea I. Luppi, Fernando Rosas, Pedro A. M. Mediano

et al.

Trends in Cognitive Sciences, Journal Year: 2024, Volume and Issue: 28(4), P. 352 - 368

Published: Jan. 9, 2024

To explain how the brain orchestrates information-processing for cognition, we must understand information itself. Importantly, is not a monolithic entity. Information decomposition techniques provide way to split into its constituent elements: unique, redundant, and synergistic information. We review disentangling redundant interactions redefining our understanding of integrative function neural organisation. navigates trade-offs between redundancy synergy, converging evidence integrating structural, molecular, functional underpinnings synergy redundancy; their roles in cognition computation; they might arise over evolution development. Overall, provides guiding principle informational architecture cognition.

Language: Английский

Citations

62
The Orexin/Hypocretin System, the Peptidergic Regulator of Vigilance, Orchestrates Adaptation to Stress DOI Creative Commons
Miklós Jászberényi,

Balázs Thurzó,

Zsolt Bagosi

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(2), P. 448 - 448

Published: Feb. 17, 2024

The orexin/hypocretin neuropeptide family has emerged as a focal point of neuroscientific research following the discovery that this plays crucial role in variety physiological and behavioral processes. These neuropeptides serve powerful neuromodulators, intricately shaping autonomic, endocrine, responses across species. Notably, they master regulators vigilance stress responses; however, their roles food intake, metabolism, thermoregulation appear complementary warrant further investigation. This narrative review provides journey through evolution our understanding orexin system, from its initial to promising progress made developing derivatives. It goes beyond conventional boundaries, striving synthesize multifaceted activities orexins. Special emphasis is placed on domains such response, fear, anxiety, learning, which authors have contributed literature with original publications. paper also overviews advancement pharmacology, already yielded some successes, particularly treatment sleep disorders.

Language: Английский

Citations

22
From Homeostasis to Neuroinflammation: Insights into Cellular and Molecular Interactions and Network Dynamics DOI Creative Commons

Ludmila Müller,

Svetlana Di Benedetto,

Viktor Müller

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(1), P. 54 - 54

Published: Jan. 5, 2025

Neuroinflammation is a complex and multifaceted process that involves dynamic interactions among various cellular molecular components. This sophisticated interplay supports both environmental adaptability system resilience in the central nervous (CNS) but may be disrupted during neuroinflammation. In this article, we first characterize key players neuroimmune interactions, including microglia, astrocytes, neurons, immune cells, essential signaling molecules such as cytokines, neurotransmitters, extracellular matrix (ECM) components, neurotrophic factors. Under homeostatic conditions, these elements promote cooperation stability, whereas neuroinflammatory states, they drive adaptive responses become pathological if dysregulated. We examine how mediated through actors pathways, create networks regulate CNS functionality respond to injury or inflammation. To further elucidate dynamics, provide insights using multilayer network (MLN) approach, highlighting interconnected nature of under inflammatory conditions. perspective aims enhance our understanding communication mechanisms underlying shifts from homeostasis Applying an MLN approach offers more integrative view adaptability, helping clarify processes identify novel intervention points within layered landscape responses.

Language: Английский

Citations

3
Nonlocal Models in Biology and Life Sciences: Sources, Developments, and Applications DOI Creative Commons
Swadesh Pal, Roderick Melnik

Physics of Life Reviews, Journal Year: 2025, Volume and Issue: 53, P. 24 - 75

Published: Feb. 27, 2025

Language: Английский

Citations

2
Personalized and Circuit-Based Transcranial Magnetic Stimulation: Evidence, Controversies, and Opportunities DOI Creative Commons
Robin Cash, Andrew Zalesky

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 95(6), P. 510 - 522

Published: Nov. 29, 2023

The development of neuroimaging methodologies to map brain connectivity has transformed our understanding psychiatric disorders, the distributed effects stimulation, and how transcranial magnetic stimulation can be best employed target ameliorate symptoms. In parallel, research revealed that higher-order regions such as prefrontal cortex, which represent most common therapeutic targets for show some highest levels interindividual variation in connectivity. These findings provide rationale personalized site selection based on person-specific network architecture. Recent advances have made it possible determine reproducible with millimeter precision clinically tractable acquisition times. enable potential advantages spatially targeting evaluated translated basic clinical applications. this review, we outline motivation personalization, preliminary support (mostly depression), convergent evidence from other modalities, generalizability beyond depression cortex. We end by detailing methodological recommendations, controversies, notable alternatives. Overall, while area appears highly promising, value remains unclear, dedicated large prospective randomized trials using validated methodology are critical.

Language: Английский

Citations

37
Toward individualized connectomes of brain morphology DOI Open Access
Jinhui Wang, Yong He

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 47(2), P. 106 - 119

Published: Dec. 22, 2023

Language: Английский

Citations

29
Chimera-like state in the bistable excitatory-inhibitory cortical neuronal network DOI
Xuening Li, Ying Xie,

Zhiqiu Ye

et al.

Chaos Solitons & Fractals, Journal Year: 2024, Volume and Issue: 180, P. 114549 - 114549

Published: Feb. 2, 2024

Language: Английский

Citations

14
A network control theory pipeline for studying the dynamics of the structural connectome DOI
Linden Parkes,

Jason Z. Kim,

Jennifer Stiso

et al.

Nature Protocols, Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Language: Английский

Citations

10
Computational complexity as a potential limitation on brain–behaviour mapping DOI Creative Commons
Ayberk Ozkirli, Michael H. Herzog, Maya A. Jastrzębowska

et al.

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(1)

Published: Jan. 1, 2025

Abstract Within the reductionist framework, researchers in special sciences formulate key terms and concepts try to explain them with lower‐level science concepts. For example, behavioural vision scientists describe contrast perception a psychometric function, which perceived brightness increases logarithmically physical of light patch (the Weber‐Fechner law). Visual neuroscientists output neural circuits neurometric functions. Intuitively, from two adjacent scientific domains should map onto each other; for instance, functions may other. Identifying such mappings has been very goal neuroscience nearly centuries. Yet mapping behaviour brain measures turned out be difficult. Here, we provide various arguments as why conspicuous lack robust brain–behaviour is rather rule than an exception. First, overview methodological conceptual issues that stand way successful mapping. Second, extending previous theoretical work (Herzog, Doerig Sachse, 2023), show limited by complexity barriers. In this case, reduction impossible.

Language: Английский

Citations

1
A multi-modal, asymmetric, weighted, and signed description of anatomical connectivity DOI Creative Commons
Jacob Tanner, Joshua Faskowitz, Andreia Sofia Teixeira

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 12, 2024

Abstract The macroscale connectome is the network of physical, white-matter tracts between brain areas. connections are generally weighted and their values interpreted as measures communication efficacy. In most applications, weights either assigned based on imaging features–e.g. diffusion parameters–or inferred using statistical models. reality, ground-truth unknown, motivating exploration alternative edge weighting schemes. Here, we explore a multi-modal, regression-based model that endows reconstructed fiber with directed signed weights. We find fits observed data well, outperforming suite null estimated subject-specific highly reliable, even when fit relatively few training samples, networks maintain number desirable features. summary, offer simple framework for data, demonstrating both its ease implementation while benchmarking utility typical analyses, including graph theoretic modeling brain-behavior associations.

Language: Английский

Citations

7